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34 similar compounds to monomer 50067261

Compile data set for download or QSAR
Wt: 542.2
BDBM50062878
Wt: 491.5
BDBM50062888
Wt: 457.1
BDBM50062891
Wt: 528.2
BDBM50062892
Wt: 557.2
BDBM50062898
Wt: 529.2
BDBM50062899
Wt: 471.1
BDBM50062901
Wt: 528.2
BDBM50062903
Wt: 557.2
BDBM50062860
Wt: 514.2
BDBM50062863
Wt: 543.2
BDBM50062864
Wt: 528.2
BDBM50062865
Wt: 472.1
BDBM50062867
Wt: 605.3
BDBM50067237
Wt: 663.3
BDBM50067238
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50062878,50062888,50062891,50062892,50062898,50062899,50062901,50062903,50062860,50062863,50062864,50062865,50062867,50067237,50067238   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067238
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H26BrCl2N5O5/c1-4-40-27(38)17-7-5-8-18(13-17)34-28(39)32-14-23(37)35(3)21-11-10-20(30)19(24(21)31)15-41-22-9-6-12-36-25(29)16(2)33-26(22)36/h5-13H,4,14-15H2,1-3H3,(H2,32,34,39)
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n/an/a 2.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50062878
PNG
(CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H23BrCl2N4O3/c1-4-6-18(30)26-11-19(31)28(3)16-9-8-15(24)14(20(16)25)12-32-17-7-5-10-29-21(23)13(2)27-22(17)29/h5,7-10H,4,6,11-12H2,1-3H3,(H,26,30)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067237
PNG
(CHEMBL336209 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-7-4-5-8-19(15)32-26(36)30-13-22(35)33(3)20-11-10-18(28)17(23(20)29)14-37-21-9-6-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 83n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062860
PNG
(CHEMBL132620 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C)CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-13-21(23)30-9-5-6-17(22(30)27-13)33-12-14-15(24)7-8-16(20(14)25)29(4)19(32)10-26-18(31)11-28(2)3/h5-9H,10-12H2,1-4H3,(H,26,31)
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n/an/a 2.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062864
PNG
(CHEMBL336116 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H22BrCl2N5O3/c1-4-25-21(31)26-10-17(30)28(3)15-8-7-14(23)13(18(15)24)11-32-16-6-5-9-29-19(22)12(2)27-20(16)29/h5-9H,4,10-11H2,1-3H3,(H2,25,26,31)
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n/an/a 9n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062903
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CC(NC(C)=O)C(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H21BrCl2N4O3/c1-11-19(22)28-9-5-6-17(20(28)26-11)31-10-14-15(23)7-8-16(18(14)24)27(4)21(30)12(2)25-13(3)29/h5-9,12H,10H2,1-4H3,(H,25,29)
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n/an/a 770n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062898
PNG
(CHEMBL554412 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-4-9-26-22(32)27-11-18(31)29(3)16-8-7-15(24)14(19(16)25)12-33-17-6-5-10-30-20(23)13(2)28-21(17)30/h5-8,10H,4,9,11-12H2,1-3H3,(H2,26,27,32)
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n/an/a 26n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062864
PNG
(CHEMBL336116 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H22BrCl2N5O3/c1-4-25-21(31)26-10-17(30)28(3)15-8-7-14(23)13(18(15)24)11-32-16-6-5-9-29-19(22)12(2)27-20(16)29/h5-9H,4,10-11H2,1-3H3,(H2,25,26,31)
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n/an/a 9n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062899
PNG
(CHEMBL556176 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H20BrCl2N5O3/c1-11-18(21)28-8-4-5-15(19(28)26-11)31-10-12-13(22)6-7-14(17(12)23)27(3)16(29)9-25-20(30)24-2/h4-8H,9-10H2,1-3H3,(H2,24,25,30)
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n/an/a 46n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062867
PNG
(2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyrid...)
Show SMILES CN(C(=O)CN)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C18H17BrCl2N4O2/c1-10-17(19)25-7-3-4-14(18(25)23-10)27-9-11-12(20)5-6-13(16(11)21)24(2)15(26)8-22/h3-7H,8-9,22H2,1-2H3
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n/an/a 380n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062891
PNG
(CHEMBL358234 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C18H16BrCl2N3O2/c1-10-17(19)24-8-4-5-15(18(24)22-10)26-9-12-13(20)6-7-14(16(12)21)23(3)11(2)25/h4-8H,9H2,1-3H3
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n/an/a 54n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062901
PNG
(CHEMBL154625 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCN(C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C19H18BrCl2N3O2/c1-4-24(12(3)26)15-8-7-14(21)13(17(15)22)10-27-16-6-5-9-25-18(20)11(2)23-19(16)25/h5-9H,4,10H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062878
PNG
(CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H23BrCl2N4O3/c1-4-6-18(30)26-11-19(31)28(3)16-9-8-15(24)14(20(16)25)12-32-17-7-5-10-29-21(23)13(2)27-22(17)29/h5,7-10H,4,6,11-12H2,1-3H3,(H,26,30)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062888
PNG
(CHEMBL156847 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(C)=O)c1c(Cl)cc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C18H15BrCl3N3O2/c1-9-17(19)25-6-4-5-14(18(25)23-9)27-8-11-12(20)7-13(21)16(15(11)22)24(3)10(2)26/h4-7H,8H2,1-3H3
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n/an/a 420n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062865
PNG
(CHEMBL543700 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H21BrCl2N4O3/c1-4-17(29)25-10-18(30)27(3)15-8-7-14(23)13(19(15)24)11-31-16-6-5-9-28-20(22)12(2)26-21(16)28/h5-9H,4,10-11H2,1-3H3,(H,25,29)
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n/an/a 19n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062860
PNG
(CHEMBL132620 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C)CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-13-21(23)30-9-5-6-17(22(30)27-13)33-12-14-15(24)7-8-16(20(14)25)29(4)19(32)10-26-18(31)11-28(2)3/h5-9H,10-12H2,1-4H3,(H,26,31)
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n/an/a 2.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062892
PNG
(2-(Acetyl-methyl-amino)-N-[3-(3-bromo-2-methyl-imi...)
Show SMILES CN(CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl)C(C)=O
Show InChI InChI=1S/C21H21BrCl2N4O3/c1-12-20(22)28-9-5-6-17(21(28)25-12)31-11-14-15(23)7-8-16(19(14)24)27(4)18(30)10-26(3)13(2)29/h5-9H,10-11H2,1-4H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro for inhibition of specific binding of [3H]BK (0.06 nM) to bradykinin receptor B2 in guinea pig ileum membrane preparations.


