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13 similar compounds to monomer 50452945

Compile data set for download or QSAR
Wt: 322.4
BDBM50452929
Wt: 322.4
BDBM50452937
Wt: 310.3
BDBM50452941
Wt: 334.4
BDBM50452957
Wt: 322.4
BDBM50452960
Wt: 294.3
BDBM50452961
Wt: 322.4
BDBM50452970
Wt: 294.3
BDBM50452944
Wt: 296.3
BDBM50452952
Wt: 438.3
BDBM50452969
Wt: 326.3
BDBM50452928
Wt: 322.4
BDBM50452972
Wt: 308.3
BDBM50062446

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50452929,50452937,50452941,50452957,50452960,50452961,50452970,50452944,50452952,50452969,50452928,50452972,50062446   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex.


J Med Chem 41: 311-7 (1998)


Article DOI: 10.1021/jm9705418
BindingDB Entry DOI: 10.7270/Q2N29XMV
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452928
PNG
(CHEMBL288898)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2cc(F)ccc12
Show InChI InChI=1S/C18H19FN4O/c1-22-9-15(13-8-12(19)2-3-16(13)22)17-20-18(24-21-17)14-10-23-6-4-11(14)5-7-23/h2-3,8-9,11,14H,4-7,10H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452970
PNG
(CHEMBL36478)
Show SMILES CN1C2CCC1CC(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-11-16(15-5-3-4-6-17(15)22)18-20-19(24-21-18)12-9-13-7-8-14(10-12)23(13)2/h3-6,11-14H,7-10H2,1-2H3
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n/an/a 191n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452961
PNG
(CHEMBL37802)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-2-4-15-12(3-1)13(9-18-15)16-19-17(22-20-16)14-10-21-7-5-11(14)6-8-21/h1-4,9,11,14,18H,5-8,10H2
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n/an/a 2.70n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452941
PNG
(CHEMBL36601)
Show SMILES Cn1cc(-c2noc(CCN3CCCCC3)n2)c2ccccc12
Show InChI InChI=1S/C18H22N4O/c1-21-13-15(14-7-3-4-8-16(14)21)18-19-17(23-20-18)9-12-22-10-5-2-6-11-22/h3-4,7-8,13H,2,5-6,9-12H2,1H3
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n/an/a 372n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452960
PNG
(CHEMBL286001)
Show SMILES Cc1ccc2n(C)cc(-c3noc(n3)C3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C19H22N4O/c1-12-3-4-17-14(9-12)16(10-22(17)2)18-20-19(24-21-18)15-11-23-7-5-13(15)6-8-23/h3-4,9-10,13,15H,5-8,11H2,1-2H3
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n/an/a 331n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452937
PNG
(CHEMBL35645)
Show SMILES Cc1cccc2c(cn(C)c12)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C19H22N4O/c1-12-4-3-5-14-16(10-22(2)17(12)14)18-20-19(24-21-18)15-11-23-8-6-13(15)7-9-23/h3-5,10,13,15H,6-9,11H2,1-2H3
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n/an/a 95n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452957
PNG
(CHEMBL34435)
Show SMILES C=CCn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C20H22N4O/c1-2-9-24-13-17(15-5-3-4-6-18(15)24)19-21-20(25-22-19)16-12-23-10-7-14(16)8-11-23/h2-6,13-14,16H,1,7-12H2
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor in rat brain membranes


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452969
PNG
(CHEMBL287685)
Show SMILES Cn1cc(-c2noc(n2)C2CCC[N+](C)(C)C2)c2ccccc12
Show InChI InChI=1S/C18H23N4O.HI/c1-21-11-15(14-8-4-5-9-16(14)21)17-19-18(23-20-17)13-7-6-10-22(2,3)12-13;/h4-5,8-9,11,13H,6-7,10,12H2,1-3H3;1H/q+1;/p-1
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n/an/a 35n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 7.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452972
PNG
(CHEMBL37237)
Show SMILES Cn1cc(-c2noc(CC3CN4CCC3CC4)n2)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-12-16(15-4-2-3-5-17(15)22)19-20-18(24-21-19)10-14-11-23-8-6-13(14)7-9-23/h2-5,12-14H,6-11H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 224n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452952
PNG
(CHEMBL36808)
Show SMILES CN1CCCC(C1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-20-9-5-6-12(10-20)17-18-16(19-22-17)14-11-21(2)15-8-4-3-7-13(14)15/h3-4,7-8,11-12H,5-6,9-10H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


J Med Chem 34: 140-51 (1991)


Article DOI: 10.1021/jm00105a021
BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair