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6 similar compounds to monomer 50061008

Compile data set for download or QSAR
Wt: 287.4
BDBM50061009
Wt: 261.3
BDBM50061010
Wt: 261.3
BDBM50061011
Wt: 249.3
BDBM50061013
Wt: 249.3
BDBM50061014
Wt: 287.4
BDBM50061007

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50061009,50061010,50061011,50061013,50061014,50061007   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061007
PNG
(CHEMBL3393557)
Show SMILES CN[C@H]1CCN(C1)c1cnnc(NC2CC3CCC2C3)c1
Show InChI InChI=1S/C16H25N5/c1-17-13-4-5-21(10-13)14-8-16(20-18-9-14)19-15-7-11-2-3-12(15)6-11/h8-9,11-13,15,17H,2-7,10H2,1H3,(H,19,20)/t11?,12?,13-,15?/m0/s1
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061011
PNG
(CHEMBL3393553)
Show SMILES CN[C@@H]1CCN(C1)c1cnnc(NC2CCCC2)c1
Show InChI InChI=1S/C14H23N5/c1-15-12-6-7-19(10-12)13-8-14(18-16-9-13)17-11-4-2-3-5-11/h8-9,11-12,15H,2-7,10H2,1H3,(H,17,18)/t12-/m1/s1
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6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061014
PNG
(CHEMBL3393550 | US9732087, 95)
Show SMILES CN[C@@H]1CCN(C1)c1cnnc(NCC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-10(2)7-15-13-6-12(8-16-17-13)18-5-4-11(9-18)14-3/h6,8,10-11,14H,4-5,7,9H2,1-3H3,(H,15,17)/t11-/m1/s1
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US Patent
15n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA N.V.

US Patent


Assay Description
Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...


US Patent US9732087 (2017)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061014
PNG
(CHEMBL3393550 | US9732087, 95)
Show SMILES CN[C@@H]1CCN(C1)c1cnnc(NCC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-10(2)7-15-13-6-12(8-16-17-13)18-5-4-11(9-18)14-3/h6,8,10-11,14H,4-5,7,9H2,1-3H3,(H,15,17)/t11-/m1/s1
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55n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061010
PNG
(CHEMBL3393554)
Show SMILES CN[C@H]1CCN(C1)c1cnnc(NC2CCCC2)c1
Show InChI InChI=1S/C14H23N5/c1-15-12-6-7-19(10-12)13-8-14(18-16-9-13)17-11-4-2-3-5-11/h8-9,11-12,15H,2-7,10H2,1H3,(H,17,18)/t12-/m0/s1
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240n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061009
PNG
(CHEMBL3393555)
Show SMILES CN1CCN(CC1)c1cnnc(NC2CC3CCC2C3)c1
Show InChI InChI=1S/C16H25N5/c1-20-4-6-21(7-5-20)14-10-16(19-17-11-14)18-15-9-12-2-3-13(15)8-12/h10-13,15H,2-9H2,1H3,(H,18,19)
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365n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061013
PNG
(CHEMBL3393551)
Show SMILES CN[C@H]1CCN(C1)c1cnnc(NCC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-10(2)7-15-13-6-12(8-16-17-13)18-5-4-11(9-18)14-3/h6,8,10-11,14H,4-5,7,9H2,1-3H3,(H,15,17)/t11-/m0/s1
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Article
PubMed
389n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061007
PNG
(CHEMBL3393557)
Show SMILES CN[C@H]1CCN(C1)c1cnnc(NC2CC3CCC2C3)c1
Show InChI InChI=1S/C16H25N5/c1-17-13-4-5-21(10-13)14-8-16(20-18-9-14)19-15-7-11-2-3-12(15)6-11/h8-9,11-13,15,17H,2-7,10H2,1H3,(H,19,20)/t11?,12?,13-,15?/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061014
PNG
(CHEMBL3393550 | US9732087, 95)
Show SMILES CN[C@@H]1CCN(C1)c1cnnc(NCC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-10(2)7-15-13-6-12(8-16-17-13)18-5-4-11(9-18)14-3/h6,8,10-11,14H,4-5,7,9H2,1-3H3,(H,15,17)/t11-/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair