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20 similar compounds to monomer 50046012

Compile data set for download or QSAR
Wt: 401.5
BDBM50045957
Wt: 439.5
BDBM50045961
Wt: 453.5
BDBM50045962
Wt: 431.5
BDBM50045967
Wt: 543.7
BDBM50045969
Wt: 467.5
BDBM50045970
Wt: 405.4
BDBM50045977
Wt: 421.4
BDBM50045979
Purchase
Wt: 377.4
BDBM50045982
Wt: 454.5
BDBM50045985
Wt: 417.5
BDBM50045987
Wt: 468.5
BDBM50045990
Wt: 424.5
BDBM50045991
Wt: 511.6
BDBM50045992
Wt: 460.5
BDBM50045994
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50045957,50045961,50045962,50045967,50045969,50045970,50045977,50045979,50045982,50045985,50045987,50045990,50045991,50045992,50045994   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045979
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES COC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C23H27N5O3/c1-17-19(9-6-10-25-17)21(16-24)27-11-13-28(14-12-27)22(29)15-20(26-23(30)31-2)18-7-4-3-5-8-18/h3-10,20-21H,11-15H2,1-2H3,(H,26,30)
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n/an/a 41n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045982
PNG
(CHEMBL103596 | [4-(3-Methylamino-3-phenyl-propiony...)
Show SMILES CNC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-17-19(9-6-10-25-17)21(16-23)26-11-13-27(14-12-26)22(28)15-20(24-2)18-7-4-3-5-8-18/h3-10,20-21,24H,11-15H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045962
PNG
(CHEMBL100597 | {4-[3-(Benzhydryl-amino)-propionyl]...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CCNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c1-22-25(13-8-15-30-22)26(21-29)32-17-19-33(20-18-32)27(34)14-16-31-28(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-13,15,26,28,31H,14,16-20H2,1H3
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n/an/a 120n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045991
PNG
(CHEMBL100642 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O/c1-21-24(13-8-14-29-21)26(20-28)30-15-17-31(18-16-30)27(32)19-25(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045994
PNG
(CHEMBL100971 | Pyrrolidine-1-carboxylic acid (3-{4...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C26H32N6O2/c1-20-22(10-7-11-28-20)24(19-27)30-14-16-31(17-15-30)25(33)18-23(21-8-3-2-4-9-21)29-26(34)32-12-5-6-13-32/h2-4,7-11,23-24H,5-6,12-18H2,1H3,(H,29,34)
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n/an/a 64n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045985
PNG
((2-Methyl-pyridin-3-yl)-(4-{3-phenyl-3-[(pyridin-3...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCc1cccnc1)c1ccccc1
Show InChI InChI=1S/C27H30N6O/c1-21-24(10-6-12-30-21)26(18-28)32-13-15-33(16-14-32)27(34)17-25(23-8-3-2-4-9-23)31-20-22-7-5-11-29-19-22/h2-12,19,25-26,31H,13-17,20H2,1H3
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n/an/a 75n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045969
PNG
(CHEMBL103761 | [4-(3-Dibenzylamino-3-phenyl-propio...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N(Cc1ccccc1)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H37N5O/c1-28-32(18-11-19-37-28)34(25-36)38-20-22-39(23-21-38)35(41)24-33(31-16-9-4-10-17-31)40(26-29-12-5-2-6-13-29)27-30-14-7-3-8-15-30/h2-19,33-34H,20-24,26-27H2,1H3
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n/an/a 41n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045961
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-phenylamino...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c1-21-24(13-8-14-29-21)26(20-28)31-15-17-32(18-16-31)27(33)19-25(22-9-4-2-5-10-22)30-23-11-6-3-7-12-23/h2-14,25-26,30H,15-19H2,1H3
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n/an/a 28n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045977
PNG
(CHEMBL102774 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES CC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C23H27N5O2/c1-17-20(9-6-10-25-17)22(16-24)27-11-13-28(14-12-27)23(30)15-21(26-18(2)29)19-7-4-3-5-8-19/h3-10,21-22H,11-15H2,1-2H3,(H,26,29)
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n/an/a 31n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045967
PNG
((2-Methyl-pyridin-3-yl)-{4-[3-(2-oxo-pyrrolidin-1-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCCC1=O)c1ccccc1
Show InChI InChI=1S/C25H29N5O2/c1-19-21(9-5-11-27-19)23(18-26)28-13-15-29(16-14-28)25(32)17-22(20-7-3-2-4-8-20)30-12-6-10-24(30)31/h2-5,7-9,11,22-23H,6,10,12-17H2,1H3
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n/an/a 30n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045990
PNG
(CHEMBL102070 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-20-23(10-6-12-30-20)25(18-28)32-13-15-33(16-14-32)26(34)17-24(21-7-3-2-4-8-21)31-27(35)22-9-5-11-29-19-22/h2-12,19,24-25H,13-17H2,1H3,(H,31,35)
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n/an/a 8.90n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045992
PNG
(Benzyl-(3-{4-[cyano-(2-methyl-pyridin-3-yl)-methyl...)
Show SMILES COC(=O)N(Cc1ccccc1)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C30H33N5O3/c1-23-26(14-9-15-32-23)28(21-31)33-16-18-34(19-17-33)29(36)20-27(25-12-7-4-8-13-25)35(30(37)38-2)22-24-10-5-3-6-11-24/h3-15,27-28H,16-20,22H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045957
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-prop-2-ynyl...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCC#C)c1ccccc1
Show InChI InChI=1S/C24H27N5O/c1-3-11-27-22(20-8-5-4-6-9-20)17-24(30)29-15-13-28(14-16-29)23(18-25)21-10-7-12-26-19(21)2/h1,4-10,12,22-23,27H,11,13-17H2,2H3
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n/an/a 270n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045987
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-pyrrolidin-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCCC1)c1ccccc1
Show InChI InChI=1S/C25H31N5O/c1-20-22(10-7-11-27-20)24(19-26)29-14-16-30(17-15-29)25(31)18-23(28-12-5-6-13-28)21-8-3-2-4-9-21/h2-4,7-11,23-24H,5-6,12-18H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045970
PNG
(CHEMBL102918 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O2/c1-21-24(13-8-14-30-21)26(20-29)32-15-17-33(18-16-32)27(34)19-25(22-9-4-2-5-10-22)31-28(35)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3,(H,31,35)
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair