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18 similar compounds to monomer 50045990

Compile data set for download or QSAR
Wt: 401.5
BDBM50045957
Wt: 457.5
BDBM50045966
Wt: 431.5
BDBM50045967
Wt: 543.7
BDBM50045969
Wt: 467.5
BDBM50045970
Wt: 405.4
BDBM50045977
Wt: 377.4
BDBM50045982
Wt: 469.5
BDBM50045984
Wt: 454.5
BDBM50045985
Wt: 417.5
BDBM50045987
Wt: 511.6
BDBM50045992
Wt: 460.5
BDBM50045994
Wt: 406.4
BDBM50046004
Wt: 363.4
BDBM50046005
Wt: 403.5
BDBM50046007
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50045957,50045966,50045967,50045969,50045970,50045977,50045982,50045984,50045985,50045987,50045992,50045994,50046004,50046005,50046007   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045970
PNG
(CHEMBL102918 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O2/c1-21-24(13-8-14-30-21)26(20-29)32-15-17-33(18-16-32)27(34)19-25(22-9-4-2-5-10-22)31-28(35)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3,(H,31,35)
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045982
PNG
(CHEMBL103596 | [4-(3-Methylamino-3-phenyl-propiony...)
Show SMILES CNC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-17-19(9-6-10-25-17)21(16-23)26-11-13-27(14-12-26)22(28)15-20(24-2)18-7-4-3-5-8-18/h3-10,20-21,24H,11-15H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045994
PNG
(CHEMBL100971 | Pyrrolidine-1-carboxylic acid (3-{4...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C26H32N6O2/c1-20-22(10-7-11-28-20)24(19-27)30-14-16-31(17-15-30)25(33)18-23(21-8-3-2-4-9-21)29-26(34)32-12-5-6-13-32/h2-4,7-11,23-24H,5-6,12-18H2,1H3,(H,29,34)
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n/an/a 64n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046004
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(N)=O)c1ccccc1
Show InChI InChI=1S/C22H26N6O2/c1-16-18(8-5-9-25-16)20(15-23)27-10-12-28(13-11-27)21(29)14-19(26-22(24)30)17-6-3-2-4-7-17/h2-9,19-20H,10-14H2,1H3,(H3,24,26,30)
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n/an/a 470n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045966
PNG
(CHEMBL99621 | Furan-3-carboxylic acid (3-{4-[cyano...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1ccoc1)c1ccccc1
Show InChI InChI=1S/C26H27N5O3/c1-19-22(8-5-10-28-19)24(17-27)30-11-13-31(14-12-30)25(32)16-23(20-6-3-2-4-7-20)29-26(33)21-9-15-34-18-21/h2-10,15,18,23-24H,11-14,16H2,1H3,(H,29,33)
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045985
PNG
((2-Methyl-pyridin-3-yl)-(4-{3-phenyl-3-[(pyridin-3...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCc1cccnc1)c1ccccc1
Show InChI InChI=1S/C27H30N6O/c1-21-24(10-6-12-30-21)26(18-28)32-13-15-33(16-14-32)27(34)17-25(23-8-3-2-4-9-23)31-20-22-7-5-11-29-19-22/h2-12,19,25-26,31H,13-17,20H2,1H3
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n/an/a 75n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045969
PNG
(CHEMBL103761 | [4-(3-Dibenzylamino-3-phenyl-propio...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N(Cc1ccccc1)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H37N5O/c1-28-32(18-11-19-37-28)34(25-36)38-20-22-39(23-21-38)35(41)24-33(31-16-9-4-10-17-31)40(26-29-12-5-2-6-13-29)27-30-14-7-3-8-15-30/h2-19,33-34H,20-24,26-27H2,1H3
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n/an/a 41n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045984
PNG
(CHEMBL100851 | Pyrazine-2-carboxylic acid (3-{4-[c...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1cnccn1)c1ccccc1
Show InChI InChI=1S/C26H27N7O2/c1-19-21(8-5-9-29-19)24(17-27)32-12-14-33(15-13-32)25(34)16-22(20-6-3-2-4-7-20)31-26(35)23-18-28-10-11-30-23/h2-11,18,22,24H,12-16H2,1H3,(H,31,35)
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n/an/a 820n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046005
PNG
(CHEMBL100853 | [4-(3-Amino-3-phenyl-propionyl)-pip...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-16-18(8-5-9-24-16)20(15-22)25-10-12-26(13-11-25)21(27)14-19(23)17-6-3-2-4-7-17/h2-9,19-20H,10-14,23H2,1H3
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n/an/a 740n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045977
PNG
(CHEMBL102774 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES CC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C23H27N5O2/c1-17-20(9-6-10-25-17)22(16-24)27-11-13-28(14-12-27)23(30)15-21(26-18(2)29)19-7-4-3-5-8-19/h3-10,21-22H,11-15H2,1-2H3,(H,26,29)
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n/an/a 31n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045967
PNG
((2-Methyl-pyridin-3-yl)-{4-[3-(2-oxo-pyrrolidin-1-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCCC1=O)c1ccccc1
Show InChI InChI=1S/C25H29N5O2/c1-19-21(9-5-11-27-19)23(18-26)28-13-15-29(16-14-28)25(32)17-22(20-7-3-2-4-8-20)30-12-6-10-24(30)31/h2-5,7-9,11,22-23H,6,10,12-17H2,1H3
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n/an/a 30n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045992
PNG
(Benzyl-(3-{4-[cyano-(2-methyl-pyridin-3-yl)-methyl...)
Show SMILES COC(=O)N(Cc1ccccc1)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C30H33N5O3/c1-23-26(14-9-15-32-23)28(21-31)33-16-18-34(19-17-33)29(36)20-27(25-12-7-4-8-13-25)35(30(37)38-2)22-24-10-5-3-6-11-24/h3-15,27-28H,16-20,22H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045957
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-prop-2-ynyl...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCC#C)c1ccccc1
Show InChI InChI=1S/C24H27N5O/c1-3-11-27-22(20-8-5-4-6-9-20)17-24(30)29-15-13-28(14-16-29)23(18-25)21-10-7-12-26-19(21)2/h1,4-10,12,22-23,27H,11,13-17H2,2H3
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n/an/a 270n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045987
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-pyrrolidin-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCCC1)c1ccccc1
Show InChI InChI=1S/C25H31N5O/c1-20-22(10-7-11-27-20)24(19-26)29-14-16-30(17-15-29)25(31)18-23(28-12-5-6-13-28)21-8-3-2-4-9-21/h2-4,7-11,23-24H,5-6,12-18H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046007
PNG
(CHEMBL103995 | [4-(3-Allylamino-3-phenyl-propionyl...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCC=C)c1ccccc1
Show InChI InChI=1S/C24H29N5O/c1-3-11-27-22(20-8-5-4-6-9-20)17-24(30)29-15-13-28(14-16-29)23(18-25)21-10-7-12-26-19(21)2/h3-10,12,22-23,27H,1,11,13-17H2,2H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair