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3 similar compounds to monomer 50303975

Compile data set for download or QSAR
Wt: 538.6
BDBM50043271
Wt: 536.6
BDBM50292632
Wt: 360.4
BDBM50303978

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50043271,50292632,50303978   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AGTR1


(RAT)
BDBM50303978
PNG
(1-(4-(2-(1H-tetrazol-5-yl)ethyl)benzyl)-4-methyl-2...)
Show SMILES CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1
Show InChI InChI=1S/C21H24N6/c1-3-5-20-22-21-15(2)6-4-7-18(21)27(20)14-17-10-8-16(9-11-17)12-13-19-23-25-26-24-19/h4,6-11H,3,5,12-14H2,1-2H3,(H,23,24,25,26)
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Article
PubMed
2.84E+3n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane


J Med Chem 53: 1076-85 (2010)


Article DOI: 10.1021/jm901272d
BindingDB Entry DOI: 10.7270/Q22V2H2Q
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043271
PNG
(1,7'-Dimethyl-2'-propyl-3'-[2'-(1H-tetrazol-5-yl)-...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1nc2ccccc2n1C
Show InChI InChI=1S/C33H30N8/c1-4-9-30-35-31-21(2)18-24(33-34-27-12-7-8-13-28(27)40(33)3)19-29(31)41(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)32-36-38-39-37-32/h5-8,10-19H,4,9,20H2,1-3H3,(H,36,37,38,39)
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Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


J Med Chem 36: 4040-51 (1994)


Article DOI: 10.1021/jm00077a007
BindingDB Entry DOI: 10.7270/Q2V98746
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50292632
PNG
(4'-{[2-n-propyl-4-methyl-6-(1-methylbenzoimidazol-...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1ncc[nH]1)-c1nc2ccccc2n1C
Show InChI InChI=1S/C35H32N6/c1-4-9-32-39-33-23(2)20-26(35-38-29-12-7-8-13-30(29)40(35)3)21-31(33)41(32)22-24-14-16-25(17-15-24)27-10-5-6-11-28(27)34-36-18-19-37-34/h5-8,10-21H,4,9,22H2,1-3H3,(H,36,37)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex


Bioorg Med Chem 16: 10301-10 (2008)


Article DOI: 10.1016/j.bmc.2008.10.040
BindingDB Entry DOI: 10.7270/Q2HT2P5T
More data for this
Ligand-Target Pair