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11 similar compounds to monomer 50045993

Compile data set for download or QSAR
Wt: 483.5
BDBM50045964
Wt: 405.4
BDBM50045977
Wt: 421.4
BDBM50045979
Purchase
Wt: 489.4
BDBM50045983
Wt: 433.5
BDBM50045986
Wt: 511.6
BDBM50045992
Wt: 435.5
BDBM50046003
Wt: 406.4
BDBM50046004
Wt: 463.5
BDBM50046010
Wt: 463.5
BDBM50046015
Wt: 497.5
BDBM50046020

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50045964,50045977,50045979,50045983,50045986,50045992,50046003,50046004,50046010,50046015,50046020   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045979
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES COC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C23H27N5O3/c1-17-19(9-6-10-25-17)21(16-24)27-11-13-28(14-12-27)22(29)15-20(26-23(30)31-2)18-7-4-3-5-8-18/h3-10,20-21H,11-15H2,1-2H3,(H,26,30)
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n/an/a 41n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046010
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)OC(C)(C)C)c1ccccc1
Show InChI InChI=1S/C26H33N5O3/c1-19-21(11-8-12-28-19)23(18-27)30-13-15-31(16-14-30)24(32)17-22(20-9-6-5-7-10-20)29-25(33)34-26(2,3)4/h5-12,22-23H,13-17H2,1-4H3,(H,29,33)
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n/an/a 56n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046015
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES CC(C)COC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C26H33N5O3/c1-19(2)18-34-26(33)29-23(21-8-5-4-6-9-21)16-25(32)31-14-12-30(13-15-31)24(17-27)22-10-7-11-28-20(22)3/h4-11,19,23-24H,12-16,18H2,1-3H3,(H,29,33)
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n/an/a 36n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045983
PNG
(CHEMBL103393 | [3-{4-[Cyano-(2-methyl-pyridin-3-yl...)
Show SMILES COC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O3/c1-16-19(4-3-9-29-16)21(15-28)31-10-12-32(13-11-31)22(33)14-20(30-23(34)35-2)17-5-7-18(8-6-17)24(25,26)27/h3-9,20-21H,10-14H2,1-2H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046004
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(N)=O)c1ccccc1
Show InChI InChI=1S/C22H26N6O2/c1-16-18(8-5-9-25-16)20(15-23)27-10-12-28(13-11-27)21(29)14-19(26-22(24)30)17-6-3-2-4-7-17/h2-9,19-20H,10-14H2,1H3,(H3,24,26,30)
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n/an/a 470n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045986
PNG
((2-Methyl-pyridin-3-yl)-{4-[3-(2-oxo-oxazolidin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCOC1=O)c1ccccc1
Show InChI InChI=1S/C24H27N5O3/c1-18-20(8-5-9-26-18)22(17-25)27-10-12-28(13-11-27)23(30)16-21(19-6-3-2-4-7-19)29-14-15-32-24(29)31/h2-9,21-22H,10-16H2,1H3
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n/an/a 63n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046020
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H31N5O3/c1-22-25(13-8-14-31-22)27(20-30)33-15-17-34(18-16-33)28(35)19-26(24-11-6-3-7-12-24)32-29(36)37-21-23-9-4-2-5-10-23/h2-14,26-27H,15-19,21H2,1H3,(H,32,36)
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n/an/a 22n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046003
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES COC(=O)N(C)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-18-20(10-7-11-26-18)22(17-25)28-12-14-29(15-13-28)23(30)16-21(27(2)24(31)32-3)19-8-5-4-6-9-19/h4-11,21-22H,12-16H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045977
PNG
(CHEMBL102774 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES CC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C23H27N5O2/c1-17-20(9-6-10-25-17)22(16-24)27-11-13-28(14-12-27)23(30)15-21(26-18(2)29)19-7-4-3-5-8-19/h3-10,21-22H,11-15H2,1-2H3,(H,26,29)
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n/an/a 31n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045992
PNG
(Benzyl-(3-{4-[cyano-(2-methyl-pyridin-3-yl)-methyl...)
Show SMILES COC(=O)N(Cc1ccccc1)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C30H33N5O3/c1-23-26(14-9-15-32-23)28(21-31)33-16-18-34(19-17-33)29(36)20-27(25-12-7-4-8-13-25)35(30(37)38-2)22-24-10-5-3-6-11-24/h3-15,27-28H,16-20,22H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045964
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)Oc1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-21-24(13-8-14-30-21)26(20-29)32-15-17-33(18-16-32)27(34)19-25(22-9-4-2-5-10-22)31-28(35)36-23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3,(H,31,35)
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n/an/a 16n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair