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11 similar compounds to monomer 50045959

Compile data set for download or QSAR
Wt: 453.5
BDBM50045962
Wt: 469.5
BDBM50045975
Wt: 481.5
BDBM50045976
Wt: 453.5
BDBM50045981
Wt: 424.5
BDBM50045991
Wt: 453.5
BDBM50045997
Wt: 438.5
BDBM50046001
Wt: 475.5
BDBM50046002
Wt: 467.5
BDBM50046013
Wt: 453.5
BDBM50046018
Wt: 439.5
BDBM50046019

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50045962,50045975,50045976,50045981,50045991,50045997,50046001,50046002,50046013,50046018,50046019   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046013
PNG
(CHEMBL103571 | N-Benzhydryl-N-(2-{4-[cyano-(2-meth...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CN(C=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O2/c1-22-25(13-8-14-30-22)26(19-29)31-15-17-32(18-16-31)27(35)20-33(21-34)28(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-14,21,26,28H,15-18,20H2,1H3
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n/an/a 30n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045981
PNG
(CHEMBL103773 | {4-[2-(Benzhydryl-amino)-acetyl]-pi...)
Show SMILES CCc1ncccc1C(C#N)N1CCN(CC1)C(=O)CNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c1-2-25-24(14-9-15-30-25)26(20-29)32-16-18-33(19-17-32)27(34)21-31-28(22-10-5-3-6-11-22)23-12-7-4-8-13-23/h3-15,26,28,31H,2,16-19,21H2,1H3
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n/an/a 38n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046019
PNG
(CHEMBL100493 | {4-[2-(Benzhydryl-amino)-acetyl]-pi...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c1-21-24(13-8-14-29-21)25(19-28)31-15-17-32(18-16-31)26(33)20-30-27(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25,27,30H,15-18,20H2,1H3
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n/an/a 40n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046002
PNG
(CHEMBL318460 | [4-(2-{[Bis-(4-fluoro-phenyl)-methy...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CNC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F2N5O/c1-19-24(3-2-12-31-19)25(17-30)33-13-15-34(16-14-33)26(35)18-32-27(20-4-8-22(28)9-5-20)21-6-10-23(29)11-7-21/h2-12,25,27,32H,13-16,18H2,1H3
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n/an/a 150n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046018
PNG
(CHEMBL103408 | {4-[2-(Benzhydryl-amino)-propionyl]...)
Show SMILES C[C@@H](NC(c1ccccc1)c1ccccc1)C(=O)N1CCN(CC1)C(C#N)c1cccnc1C
Show InChI InChI=1S/C28H31N5O/c1-21-25(14-9-15-30-21)26(20-29)32-16-18-33(19-17-32)28(34)22(2)31-27(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-15,22,26-27,31H,16-19H2,1-2H3/t22-,26?/m1/s1
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n/an/a 30n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046001
PNG
(CHEMBL318159 | [4-(4,4-Diphenyl-butyryl)-piperazin...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H30N4O/c1-22-25(13-8-16-30-22)27(21-29)31-17-19-32(20-18-31)28(33)15-14-26(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-13,16,26-27H,14-15,17-20H2,1H3
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n/an/a 80n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045962
PNG
(CHEMBL100597 | {4-[3-(Benzhydryl-amino)-propionyl]...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CCNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c1-22-25(13-8-15-30-22)26(21-29)32-17-19-33(20-18-32)27(34)14-16-31-28(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-13,15,26,28,31H,14,16-20H2,1H3
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n/an/a 120n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045991
PNG
(CHEMBL100642 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O/c1-21-24(13-8-14-29-21)26(20-28)30-15-17-31(18-16-30)27(32)19-25(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045976
PNG
(CHEMBL100809 | N-Benzhydryl-N-(2-{4-[cyano-(2-meth...)
Show SMILES CC(=O)N(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-22-26(14-9-15-31-22)27(20-30)32-16-18-33(19-17-32)28(36)21-34(23(2)35)29(24-10-5-3-6-11-24)25-12-7-4-8-13-25/h3-15,27,29H,16-19,21H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045997
PNG
(CHEMBL103561 | {4-[2-(1,1-Diphenyl-ethylamino)-ace...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CNC(C)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c1-22-25(14-9-15-30-22)26(20-29)32-16-18-33(19-17-32)27(34)21-31-28(2,23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-15,26,31H,16-19,21H2,1-2H3
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n/an/a 86n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045975
PNG
(CHEMBL99795 | {4-[2-(Benzhydryl-amino)-3-hydroxy-p...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)[C@H](CO)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O2/c1-21-24(13-8-14-30-21)26(19-29)32-15-17-33(18-16-32)28(35)25(20-34)31-27(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25-27,31,34H,15-18,20H2,1H3/t25-,26?/m0/s1
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n/an/a 34n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair