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4 similar compounds to monomer 50071156

Compile data set for download or QSAR
Wt: 174.1
BDBM50052398
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Wt: 270.3
BDBM50071160
Wt: 188.1
BDBM50071164
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Wt: 232.1
BDBM50102128

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50052398,50071160,50071164,50102128   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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410n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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450n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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2.73E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




J Pharmacol Exp Ther 298: 453-60 (2001)


Article DOI: 10.1016/j.bioorg.2016.02.004
BindingDB Entry DOI: 10.7270/Q2V986M2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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1.10E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 200n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor


Bioorg Med Chem Lett 9: 1721-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00266-8
BindingDB Entry DOI: 10.7270/Q2V69K37
More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)


Article DOI: 10.1021/jm049092j
BindingDB Entry DOI: 10.7270/Q23X87FM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50102128
PNG
((2R,4R)-4-amino-1-(carboxymethyl)pyrrolidine-2,4-d...)
Show SMILES N[C@@]1(C[C@@H](N(CC(O)=O)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H12N2O6/c9-8(7(15)16)1-4(6(13)14)10(3-8)2-5(11)12/h4H,1-3,9H2,(H,11,12)(H,13,14)(H,15,16)/t4-,8-/m1/s1
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n/an/an/an/a 610n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Effective concentration required for partial agonistic activity at Metabotropic glutamate receptor 2; Partial agonist


Bioorg Med Chem Lett 11: 1919-24 (2001)


Article DOI: 10.1016/s0960-894x(01)00329-8
BindingDB Entry DOI: 10.7270/Q2SQ90XH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 480n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2


Bioorg Med Chem Lett 11: 1919-24 (2001)


Article DOI: 10.1016/s0960-894x(01)00329-8
BindingDB Entry DOI: 10.7270/Q2SQ90XH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the agonistic activity against Metabotropic glutamate receptor 2


Bioorg Med Chem Lett 7: 601-606 (1997)


Article DOI: 10.1016/S0960-894X(97)00068-1
BindingDB Entry DOI: 10.7270/Q27944QG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071160
PNG
((2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4...)
Show SMILES N[C@@]1(C[C@@H](N(CC2CCCCC2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H22N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h9-10H,1-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071160
PNG
((2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4...)
Show SMILES N[C@@]1(C[C@@H](N(CC2CCCCC2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H22N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h9-10H,1-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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n/an/a 4.62E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50071160
PNG
((2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4...)
Show SMILES N[C@@]1(C[C@@H](N(CC2CCCCC2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H22N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h9-10H,1-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071160
PNG
((2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4...)
Show SMILES N[C@@]1(C[C@@H](N(CC2CCCCC2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H22N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h9-10H,1-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor


Bioorg Med Chem Lett 9: 1721-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00266-8
BindingDB Entry DOI: 10.7270/Q2V69K37
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3


Bioorg Med Chem Lett 11: 1919-24 (2001)


Article DOI: 10.1016/s0960-894x(01)00329-8
BindingDB Entry DOI: 10.7270/Q2SQ90XH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 2.00E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the agonistic activity against Metabotropic glutamate receptor 5


Bioorg Med Chem Lett 7: 601-606 (1997)


Article DOI: 10.1016/S0960-894X(97)00068-1
BindingDB Entry DOI: 10.7270/Q27944QG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 1.10E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the agonistic activity against Metabotropic glutamate receptor 6


Bioorg Med Chem Lett 7: 601-606 (1997)


Article DOI: 10.1016/S0960-894X(97)00068-1
BindingDB Entry DOI: 10.7270/Q27944QG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 1.00E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the agonistic activity against Metabotropic glutamate receptor 1


Bioorg Med Chem Lett 7: 601-606 (1997)


Article DOI: 10.1016/S0960-894X(97)00068-1
BindingDB Entry DOI: 10.7270/Q27944QG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair