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11 similar compounds to monomer 50280563

Compile data set for download or QSAR
Wt: 202.2
BDBM50065205
Wt: 240.3
BDBM50065210
Wt: 164.2
BDBM50065213
Wt: 154.2
BDBM50280559
Wt: 192.2
BDBM50280560
Wt: 178.2
BDBM50280561
Wt: 216.2
BDBM50280562
Wt: 206.2
BDBM50280566
Wt: 178.2
BDBM50280567
Wt: 204.2
BDBM50280573
Wt: 220.3
BDBM50280575

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50065205,50065210,50065213,50280559,50280560,50280561,50280562,50280566,50280567,50280573,50280575   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280567
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Show SMILES CC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C10H14N2O/c1-2-3-6-13-11-10-8-12-5-4-9(10)7-12/h9H,4-8H2,1H3/b11-10+
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n/an/an/an/a 1.90E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280567
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Show SMILES CC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C10H14N2O/c1-2-3-6-13-11-10-8-12-5-4-9(10)7-12/h9H,4-8H2,1H3/b11-10+
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n/an/a 5.81E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280562
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hepta-2,5-diyny...)
Show SMILES CC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H16N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,4,7-11H2,1H3/b14-13+
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n/an/an/an/a 5.05E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/an/an/a 4.70E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/a 8.83E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
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n/an/a 2.18E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/a 6.03E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/a 4.89E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
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n/an/a 2.03E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/a 8.07E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2


J Med Chem 41: 2524-36 (1998)


Article DOI: 10.1021/jm960683m
BindingDB Entry DOI: 10.7270/Q2VD6XKK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50280559
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-ethyl-oxime | C...)
Show SMILES CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C8H14N2O/c1-2-11-9-8-6-10-4-3-7(8)5-10/h7H,2-6H2,1H3/b9-8+
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n/an/an/an/a 8.90E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/a 9.51E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50280567
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Show SMILES CC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C10H14N2O/c1-2-3-6-13-11-10-8-12-5-4-9(10)7-12/h9H,4-8H2,1H3/b11-10+
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n/an/an/an/a 8.80E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280562
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hepta-2,5-diyny...)
Show SMILES CC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H16N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,4,7-11H2,1H3/b14-13+
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n/an/a 5.08E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280566
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-2-ynyl-oxim...)
Show SMILES CCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H18N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h11H,2-3,6-10H2,1H3/b13-12+
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n/an/a 9.64E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280561
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-(1-methyl-prop-...)
Show SMILES CC(O\N=C1/CN2CCC1C2)C#C
Show InChI InChI=1/C10H14N2O/c1-3-8(2)13-11-10-7-12-5-4-9(10)6-12/h1,8-9H,4-7H2,2H3/b11-10+
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n/an/a 3.69E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/a 2.84E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280560
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Show SMILES CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C11H16N2O/c1-2-3-4-7-14-12-11-9-13-6-5-10(11)8-13/h10H,2,5-9H2,1H3/b12-11+
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n/an/a 8.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280567
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Show SMILES CC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C10H14N2O/c1-2-3-6-13-11-10-8-12-5-4-9(10)7-12/h9H,4-8H2,1H3/b11-10+
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n/an/a 1.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/an/an/a 1.64E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280566
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-2-ynyl-oxim...)
Show SMILES CCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H18N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h11H,2-3,6-10H2,1H3/b13-12+
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n/an/a 2.06E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50280560
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Show SMILES CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C11H16N2O/c1-2-3-4-7-14-12-11-9-13-6-5-10(11)8-13/h10H,2,5-9H2,1H3/b12-11+
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n/an/an/an/a 9.60E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/an/an/a 8.40E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/a 1.04E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280560
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Show SMILES CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C11H16N2O/c1-2-3-4-7-14-12-11-9-13-6-5-10(11)8-13/h10H,2,5-9H2,1H3/b12-11+
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n/an/a 4.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280575
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hept-2-ynyl-oxi...)
Show SMILES CCCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H20N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,2-4,7-11H2,1H3/b14-13+
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n/an/a 7.89E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280573
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-5-en-2-ynyl...)
Show SMILES C=CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H16N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h2,11H,1,3,6-10H2/b13-12+
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n/an/a 1.59E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280573
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-5-en-2-ynyl...)
Show SMILES C=CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H16N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h2,11H,1,3,6-10H2/b13-12+
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n/an/a 9.44E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
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n/an/a 2.18E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280561
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-(1-methyl-prop-...)
Show SMILES CC(O\N=C1/CN2CCC1C2)C#C
Show InChI InChI=1/C10H14N2O/c1-3-8(2)13-11-10-7-12-5-4-9(10)6-12/h1,8-9H,4-7H2,2H3/b11-10+
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n/an/a 5.28E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280575
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hept-2-ynyl-oxi...)
Show SMILES CCCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H20N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,2-4,7-11H2,1H3/b14-13+
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n/an/a 9.65E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280561
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-(1-methyl-prop-...)
Show SMILES CC(O\N=C1/CN2CCC1C2)C#C
Show InChI InChI=1/C10H14N2O/c1-3-8(2)13-11-10-7-12-5-4-9(10)6-12/h1,8-9H,4-7H2,2H3/b11-10+
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n/an/a 35n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280573
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-5-en-2-ynyl...)
Show SMILES C=CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H16N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h2,11H,1,3,6-10H2/b13-12+
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280562
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hepta-2,5-diyny...)
Show SMILES CC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H16N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,4,7-11H2,1H3/b14-13+
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n/an/a 39n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280566
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-2-ynyl-oxim...)
Show SMILES CCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H18N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h11H,2-3,6-10H2,1H3/b13-12+
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n/an/a 48n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280567
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Show SMILES CC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C10H14N2O/c1-2-3-6-13-11-10-8-12-5-4-9(10)7-12/h9H,4-8H2,1H3/b11-10+
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/a 3.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
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n/an/an/an/a 5.10E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280559
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-ethyl-oxime | C...)
Show SMILES CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C8H14N2O/c1-2-11-9-8-6-10-4-3-7(8)5-10/h7H,2-6H2,1H3/b9-8+
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065213
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Show SMILES C#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C9H12N2O/c1-2-5-12-10-9-7-11-4-3-8(9)6-11/h1,8H,3-7H2/b10-9+
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n/an/an/an/a 890n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280560
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Show SMILES CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C11H16N2O/c1-2-3-4-7-14-12-11-9-13-6-5-10(11)8-13/h10H,2,5-9H2,1H3/b12-11+
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n/an/an/an/a 5.90E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065205
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Show SMILES C#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C12H14N2O/c1-2-3-4-5-8-15-13-12-10-14-7-6-11(12)9-14/h1,11H,3,6-10H2/b13-12+
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50280562
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hepta-2,5-diyny...)
Show SMILES CC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H16N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,4,7-11H2,1H3/b14-13+
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UniChem

Similars

Article
n/an/a 5.68E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280575
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-hept-2-ynyl-oxi...)
Show SMILES CCCCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C13H20N2O/c1-2-3-4-5-6-9-16-14-13-11-15-8-7-12(13)10-15/h12H,2-4,7-11H2,1H3/b14-13+
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 44n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280560
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Show SMILES CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C11H16N2O/c1-2-3-4-7-14-12-11-9-13-6-5-10(11)8-13/h10H,2,5-9H2,1H3/b12-11+
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50065210
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Show SMILES C#CCC#CCC#CCO\N=C1/CN2CCC1C2
Show InChI InChI=1/C15H16N2O/c1-2-3-4-5-6-7-8-11-18-16-15-13-17-10-9-14(15)12-17/h1,14H,3,6,9-13H2/b16-15+
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.03E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair