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12 similar compounds to monomer 50062520

Compile data set for download or QSAR
Wt: 339.3
BDBM50455206
Wt: 353.4
BDBM50062510
Wt: 297.7
BDBM50062518
Wt: 281.2
BDBM50062526
Wt: 331.2
BDBM50062538
Wt: 278.3
BDBM50062539
Wt: 339.3
BDBM50062543
Wt: 313.3
BDBM50408687
Wt: 291.3
BDBM50408690
Wt: 277.3
BDBM50408692
Wt: 263.2
BDBM50408693
Wt: 307.2
BDBM50408697

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50455206,50062510,50062518,50062526,50062538,50062539,50062543,50408687,50408690,50408692,50408693,50408697   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062510
PNG
((S)-2-((R)-1-Amino-1-carboxy-4,4-diphenyl-butyl)-c...)
Show SMILES N[C@](CCC(c1ccccc1)c1ccccc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H23NO4/c22-21(20(25)26,18-13-17(18)19(23)24)12-11-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-18H,11-13,22H2,(H,23,24)(H,25,26)/t17-,18?,21+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408697
PNG
(CHEMBL2112634)
Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50455206
PNG
(CHEMBL2311086)
Show SMILES N[C@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20+/m0/s1
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n/an/a 4.36E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408697
PNG
(CHEMBL2112634)
Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062510
PNG
((S)-2-((R)-1-Amino-1-carboxy-4,4-diphenyl-butyl)-c...)
Show SMILES N[C@](CCC(c1ccccc1)c1ccccc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H23NO4/c22-21(20(25)26,18-13-17(18)19(23)24)12-11-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-18H,11-13,22H2,(H,23,24)(H,25,26)/t17-,18?,21+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062518
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)
Show SMILES N[C@](CCc1cccc(Cl)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062526
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)
Show SMILES N[C@](CCc1ccc(F)cc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-9-3-1-8(2-4-9)5-6-14(16,13(19)20)11-7-10(11)12(17)18/h1-4,10-11H,5-7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062526
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)
Show SMILES N[C@](CCc1ccc(F)cc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-9-3-1-8(2-4-9)5-6-14(16,13(19)20)11-7-10(11)12(17)18/h1-4,10-11H,5-7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062518
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)
Show SMILES N[C@](CCc1cccc(Cl)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062539
PNG
((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)
Show SMILES Nc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C14H18N2O4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,15-16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062543
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)
Show SMILES N[C@@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062543
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)
Show SMILES N[C@@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062538
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)
Show SMILES N[C@](CCc1cccc(c1)C(F)(F)F)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)9-3-1-2-8(6-9)4-5-14(19,13(22)23)11-7-10(11)12(20)21/h1-3,6,10-11H,4-5,7,19H2,(H,20,21)(H,22,23)/t10-,11?,14+/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062539
PNG
((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)
Show SMILES Nc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C14H18N2O4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,15-16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50062538
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)
Show SMILES N[C@](CCc1cccc(c1)C(F)(F)F)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)9-3-1-2-8(6-9)4-5-14(19,13(22)23)11-7-10(11)12(20)21/h1-3,6,10-11H,4-5,7,19H2,(H,20,21)(H,22,23)/t10-,11?,14+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408687
PNG
(CHEMBL2112583)
Show SMILES NC(CCc1cccc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-18(17(22)23,15-10-14(15)16(20)21)9-8-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14-15H,8-10,19H2,(H,20,21)(H,22,23)/t14-,15-,18?/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408690
PNG
(CHEMBL2112585)
Show SMILES NC(CCCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C16H21NO4/c17-16(15(20)21,13-10-12(13)14(18)19)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,17H2,(H,18,19)(H,20,21)/t12-,13-,16?/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408692
PNG
(CHEMBL2112584)
Show SMILES NC(CCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO4/c16-15(14(19)20,12-9-11(12)13(17)18)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,17,18)(H,19,20)/t11-,12-,15?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408687
PNG
(CHEMBL2112583)
Show SMILES NC(CCc1cccc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-18(17(22)23,15-10-14(15)16(20)21)9-8-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14-15H,8-10,19H2,(H,20,21)(H,22,23)/t14-,15-,18?/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408690
PNG
(CHEMBL2112585)
Show SMILES NC(CCCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C16H21NO4/c17-16(15(20)21,13-10-12(13)14(18)19)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,17H2,(H,18,19)(H,20,21)/t12-,13-,16?/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408692
PNG
(CHEMBL2112584)
Show SMILES NC(CCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO4/c16-15(14(19)20,12-9-11(12)13(17)18)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,17,18)(H,19,20)/t11-,12-,15?/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50455206
PNG
(CHEMBL2311086)
Show SMILES N[C@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20+/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair