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2 similar compounds to monomer 50074300

Compile data set for download or QSAR
Wt: 401.4
BDBM50051552
Wt: 351.4
BDBM50074302

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50051552,50074302   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid receptor


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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PubMed
3.36E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-beta in baculoviral sysytem, by using 5 nM [3H]-targretin in a competitiv...


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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4.23E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-alpha in baculoviral sysytem, by using 5 nM [3H]-targretin in a competiti...


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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5.05E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-gamma in baculoviral sysytem, by using 5 nM [3H]-targretin in a competiti...


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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n/an/an/an/a 2.89E+3n/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50051552
PNG
(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
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n/an/an/a 3.30n/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay


J Med Chem 39: 2411-21 (1996)


Article DOI: 10.1021/jm9502293
BindingDB Entry DOI: 10.7270/Q2MS3RVK
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50051552
PNG
(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
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n/an/an/a 50n/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay


J Med Chem 39: 2411-21 (1996)


Article DOI: 10.1021/jm9502293
BindingDB Entry DOI: 10.7270/Q2MS3RVK
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50051552
PNG
(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
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n/an/an/a 700n/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assay


J Med Chem 39: 2411-21 (1996)


Article DOI: 10.1021/jm9502293
BindingDB Entry DOI: 10.7270/Q2MS3RVK
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50074302
PNG
(4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)19(23-26)14-5-7-15(8-6-14)20(24)25/h5-10,13,19H,11-12H2,1-4H3,(H,24,25)
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n/an/an/an/a 2.96E+3n/an/an/an/a



Ligand Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha


J Med Chem 42: 742-50 (1999)


Article DOI: 10.1021/jm980621r
BindingDB Entry DOI: 10.7270/Q2K936Q1
More data for this
Ligand-Target Pair