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5 similar compounds to monomer 50071178

Compile data set for download or QSAR
Wt: 392.4
BDBM50071171
Purchase
Wt: 348.3
BDBM50071176
Wt: 378.4
BDBM50071179
Wt: 350.4
BDBM50071185
Wt: 406.4
BDBM50071186

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50071171,50071176,50071179,50071185,50071186   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a 950n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/an/an/a 54n/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic M4 receptor expressed in CHO cells assessed as blockade of carbachol-induced inhibition of forskolin-stimulat...


Bioorg Med Chem Lett 18: 2972-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.061
BindingDB Entry DOI: 10.7270/Q2MK6DSM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50071176
PNG
(2-Methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaz...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5ccccc45)Cc3c12
Show InChI InChI=1/C21H20N2O3/c1-12-18(21(24)25-2)19-15-11-23-10-9-13-5-3-4-6-14(13)20(23)26-17(15)8-7-16(19)22-12/h3-8,20,22H,9-11H2,1-2H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a 91n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50071179
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
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n/an/a 3.39E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071176
PNG
(2-Methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaz...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5ccccc45)Cc3c12
Show InChI InChI=1/C21H20N2O3/c1-12-18(21(24)25-2)19-15-11-23-10-9-13-5-3-4-6-14(13)20(23)26-17(15)8-7-16(19)22-12/h3-8,20,22H,9-11H2,1-2H3
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n/an/a 7.12E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071176
PNG
(2-Methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaz...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5ccccc45)Cc3c12
Show InChI InChI=1/C21H20N2O3/c1-12-18(21(24)25-2)19-15-11-23-10-9-13-5-3-4-6-14(13)20(23)26-17(15)8-7-16(19)22-12/h3-8,20,22H,9-11H2,1-2H3
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n/an/a 9.93E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071185
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES COc1cc2CCN3Cc4c(OC3c2cc1OC)ccc1[nH]c(C)cc41
Show InChI InChI=1/C21H22N2O3/c1-12-8-15-16-11-23-7-6-13-9-19(24-2)20(25-3)10-14(13)21(23)26-18(16)5-4-17(15)22-12/h4-5,8-10,21-22H,6-7,11H2,1-3H3
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n/an/a 3.27E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50071186
PNG
(9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OCC)ccc45)Cc3c12
Show InChI InChI=1/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3
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n/an/a 2.57E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071176
PNG
(2-Methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaz...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5ccccc45)Cc3c12
Show InChI InChI=1/C21H20N2O3/c1-12-18(21(24)25-2)19-15-11-23-10-9-13-5-3-4-6-14(13)20(23)26-17(15)8-7-16(19)22-12/h3-8,20,22H,9-11H2,1-2H3
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n/an/a 5.76E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a 7.41E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50071185
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES COc1cc2CCN3Cc4c(OC3c2cc1OC)ccc1[nH]c(C)cc41
Show InChI InChI=1/C21H22N2O3/c1-12-8-15-16-11-23-7-6-13-9-19(24-2)20(25-3)10-14(13)21(23)26-18(16)5-4-17(15)22-12/h4-5,8-10,21-22H,6-7,11H2,1-3H3
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n/an/a 3.26E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071186
PNG
(9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OCC)ccc45)Cc3c12
Show InChI InChI=1/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3
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n/an/a 1.62E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071179
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
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n/an/a 501n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50071176
PNG
(2-Methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaz...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5ccccc45)Cc3c12
Show InChI InChI=1/C21H20N2O3/c1-12-18(21(24)25-2)19-15-11-23-10-9-13-5-3-4-6-14(13)20(23)26-17(15)8-7-16(19)22-12/h3-8,20,22H,9-11H2,1-2H3
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n/an/a 4.66E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50071185
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES COc1cc2CCN3Cc4c(OC3c2cc1OC)ccc1[nH]c(C)cc41
Show InChI InChI=1/C21H22N2O3/c1-12-8-15-16-11-23-7-6-13-9-19(24-2)20(25-3)10-14(13)21(23)26-18(16)5-4-17(15)22-12/h4-5,8-10,21-22H,6-7,11H2,1-3H3
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n/an/a 1.47E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50071186
PNG
(9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OCC)ccc45)Cc3c12
Show InChI InChI=1/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3
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n/an/a 2.63E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50071179
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
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n/an/a 1.31E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a 3.44E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071185
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES COc1cc2CCN3Cc4c(OC3c2cc1OC)ccc1[nH]c(C)cc41
Show InChI InChI=1/C21H22N2O3/c1-12-8-15-16-11-23-7-6-13-9-19(24-2)20(25-3)10-14(13)21(23)26-18(16)5-4-17(15)22-12/h4-5,8-10,21-22H,6-7,11H2,1-3H3
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n/an/a 4.74E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071179
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
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n/an/a 4.09E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071186
PNG
(9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OCC)ccc45)Cc3c12
Show InChI InChI=1/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3
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n/an/a 8.62E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071185
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES COc1cc2CCN3Cc4c(OC3c2cc1OC)ccc1[nH]c(C)cc41
Show InChI InChI=1/C21H22N2O3/c1-12-8-15-16-11-23-7-6-13-9-19(24-2)20(25-3)10-14(13)21(23)26-18(16)5-4-17(15)22-12/h4-5,8-10,21-22H,6-7,11H2,1-3H3
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n/an/a 4.35E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071179
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES COC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
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n/an/a 3.79E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071186
PNG
(9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OCC)ccc45)Cc3c12
Show InChI InChI=1/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3
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n/an/a 4.25E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic M4 receptor expressed in CHO cells assessed as blockade of carbachol-induced inhibition of forskolin-stimulat...


Bioorg Med Chem Lett 18: 2972-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.061
BindingDB Entry DOI: 10.7270/Q2MK6DSM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071171
PNG
(9-Methoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12
Show InChI InChI=1/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
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n/an/a 6.56E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair