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9 similar compounds to monomer 50181434

Wt: 695.7
BDBM50072421
Wt: 665.7
BDBM50072422
Wt: 591.6
BDBM50072425
Wt: 667.7
BDBM50072428
Wt: 563.6
BDBM50072419
Wt: 637.6
BDBM50072420
Wt: 667.7
BDBM50181435
Wt: 695.7
BDBM50181436
Wt: 667.7
BDBM50181433

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50072421,50072422,50072425,50072428,50072419,50072420,50181435,50181436,50181433   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 49n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072425
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C34H33N5O5/c1-23(2)38(26-18-20-27(44-3)21-19-26)30(40)22-37-28-16-10-11-17-29(28)39(25-14-8-5-9-15-25)33(42)31(32(37)41)36-34(43)35-24-12-6-4-7-13-24/h4-21,23,31H,22H2,1-3H3,(H2,35,36,43)
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n/an/a 79n/an/an/an/an/an/a



Glaxo Wellcome

Curated by ChEMBL


Assay Description
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type A receptor stably expressed in CHO-K1 cells


J Med Chem 39: 562-9 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/an/an/a 20n/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 10 nM (Rvb = 7 to 14 pM...


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/an/an/a 51n/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 100 nM (Rvb = 7 to 14 p...


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/an/an/a 120n/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 1000 nM (Rvb = 7 to 14 ...


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 875n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ1 from CCK1R TM2 (unknown origin) containing N2.61T chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 50n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ1 from CCK1R TM3 (unknown origin) containing T3.28V, T3.29S chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ1 from CCK1R TM6 (unknown origin) containing 16.51V, F6.52Y chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
PDB

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n/an/a 233n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ1 from CCK1R TM7 (unknown origin) containing L7.39H chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 40n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK1R TM2 (unknown origin) containing N2.61T chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
PDB

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n/an/a 334n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK1R TM3 (unknown origin) containing T3.28V, T3.29S chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 151n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK1R TM6 (unknown origin) containing 16.51V, F6.52Y chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 153n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK1R TM7 (unknown origin) containing L7.39H chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 26n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ2 from CCK2R TM3 (unknown origin) containing T3.28V, T3.29S chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 36n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ2 from CCK2R TM6 (unknown origin) containing 16.51V, F6.52Y chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 14n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ2 from CCK2R TM7 (unknown origin) containing L7.39H chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 519n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK2R TM2 (unknown origin) containing N2.61T chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 10n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK2R TM3 (unknown origin) containing T3.28V, T3.29S chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 168n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK2R TM6 (unknown origin) containing 16.51V, F6.52Y chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 25n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK2R TM7 (unknown origin) containing L7.39H chimeric mutant expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/an/an/a 90n/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Activity at CCK1R (unknown origin) expressed in CHO cells assessed as stimulation of intracellular calcium responses


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 20n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50181433
PNG
((S)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C39H33N5O6/c1-42(29-20-22-31(50-2)23-21-29)34(45)25-43-32-18-9-10-19-33(32)44(30-16-7-4-8-17-30)38(48)35(37(43)47)41-39(49)40-28-15-11-14-27(24-28)36(46)26-12-5-3-6-13-26/h3-24,35H,25H2,1-2H3,(H2,40,41,49)/t35-/m0/s1
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n/an/a 490n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells


J Med Chem 49: 850-63 (2006)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50181435
PNG
((R)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C39H33N5O6/c1-42(29-20-22-31(50-2)23-21-29)34(45)25-43-32-18-9-10-19-33(32)44(30-16-7-4-8-17-30)38(48)35(37(43)47)41-39(49)40-28-15-11-14-27(24-28)36(46)26-12-5-3-6-13-26/h3-24,35H,25H2,1-2H3,(H2,40,41,49)/t35-/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells


J Med Chem 49: 850-63 (2006)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50181436
PNG
((R)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C41H37N5O6/c1-27(2)45(32-21-23-33(52-3)24-22-32)36(47)26-44-34-19-10-11-20-35(34)46(31-17-8-5-9-18-31)40(50)37(39(44)49)43-41(51)42-30-16-12-15-29(25-30)38(48)28-13-6-4-7-14-28/h4-25,27,37H,26H2,1-3H3,(H2,42,43,51)/t37-/m1/s1
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n/an/a 710n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells


J Med Chem 49: 850-63 (2006)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 390n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072420
PNG
(2-{3-[3-(3-Benzoyl-phenyl)-ureido]-2,4-dioxo-5-phe...)
Show SMILES CN(C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O)c1ccccc1
Show InChI InChI=1S/C38H31N5O5/c1-41(29-18-7-3-8-19-29)33(44)25-42-31-22-11-12-23-32(31)43(30-20-9-4-10-21-30)37(47)34(36(42)46)40-38(48)39-28-17-13-16-27(24-28)35(45)26-14-5-2-6-15-26/h2-24,34H,25H2,1H3,(H2,39,40,48)
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n/an/a 290n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072425
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C34H33N5O5/c1-23(2)38(26-18-20-27(44-3)21-19-26)30(40)22-37-28-16-10-11-17-29(28)39(25-14-8-5-9-15-25)33(42)31(32(37)41)36-34(43)35-24-12-6-4-7-13-24/h4-21,23,31H,22H2,1-3H3,(H2,35,36,43)
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n/an/a 50n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072421
PNG
(2-{3-[3-(3-Benzoyl-phenyl)-ureido]-2,4-dioxo-5-phe...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C41H37N5O6/c1-27(2)45(32-21-23-33(52-3)24-22-32)36(47)26-44-34-19-10-11-20-35(34)46(31-17-8-5-9-18-31)40(50)37(39(44)49)43-41(51)42-30-16-12-15-29(25-30)38(48)28-13-6-4-7-14-28/h4-25,27,37H,26H2,1-3H3,(H2,42,43,51)
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n/an/a 80n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072428
PNG
(2-{3-[3-(3-Benzoyl-phenyl)-ureido]-2,4-dioxo-5-phe...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C39H33N5O6/c1-42(29-20-22-31(50-2)23-21-29)34(45)25-43-32-18-9-10-19-33(32)44(30-16-7-4-8-17-30)38(48)35(37(43)47)41-39(49)40-28-15-11-14-27(24-28)36(46)26-12-5-3-6-13-26/h3-24,35H,25H2,1-2H3,(H2,40,41,49)
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n/an/a 350n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50072422
PNG
(2-{3-[3-(3-Benzoyl-phenyl)-ureido]-2,4-dioxo-5-phe...)
Show SMILES CC(C)N(C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O)c1ccccc1
Show InChI InChI=1S/C40H35N5O5/c1-27(2)44(31-19-8-4-9-20-31)35(46)26-43-33-23-12-13-24-34(33)45(32-21-10-5-11-22-32)39(49)36(38(43)48)42-40(50)41-30-18-14-17-29(25-30)37(47)28-15-6-3-7-16-28/h3-25,27,36H,26H2,1-2H3,(H2,41,42,50)
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n/an/a 160n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072425
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C34H33N5O5/c1-23(2)38(26-18-20-27(44-3)21-19-26)30(40)22-37-28-16-10-11-17-29(28)39(25-14-8-5-9-15-25)33(42)31(32(37)41)36-34(43)35-24-12-6-4-7-13-24/h4-21,23,31H,22H2,1-3H3,(H2,35,36,43)
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n/an/a 50n/an/an/an/an/an/a



Glaxo Wellcome

Curated by ChEMBL


Assay Description
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells


J Med Chem 39: 562-9 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50072419
PNG
(2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C32H29N5O5/c1-35(23-17-19-25(42-2)20-18-23)28(38)21-36-26-15-9-10-16-27(26)37(24-13-7-4-8-14-24)31(40)29(30(36)39)34-32(41)33-22-11-5-3-6-12-22/h3-20,29H,21H2,1-2H3,(H2,33,34,41)
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n/an/a 46n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK from CCK1R (unknown origin) expressed in CHO cells


Bioorg Med Chem Lett 25: 1849-55 (2015)

More data for this
Ligand-Target Pair