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19 similar compounds to monomer 50069423

Compile data set for download or QSAR
Wt: 397.9
BDBM50065465
Wt: 397.9
BDBM50065474
Wt: 509.1
BDBM50069412
Wt: 483.0
BDBM50069413
Wt: 523.1
BDBM50069414
Wt: 537.1
BDBM50069415
Wt: 537.1
BDBM50069416
Wt: 468.0
BDBM50069417
Wt: 411.9
BDBM50069418
Wt: 455.9
BDBM50069419
Wt: 516.1
BDBM50069420
Wt: 502.0
BDBM50069421
Wt: 484.0
BDBM50069422
Wt: 512.0
BDBM50069424
Wt: 484.0
BDBM50069425
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50065465,50065474,50069412,50069413,50069414,50069415,50069416,50069417,50069418,50069419,50069420,50069421,50069422,50069424,50069425   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069414
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(3-pip...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCN4CCCCC4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C31H43ClN4O/c1-25-8-5-10-29-31(25)33-30(24-37-28-13-11-27(32)12-14-28)36(29)21-6-9-26-15-22-35(23-16-26)20-7-19-34-17-3-2-4-18-34/h5,8,10-14,26H,2-4,6-7,9,15-24H2,1H3
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4.5n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells


Bioorg Med Chem Lett 9: 647-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00082-7
BindingDB Entry DOI: 10.7270/Q2QN65ZK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069414
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(3-pip...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCN4CCCCC4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C31H43ClN4O/c1-25-8-5-10-29-31(25)33-30(24-37-28-13-11-27(32)12-14-28)36(29)21-6-9-26-15-22-35(23-16-26)20-7-19-34-17-3-2-4-18-34/h5,8,10-14,26H,2-4,6-7,9,15-24H2,1H3
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4.5n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069415
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(4-pip...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCCN4CCCCC4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C32H45ClN4O/c1-26-9-7-11-30-32(26)34-31(25-38-29-14-12-28(33)13-15-29)37(30)22-8-10-27-16-23-36(24-17-27)21-6-5-20-35-18-3-2-4-19-35/h7,9,11-15,27H,2-6,8,10,16-25H2,1H3
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5.70n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069417
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(3-met...)
Show SMILES CC(C)CCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc23)CC1
Show InChI InChI=1S/C28H38ClN3O/c1-21(2)13-17-31-18-14-23(15-19-31)7-5-16-32-26-8-4-6-22(3)28(26)30-27(32)20-33-25-11-9-24(29)10-12-25/h4,6,8-12,21,23H,5,7,13-20H2,1-3H3
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11n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069421
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-[3-(1-phenet...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCc4ccccc4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C31H36ClN3O/c1-24-7-5-11-29-31(24)33-30(23-36-28-14-12-27(32)13-15-28)35(29)19-6-10-26-17-21-34(22-18-26)20-16-25-8-3-2-4-9-25/h2-5,7-9,11-15,26H,6,10,16-23H2,1H3
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29n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069424
PNG
(4-(4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzo...)
Show SMILES CCOC(=O)CCCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc23)CC1
Show InChI InChI=1S/C29H38ClN3O3/c1-3-35-28(34)10-6-17-32-19-15-23(16-20-32)8-5-18-33-26-9-4-7-22(2)29(26)31-27(33)21-36-25-13-11-24(30)12-14-25/h4,7,9,11-14,23H,3,5-6,8,10,15-21H2,1-2H3
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29n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069412
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(2-pip...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCN4CCCCC4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C30H41ClN4O/c1-24-7-5-9-28-30(24)32-29(23-36-27-12-10-26(31)11-13-27)35(28)18-6-8-25-14-19-34(20-15-25)22-21-33-16-3-2-4-17-33/h5,7,9-13,25H,2-4,6,8,14-23H2,1H3
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37n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069415
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(4-pip...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCCN4CCCCC4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C32H45ClN4O/c1-26-9-7-11-30-32(26)34-31(25-38-29-14-12-28(33)13-15-29)37(30)22-8-10-27-16-23-36(24-17-27)21-6-5-20-35-18-3-2-4-19-35/h7,9,11-15,27H,2-6,8,10,16-25H2,1H3
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52n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069418
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-[3-(1-methyl...)
Show SMILES CN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc23)CC1
Show InChI InChI=1S/C24H30ClN3O/c1-18-5-3-7-22-24(18)26-23(17-29-21-10-8-20(25)9-11-21)28(22)14-4-6-19-12-15-27(2)16-13-19/h3,5,7-11,19H,4,6,12-17H2,1-2H3
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52n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069420
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-{3-[1-(3-phe...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCc4ccccc4)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C32H38ClN3O/c1-25-8-5-13-30-32(25)34-31(24-37-29-16-14-28(33)15-17-29)36(30)21-7-12-27-18-22-35(23-19-27)20-6-11-26-9-3-2-4-10-26/h2-5,8-10,13-17,27H,6-7,11-12,18-24H2,1H3
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57n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069413
PNG
(4-(4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzo...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCC(N)=O)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C27H35ClN4O2/c1-20-5-2-7-24-27(20)30-26(19-34-23-11-9-22(28)10-12-23)32(24)16-3-6-21-13-17-31(18-14-21)15-4-8-25(29)33/h2,5,7,9-12,21H,3-4,6,8,13-19H2,1H3,(H2,29,33)
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88n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065465
PNG
(2-(4-Chloro-phenoxymethyl)-4-methyl-1-(3-piperidin...)
Show SMILES Cc1cccc2n(CCCC3CCCNC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C23H28ClN3O/c1-17-5-2-8-21-23(17)26-22(16-28-20-11-9-19(24)10-12-20)27(21)14-4-7-18-6-3-13-25-15-18/h2,5,8-12,18,25H,3-4,6-7,13-16H2,1H3
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97n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069416
PNG
(1-(4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzo...)
Show SMILES Cc1cccc2n(CCCC3CCN(CC3)C(=O)CCN3CCCCC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C31H41ClN4O2/c1-24-7-5-9-28-31(24)33-29(23-38-27-12-10-26(32)11-13-27)36(28)19-6-8-25-14-21-35(22-15-25)30(37)16-20-34-17-3-2-4-18-34/h5,7,9-13,25H,2-4,6,8,14-23H2,1H3
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260n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065474
PNG
(2-(4-Chloro-phenoxymethyl)-7-methyl-1-(3-piperidin...)
Show SMILES Cc1cccc2nc(COc3ccc(Cl)cc3)n(CCCC3CCCNC3)c12
Show InChI InChI=1S/C23H28ClN3O/c1-17-5-2-8-21-23(17)27(14-4-7-18-6-3-13-25-15-18)22(26-21)16-28-20-11-9-19(24)10-12-20/h2,5,8-12,18,25H,3-4,6-7,13-16H2,1H3
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400n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069425
PNG
((4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzoim...)
Show SMILES CCOC(=O)CN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc23)CC1
Show InChI InChI=1S/C27H34ClN3O3/c1-3-33-26(32)18-30-16-13-21(14-17-30)7-5-15-31-24-8-4-6-20(2)27(24)29-25(31)19-34-23-11-9-22(28)10-12-23/h4,6,8-12,21H,3,5,7,13-19H2,1-2H3
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427n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069422
PNG
(4-(4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzo...)
Show SMILES Cc1cccc2n(CCCC3CCN(CCCC(O)=O)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C27H34ClN3O3/c1-20-5-2-7-24-27(20)29-25(19-34-23-11-9-22(28)10-12-23)31(24)16-3-6-21-13-17-30(18-14-21)15-4-8-26(32)33/h2,5,7,9-12,21H,3-4,6,8,13-19H2,1H3,(H,32,33)
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1.63E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50069419
PNG
((4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzoim...)
Show SMILES Cc1cccc2n(CCCC3CCN(CC(O)=O)CC3)c(COc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C25H30ClN3O3/c1-18-4-2-6-22-25(18)27-23(17-32-21-9-7-20(26)8-10-21)29(22)13-3-5-19-11-14-28(15-12-19)16-24(30)31/h2,4,6-10,19H,3,5,11-17H2,1H3,(H,30,31)
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2.19E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.


Bioorg Med Chem Lett 8: 473-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00048-1
BindingDB Entry DOI: 10.7270/Q2GH9H33
More data for this
Ligand-Target Pair