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3 similar compounds to monomer 50071154

Compile data set for download or QSAR
Wt: 354.3
BDBM50071151
Wt: 278.3
BDBM50071152
Wt: 368.4
BDBM50071166

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50071151,50071152,50071166   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071152
PNG
((2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarb...)
Show SMILES N[C@@]1(C[C@@H](N(CCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18N2O4/c15-14(13(19)20)8-11(12(17)18)16(9-14)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9,15H2,(H,17,18)(H,19,20)/t11-,14-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071166
PNG
((2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(CCC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H24N2O4/c22-21(20(26)27)13-18(19(24)25)23(14-21)12-11-17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-18H,11-14,22H2,(H,24,25)(H,26,27)/t18-,21-/m1/s1
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071166
PNG
((2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(CCC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H24N2O4/c22-21(20(26)27)13-18(19(24)25)23(14-21)12-11-17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-18H,11-14,22H2,(H,24,25)(H,26,27)/t18-,21-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50071152
PNG
((2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarb...)
Show SMILES N[C@@]1(C[C@@H](N(CCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18N2O4/c15-14(13(19)20)8-11(12(17)18)16(9-14)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9,15H2,(H,17,18)(H,19,20)/t11-,14-/m1/s1
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n/an/a 1.66E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a 6.36E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071152
PNG
((2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarb...)
Show SMILES N[C@@]1(C[C@@H](N(CCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18N2O4/c15-14(13(19)20)8-11(12(17)18)16(9-14)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9,15H2,(H,17,18)(H,19,20)/t11-,14-/m1/s1
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n/an/a 6.10E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a 3.73E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071166
PNG
((2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(CCC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H24N2O4/c22-21(20(26)27)13-18(19(24)25)23(14-21)12-11-17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-18H,11-14,22H2,(H,24,25)(H,26,27)/t18-,21-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50071152
PNG
((2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarb...)
Show SMILES N[C@@]1(C[C@@H](N(CCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18N2O4/c15-14(13(19)20)8-11(12(17)18)16(9-14)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9,15H2,(H,17,18)(H,19,20)/t11-,14-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50071166
PNG
((2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(CCC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H24N2O4/c22-21(20(26)27)13-18(19(24)25)23(14-21)12-11-17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-18H,11-14,22H2,(H,24,25)(H,26,27)/t18-,21-/m1/s1
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071152
PNG
((2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarb...)
Show SMILES N[C@@]1(C[C@@H](N(CCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18N2O4/c15-14(13(19)20)8-11(12(17)18)16(9-14)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9,15H2,(H,17,18)(H,19,20)/t11-,14-/m1/s1
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair