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11 similar compounds to monomer 82431

Compile data set for download or QSAR
Wt: 661.8
BDBM50049181
Wt: 675.8
BDBM50282458
Wt: 548.6
BDBM50282459
Wt: 605.7
BDBM50282461
Wt: 632.7
BDBM50282462
Wt: 633.7
BDBM50282464
Wt: 647.7
BDBM50282465
Wt: 661.8
BDBM50282466
Wt: 619.7
BDBM50282472
Wt: 633.7
BDBM50282452
Wt: 647.7
BDBM50282453

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50049181,50282458,50282459,50282461,50282462,50282464,50282465,50282466,50282472,50282452,50282453   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282461
PNG
(CHEMBL168490 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1
Show InChI InChI=1S/C31H35N5O6S/c1-4-6-18-42-31(39)35-43(40,41)27-11-8-7-10-24(27)22-14-12-21(13-15-22)20-36-28(9-5-2)34-26-17-16-23(33-30(38)32-3)19-25(26)29(36)37/h7-8,10-17,19H,4-6,9,18,20H2,1-3H3,(H,35,39)(H2,32,33,38)
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n/an/a 0.260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibitory activity at Angiotensin II type 2 receptor.


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282465
PNG
(CHEMBL353615 | Quinazolinone Analog)
Show SMILES CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3S(=O)(=O)NC(=O)OCCCC)c(=O)c2c1
Show InChI InChI=1S/C34H41N5O6S/c1-4-7-20-35-33(41)36-26-18-19-29-28(22-26)32(40)39(31(37-29)11-6-3)23-24-14-16-25(17-15-24)27-12-9-10-13-30(27)46(43,44)38-34(42)45-21-8-5-2/h9-10,12-19,22H,4-8,11,20-21,23H2,1-3H3,(H,38,42)(H2,35,36,41)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282458
PNG
(CHEMBL352947 | Quinazolinone Analog)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H45N5O6S/c1-7-8-13-33-38-31-19-18-28(37-35(43)40(6)25(4)5)22-30(31)34(42)41(33)23-26-14-16-27(17-15-26)29-11-9-10-12-32(29)48(45,46)39-36(44)47-21-20-24(2)3/h9-12,14-19,22,24-25H,7-8,13,20-21,23H2,1-6H3,(H,37,43)(H,39,44)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282472
PNG
(CHEMBL169221 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
Show InChI InChI=1S/C32H37N5O6S/c1-4-7-19-43-32(40)36-44(41,42)28-12-9-8-11-25(28)23-15-13-22(14-16-23)21-37-29(10-5-2)35-27-18-17-24(20-26(27)30(37)38)34-31(39)33-6-3/h8-9,11-18,20H,4-7,10,19,21H2,1-3H3,(H,36,40)(H2,33,34,39)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282462
PNG
(CHEMBL352503 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1
Show InChI InChI=1S/C34H40N4O6S/c1-4-7-14-32(39)35-26-19-20-29-28(22-26)33(40)38(31(36-29)11-6-3)23-24-15-17-25(18-16-24)27-12-9-10-13-30(27)45(42,43)37-34(41)44-21-8-5-2/h9-10,12-13,15-20,22H,4-8,11,14,21,23H2,1-3H3,(H,35,39)(H,37,41)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282452
PNG
(CHEMBL169488 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
Show InChI InChI=1S/C33H39N5O6S/c1-4-7-13-30-36-28-19-18-25(35-32(40)34-6-3)21-27(28)31(39)38(30)22-23-14-16-24(17-15-23)26-11-9-10-12-29(26)45(42,43)37-33(41)44-20-8-5-2/h9-12,14-19,21H,4-8,13,20,22H2,1-3H3,(H,37,41)(H2,34,35,40)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282466
PNG
(CHEMBL354779 | Quinazolinone Analog)
Show SMILES CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-5-7-11-21-46-35(43)39-47(44,45)31-13-10-9-12-28(31)26-17-15-25(16-18-26)23-40-32(14-8-6-2)38-30-20-19-27(22-29(30)33(40)41)37-34(42)36-24(3)4/h9-10,12-13,15-20,22,24H,5-8,11,14,21,23H2,1-4H3,(H,39,43)(H2,36,37,42)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282453
PNG
(CHEMBL353800 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C34H41N5O6S/c1-5-7-13-31-37-29-19-18-26(36-33(41)35-23(3)4)21-28(29)32(40)39(31)22-24-14-16-25(17-15-24)27-11-9-10-12-30(27)46(43,44)38-34(42)45-20-8-6-2/h9-12,14-19,21,23H,5-8,13,20,22H2,1-4H3,(H,38,42)(H2,35,36,41)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282459
PNG
(CHEMBL169009 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1
Show InChI InChI=1S/C29H32N4O5S/c1-3-5-17-38-29(35)32-39(36,37)26-10-7-6-9-23(26)21-13-11-20(12-14-21)19-33-27(8-4-2)31-25-16-15-22(30)18-24(25)28(33)34/h6-7,9-16,18H,3-5,8,17,19,30H2,1-2H3,(H,32,35)
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TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 0.240n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane


Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rat adrenal membrane


Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane


Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane


Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282453
PNG
(CHEMBL353800 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C34H41N5O6S/c1-5-7-13-31-37-29-19-18-26(36-33(41)35-23(3)4)21-28(29)32(40)39(31)22-24-14-16-25(17-15-24)27-11-9-10-12-30(27)46(43,44)38-34(42)45-20-8-6-2/h9-12,14-19,21,23H,5-8,13,20,22H2,1-4H3,(H,38,42)(H2,35,36,41)
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n/an/a 3.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282458
PNG
(CHEMBL352947 | Quinazolinone Analog)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H45N5O6S/c1-7-8-13-33-38-31-19-18-28(37-35(43)40(6)25(4)5)22-30(31)34(42)41(33)23-26-14-16-27(17-15-26)29-11-9-10-12-32(29)48(45,46)39-36(44)47-21-20-24(2)3/h9-12,14-19,22,24-25H,7-8,13,20-21,23H2,1-6H3,(H,37,43)(H,39,44)
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n/an/a 1.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282459
PNG
(CHEMBL169009 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1
Show InChI InChI=1S/C29H32N4O5S/c1-3-5-17-38-29(35)32-39(36,37)26-10-7-6-9-23(26)21-13-11-20(12-14-21)19-33-27(8-4-2)31-25-16-15-22(30)18-24(25)28(33)34/h6-7,9-16,18H,3-5,8,17,19,30H2,1-2H3,(H,32,35)
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n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282461
PNG
(CHEMBL168490 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1
Show InChI InChI=1S/C31H35N5O6S/c1-4-6-18-42-31(39)35-43(40,41)27-11-8-7-10-24(27)22-14-12-21(13-15-22)20-36-28(9-5-2)34-26-17-16-23(33-30(38)32-3)19-25(26)29(36)37/h7-8,10-17,19H,4-6,9,18,20H2,1-3H3,(H,35,39)(H2,32,33,38)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282462
PNG
(CHEMBL352503 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1
Show InChI InChI=1S/C34H40N4O6S/c1-4-7-14-32(39)35-26-19-20-29-28(22-26)33(40)38(31(36-29)11-6-3)23-24-15-17-25(18-16-24)27-12-9-10-13-30(27)45(42,43)37-34(41)44-21-8-5-2/h9-10,12-13,15-20,22H,4-8,11,14,21,23H2,1-3H3,(H,35,39)(H,37,41)
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n/an/a 5.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282466
PNG
(CHEMBL354779 | Quinazolinone Analog)
Show SMILES CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-5-7-11-21-46-35(43)39-47(44,45)31-13-10-9-12-28(31)26-17-15-25(16-18-26)23-40-32(14-8-6-2)38-30-20-19-27(22-29(30)33(40)41)37-34(42)36-24(3)4/h9-10,12-13,15-20,22,24H,5-8,11,14,21,23H2,1-4H3,(H,39,43)(H2,36,37,42)
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n/an/a 2.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282465
PNG
(CHEMBL353615 | Quinazolinone Analog)
Show SMILES CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3S(=O)(=O)NC(=O)OCCCC)c(=O)c2c1
Show InChI InChI=1S/C34H41N5O6S/c1-4-7-20-35-33(41)36-26-18-19-29-28(22-26)32(40)39(31(37-29)11-6-3)23-24-14-16-25(17-15-24)27-12-9-10-13-30(27)46(43,44)38-34(42)45-21-8-5-2/h9-10,12-19,22H,4-8,11,20-21,23H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 4.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282464
PNG
(CHEMBL169568 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1
Show InChI InChI=1S/C33H39N5O6S/c1-4-7-20-44-33(41)37-45(42,43)29-12-9-8-11-26(29)24-15-13-23(14-16-24)22-38-30(10-5-2)36-28-18-17-25(21-27(28)31(38)39)35-32(40)34-19-6-3/h8-9,11-18,21H,4-7,10,19-20,22H2,1-3H3,(H,37,41)(H2,34,35,40)
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n/an/a 3.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282472
PNG
(CHEMBL169221 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
Show InChI InChI=1S/C32H37N5O6S/c1-4-7-19-43-32(40)36-44(41,42)28-12-9-8-11-25(28)23-15-13-22(14-16-23)21-37-29(10-5-2)35-27-18-17-24(20-26(27)30(37)38)34-31(39)33-6-3/h8-9,11-18,20H,4-7,10,19,21H2,1-3H3,(H,36,40)(H2,33,34,39)
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n/an/a 6.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282452
PNG
(CHEMBL169488 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
Show InChI InChI=1S/C33H39N5O6S/c1-4-7-13-30-36-28-19-18-25(35-32(40)34-6-3)21-27(28)31(39)38(30)22-23-14-16-24(17-15-23)26-11-9-10-12-29(26)45(42,43)37-33(41)44-20-8-5-2/h9-12,14-19,21H,4-8,13,20,22H2,1-3H3,(H,37,41)(H2,34,35,40)
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n/an/a 7.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282464
PNG
(CHEMBL169568 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1
Show InChI InChI=1S/C33H39N5O6S/c1-4-7-20-44-33(41)37-45(42,43)29-12-9-8-11-26(29)24-15-13-23(14-16-24)22-38-30(10-5-2)36-28-18-17-25(21-27(28)31(38)39)35-32(40)34-19-6-3/h8-9,11-18,21H,4-7,10,19-20,22H2,1-3H3,(H,37,41)(H2,34,35,40)
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n/an/a 0.180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair