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64 similar compounds to monomer 50066499

Compile data set for download or QSAR
Wt: 425.9
BDBM50066739
Wt: 390.4
BDBM50066751
Wt: 386.8
BDBM50066759
Wt: 415.9
BDBM50066501
Wt: 403.8
BDBM50066504
Wt: 403.8
BDBM50066668
Wt: 436.3
BDBM50066719
Wt: 406.4
BDBM50066750
Wt: 438.3
BDBM50066722
Wt: 428.9
BDBM50066439
Wt: 427.9
BDBM50066440
Wt: 453.8
BDBM50066442
Wt: 453.8
BDBM50066443
Wt: 410.8
BDBM50066498
Wt: 415.9
BDBM50066500
Displayed 1 to 15 (of 64 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50066739,50066751,50066759,50066501,50066504,50066668,50066719,50066750,50066722,50066439,50066440,50066442,50066443,50066498,50066500   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066751
PNG
(CHEMBL3403094)
Show SMILES Cc1ccc(cc1)-c1c(sc2ncccc12)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C21H14N2O2S2/c1-14-7-9-16(10-8-14)19-18-6-3-11-23-20(18)26-21(19)27(24,25)17-5-2-4-15(12-17)13-22/h2-12H,1H3
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3n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066498
PNG
(CHEMBL3401580)
Show SMILES Clc1ccc(cc1)-c1c(sc2ncccc12)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C20H11ClN2O2S2/c21-15-8-6-14(7-9-15)18-17-5-2-10-23-19(17)26-20(18)27(24,25)16-4-1-3-13(11-16)12-22/h1-11H
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4.10n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066739
PNG
(CHEMBL3403117)
Show SMILES Nc1cnc2sc(c(-c3ccc(Cl)cc3)c2c1)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C20H12ClN3O2S2/c21-14-6-4-13(5-7-14)18-17-9-15(23)11-24-19(17)27-20(18)28(25,26)16-3-1-2-12(8-16)10-22/h1-9,11H,23H2
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9n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066500
PNG
(CHEMBL3401578)
Show SMILES COc1cccc(c1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClNO3S2/c1-25-15-4-2-5-16(12-15)27(23,24)20-18(13-7-9-14(21)10-8-13)17-6-3-11-22-19(17)26-20/h2-12H,1H3
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9.5n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066501
PNG
(CHEMBL3401577)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClNO3S2/c1-25-15-8-10-16(11-9-15)27(23,24)20-18(13-4-6-14(21)7-5-13)17-3-2-12-22-19(17)26-20/h2-12H,1H3
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20n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066750
PNG
(CHEMBL3403096)
Show SMILES COc1ccc(cc1)-c1c(sc2ncccc12)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C21H14N2O3S2/c1-26-16-9-7-15(8-10-16)19-18-6-3-11-23-20(18)27-21(19)28(24,25)17-5-2-4-14(12-17)13-22/h2-12H,1H3
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23n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066722
PNG
(CHEMBL3403134)
Show SMILES Fc1ccc2c(c(sc2n1)S(=O)(=O)c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10Cl2FNO2S2/c20-12-3-1-11(2-4-12)17-15-9-10-16(22)23-18(15)26-19(17)27(24,25)14-7-5-13(21)6-8-14/h1-10H
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26n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066668
PNG
(CHEMBL3403083)
Show SMILES Fc1cccc(c1)-c1c(sc2ncccc12)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11ClFNO2S2/c20-13-6-8-15(9-7-13)26(23,24)19-17(12-3-1-4-14(21)11-12)16-5-2-10-22-18(16)25-19/h1-11H
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38n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066504
PNG
(CHEMBL3401574)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11ClFNO2S2/c20-13-8-6-12(7-9-13)17-16-5-2-10-22-18(16)25-19(17)26(23,24)15-4-1-3-14(21)11-15/h1-11H
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43n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066439
PNG
(CHEMBL3401585)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN2O2S2/c1-24(2)16-9-11-17(12-10-16)28(25,26)21-19(14-5-7-15(22)8-6-14)18-4-3-13-23-20(18)27-21/h3-13H,1-2H3
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52n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066442
PNG
(CHEMBL3401582)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H11ClF3NO2S2/c21-14-8-6-12(7-9-14)17-16-5-2-10-25-18(16)28-19(17)29(26,27)15-4-1-3-13(11-15)20(22,23)24/h1-11H
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54n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066719
PNG
(CHEMBL3403136)
Show SMILES Oc1ccc2c(c(sc2n1)S(=O)(=O)c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11Cl2NO3S2/c20-12-3-1-11(2-4-12)17-15-9-10-16(23)22-18(15)26-19(17)27(24,25)14-7-5-13(21)6-8-14/h1-10H,(H,22,23)
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60n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066440
PNG
(CHEMBL3401583)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClNO2S2/c1-14(2)15-7-11-18(12-8-15)28(25,26)22-20(16-5-9-17(23)10-6-16)19-4-3-13-24-21(19)27-22/h3-14H,1-2H3
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66n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066443
PNG
(CHEMBL3401581)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1sc2ncccc2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H11ClF3NO2S2/c21-14-7-3-12(4-8-14)17-16-2-1-11-25-18(16)28-19(17)29(26,27)15-9-5-13(6-10-15)20(22,23)24/h1-11H
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272n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066759
PNG
(CHEMBL3401597)
Show SMILES Clc1ccc(cc1)-c1c(sc2ncccc12)S(=O)(=O)c1cccnc1
Show InChI InChI=1S/C18H11ClN2O2S2/c19-13-7-5-12(6-8-13)16-15-4-2-10-21-17(15)24-18(16)25(22,23)14-3-1-9-20-11-14/h1-11H
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289n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat cerebrocortical mGluR5 receptor


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066722
PNG
(CHEMBL3403134)
Show SMILES Fc1ccc2c(c(sc2n1)S(=O)(=O)c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10Cl2FNO2S2/c20-12-3-1-11(2-4-12)17-15-9-10-16(22)23-18(15)26-19(17)27(24,25)14-7-5-13(21)6-8-14/h1-10H
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n/an/a 172n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066719
PNG
(CHEMBL3403136)
Show SMILES Oc1ccc2c(c(sc2n1)S(=O)(=O)c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11Cl2NO3S2/c20-12-3-1-11(2-4-12)17-15-9-10-16(23)22-18(15)26-19(17)27(24,25)14-7-5-13(21)6-8-14/h1-10H,(H,22,23)
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n/an/a 338n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066498
PNG
(CHEMBL3401580)
Show SMILES Clc1ccc(cc1)-c1c(sc2ncccc12)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C20H11ClN2O2S2/c21-15-8-6-14(7-9-15)18-17-5-2-10-23-19(17)26-20(18)27(24,25)16-4-1-3-13(11-16)12-22/h1-11H
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n/an/a 30n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50066668
PNG
(CHEMBL3403083)
Show SMILES Fc1cccc(c1)-c1c(sc2ncccc12)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11ClFNO2S2/c20-13-6-8-15(9-7-13)26(23,24)19-17(12-3-1-4-14(21)11-12)16-5-2-10-22-18(16)25-19/h1-11H
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n/an/a 123n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Bioorg Med Chem Lett 25: 1724-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.073
BindingDB Entry DOI: 10.7270/Q2JS9S47
More data for this
Ligand-Target Pair