J Med Chem 41: 564-78 (1998)


Article DOI: 10.1021/jm970591c
BindingDB Entry DOI: 10.7270/Q2445N6P
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50062864
PNG
(CHEMBL336116 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H22BrCl2N5O3/c1-4-25-21(31)26-10-17(30)28(3)15-8-7-14(23)13(18(15)24)11-32-16-6-5-9-29-19(22)12(2)27-20(16)29/h5-9H,4,10-11H2,1-3H3,(H2,25,26,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50067237
PNG
(CHEMBL336209 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-7-4-5-8-19(15)32-26(36)30-13-22(35)33(3)20-11-10-18(28)17(23(20)29)14-37-21-9-6-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 150n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50062860
PNG
(CHEMBL132620 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C)CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-13-21(23)30-9-5-6-17(22(30)27-13)33-12-14-15(24)7-8-16(20(14)25)29(4)19(32)10-26-18(31)11-28(2)3/h5-9H,10-12H2,1-4H3,(H,26,31)
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n/an/a 2.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(Homo sapiens (Human))
BDBM50067238
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H26BrCl2N5O5/c1-4-40-27(38)17-7-5-8-18(13-17)34-28(39)32-14-23(37)35(3)21-11-10-20(30)19(24(21)31)15-41-22-9-6-12-36-25(29)16(2)33-26(22)36/h5-13H,4,14-15H2,1-3H3,(H2,32,34,39)
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n/an/a 2.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062878
PNG
(CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H23BrCl2N4O3/c1-4-6-18(30)26-11-19(31)28(3)16-9-8-15(24)14(20(16)25)12-32-17-7-5-10-29-21(23)13(2)27-22(17)29/h5,7-10H,4,6,11-12H2,1-3H3,(H,26,30)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair