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17 similar compounds to monomer 50095669

Compile data set for download or QSAR
Wt: 384.5
BDBM50079714
Wt: 420.5
BDBM50095654
Wt: 434.5
BDBM50095658
Wt: 420.5
BDBM50095668
Wt: 412.6
BDBM50095672
Wt: 384.5
BDBM50095684
Wt: 400.5
BDBM50095686
Wt: 402.5
BDBM50095688
Wt: 398.5
BDBM50095689
Wt: 448.5
BDBM50095690
Wt: 366.4
BDBM50129388
Wt: 352.4
BDBM50129393
Wt: 338.3
BDBM50129395
Wt: 338.3
BDBM50129404
Wt: 382.5
BDBM50218046
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50079714,50095654,50095658,50095668,50095672,50095684,50095686,50095688,50095689,50095690,50129388,50129393,50129395,50129404,50218046   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50129404
PNG
((R)-1-(4-Amino-piperidin-1-yl)-2-((R)-3,3-difluoro...)
Show SMILES NC1CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-10-7-15(21)8-11-22/h1-5,14-15,24H,6-12,21H2/t14-,18+/m1/s1
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3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50079714
PNG
((R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27)/t24-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for human cloned Muscarinic M3 receptors


Bioorg Med Chem Lett 9: 2037-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00327-3
BindingDB Entry DOI: 10.7270/Q2K64H88
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50079714
PNG
((R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27)/t24-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50129393
PNG
((R)-1-(4-Amino-4-methyl-piperidin-1-yl)-2-((R)-3,3...)
Show SMILES CC1(N)CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C19H26F2N2O2/c1-17(22)9-11-23(12-10-17)16(24)19(25,14-5-3-2-4-6-14)15-7-8-18(20,21)13-15/h2-6,15,25H,7-13,22H2,1H3/t15-,19+/m1/s1
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4.70n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50129404
PNG
((R)-1-(4-Amino-piperidin-1-yl)-2-((R)-3,3-difluoro...)
Show SMILES NC1CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-10-7-15(21)8-11-22/h1-5,14-15,24H,6-12,21H2/t14-,18+/m1/s1
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5.10n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095654
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24+/m1/s1
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6.20n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50129393
PNG
((R)-1-(4-Amino-4-methyl-piperidin-1-yl)-2-((R)-3,3...)
Show SMILES CC1(N)CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C19H26F2N2O2/c1-17(22)9-11-23(12-10-17)16(24)19(25,14-5-3-2-4-6-14)15-7-8-18(20,21)13-15/h2-6,15,25H,7-13,22H2,1H3/t15-,19+/m1/s1
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8.30n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095688
PNG
(2-(3-Fluoro-cyclopentyl)-2-hydroxy-N-[1-(4-methyl-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@@H](F)C1)c1ccccc1
Show InChI InChI=1S/C24H35FN2O2/c1-18(2)7-6-14-27-15-12-22(13-16-27)26-23(28)24(29,19-8-4-3-5-9-19)20-10-11-21(25)17-20/h3-5,7-9,20-22,29H,6,10-17H2,1-2H3,(H,26,28)/t20-,21+,24-/m0/s1
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11n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095672
PNG
(CHEMBL148129 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N2O2/c29-25(26(30,23-14-8-9-15-23)22-12-6-3-7-13-22)27-24-16-18-28(19-17-24)20-21-10-4-1-2-5-11-21/h3,6-7,12-13,21,23-24,30H,1-2,4-5,8-11,14-20H2,(H,27,29)
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12n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095668
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24-/m0/s1
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16n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095689
PNG
(CHEMBL149769 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N2O2/c28-24(25(29,22-13-7-8-14-22)21-11-5-2-6-12-21)26-23-15-17-27(18-16-23)19-20-9-3-1-4-10-20/h2,5-6,11-12,20,22-23,29H,1,3-4,7-10,13-19H2,(H,26,28)
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17n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095686
PNG
(2-Hydroxy-2-(3-hydroxy-cyclopentyl)-N-[1-(4-methyl...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@H](O)C1)c1ccccc1
Show InChI InChI=1S/C24H36N2O3/c1-18(2)7-6-14-26-15-12-21(13-16-26)25-23(28)24(29,19-8-4-3-5-9-19)20-10-11-22(27)17-20/h3-5,7-9,20-22,27,29H,6,10-17H2,1-2H3,(H,25,28)/t20-,22-,24-/m0/s1
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18n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095658
PNG
(CHEMBL146359 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36F2N2O2/c26-24(27)14-11-21(17-24)25(31,20-9-5-2-6-10-20)23(30)28-22-12-15-29(16-13-22)18-19-7-3-1-4-8-19/h2,5-6,9-10,19,21-22,31H,1,3-4,7-8,11-18H2,(H,28,30)/t21-,25+/m1/s1
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18n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50079714
PNG
((R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27)/t24-/m0/s1
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19n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095654
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24+/m1/s1
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22n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095690
PNG
(CHEMBL358289 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38F2N2O2/c27-25(28)15-12-22(18-25)26(32,21-10-6-3-7-11-21)24(31)29-23-13-16-30(17-14-23)19-20-8-4-1-2-5-9-20/h3,6-7,10-11,20,22-23,32H,1-2,4-5,8-9,12-19H2,(H,29,31)/t22-,26+/m1/s1
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28n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [3H]-NMS was determined by receptor binding assay using membranes from chinese hamster ovary (CHO) cells expressing clo...


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50218046
PNG
((R)-2-cyclopentyl-2-hydroxy-N-((1S,5R,6s)-3-(4-met...)
Show SMILES CC(C)=CCCN1C[C@H]2[C@@H](C1)[C@@H]2NC(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H34N2O2/c1-17(2)9-8-14-26-15-20-21(16-26)22(20)25-23(27)24(28,19-12-6-7-13-19)18-10-4-3-5-11-18/h3-5,9-11,19-22,28H,6-8,12-16H2,1-2H3,(H,25,27)/t20-,21+,22+,24?
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33n/an/an/an/an/an/an/an/a



Ranbaxy Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland


Bioorg Med Chem Lett 17: 5256-60 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.081
BindingDB Entry DOI: 10.7270/Q27D2W0F
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50129388
PNG
((R)-N-(4-Aminomethyl-cyclohexyl)-2-((R)-3,3-difluo...)
Show SMILES NCC1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C20H28F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-5,14,16-17,26H,6-13,23H2,(H,24,25)/t14?,16-,17?,20+/m1/s1
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55n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095668
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24-/m0/s1
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57n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095688
PNG
(2-(3-Fluoro-cyclopentyl)-2-hydroxy-N-[1-(4-methyl-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@@H](F)C1)c1ccccc1
Show InChI InChI=1S/C24H35FN2O2/c1-18(2)7-6-14-27-15-12-22(13-16-27)26-23(28)24(29,19-8-4-3-5-9-19)20-10-11-21(25)17-20/h3-5,7-9,20-22,29H,6,10-17H2,1-2H3,(H,26,28)/t20-,21+,24-/m0/s1
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61n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095686
PNG
(2-Hydroxy-2-(3-hydroxy-cyclopentyl)-N-[1-(4-methyl...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@H](O)C1)c1ccccc1
Show InChI InChI=1S/C24H36N2O3/c1-18(2)7-6-14-26-15-12-21(13-16-26)25-23(28)24(29,19-8-4-3-5-9-19)20-10-11-22(27)17-20/h3-5,7-9,20-22,27,29H,6,10-17H2,1-2H3,(H,25,28)/t20-,22-,24-/m0/s1
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88n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50129388
PNG
((R)-N-(4-Aminomethyl-cyclohexyl)-2-((R)-3,3-difluo...)
Show SMILES NCC1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C20H28F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-5,14,16-17,26H,6-13,23H2,(H,24,25)/t14?,16-,17?,20+/m1/s1
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100n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095658
PNG
(CHEMBL146359 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36F2N2O2/c26-24(27)14-11-21(17-24)25(31,20-9-5-2-6-10-20)23(30)28-22-12-15-29(16-13-22)18-19-7-3-1-4-8-19/h2,5-6,9-10,19,21-22,31H,1,3-4,7-8,11-18H2,(H,28,30)/t21-,25+/m1/s1
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140n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095690
PNG
(CHEMBL358289 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38F2N2O2/c27-25(28)15-12-22(18-25)26(32,21-10-6-3-7-11-21)24(31)29-23-13-16-30(17-14-23)19-20-8-4-1-2-5-9-20/h3,6-7,10-11,20,22-23,32H,1-2,4-5,8-9,12-19H2,(H,29,31)/t22-,26+/m1/s1
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170n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095689
PNG
(CHEMBL149769 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N2O2/c28-24(25(29,22-13-7-8-14-22)21-11-5-2-6-12-21)26-23-15-17-27(18-16-23)19-20-9-3-1-4-10-20/h2,5-6,11-12,20,22-23,29H,1,3-4,7-10,13-19H2,(H,26,28)
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200n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095672
PNG
(CHEMBL148129 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N2O2/c29-25(26(30,23-14-8-9-15-23)22-12-6-3-7-13-22)27-24-16-18-28(19-17-24)20-21-10-4-1-2-5-11-21/h3,6-7,12-13,21,23-24,30H,1-2,4-5,8-11,14-20H2,(H,27,29)
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200n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50129404
PNG
((R)-1-(4-Amino-piperidin-1-yl)-2-((R)-3,3-difluoro...)
Show SMILES NC1CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-10-7-15(21)8-11-22/h1-5,14-15,24H,6-12,21H2/t14-,18+/m1/s1
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240n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50095684
PNG
(2-Cyclopentyl-N-(1-cyclopentylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c27-23(24(28,21-12-6-7-13-21)20-10-2-1-3-11-20)25-22-14-16-26(17-15-22)18-19-8-4-5-9-19/h1-3,10-11,19,21-22,28H,4-9,12-18H2,(H,25,27)
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270n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50129395
PNG
((R)-2-((R)-3,3-Difluoro-cyclopentyl)-2-hydroxy-2-p...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-15-7-10-21-11-8-15/h1-5,14-15,21,24H,6-12H2,(H,22,23)/t14-,18+/m1/s1
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310n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50129395
PNG
((R)-2-((R)-3,3-Difluoro-cyclopentyl)-2-hydroxy-2-p...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-15-7-10-21-11-8-15/h1-5,14-15,21,24H,6-12H2,(H,22,23)/t14-,18+/m1/s1
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320n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50079714
PNG
((R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27)/t24-/m0/s1
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490n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50129393
PNG
((R)-1-(4-Amino-4-methyl-piperidin-1-yl)-2-((R)-3,3...)
Show SMILES CC1(N)CCN(CC1)C(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C19H26F2N2O2/c1-17(22)9-11-23(12-10-17)16(24)19(25,14-5-3-2-4-6-14)15-7-8-18(20,21)13-15/h2-6,15,25H,7-13,22H2,1H3/t15-,19+/m1/s1
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640n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50218046
PNG
((R)-2-cyclopentyl-2-hydroxy-N-((1S,5R,6s)-3-(4-met...)
Show SMILES CC(C)=CCCN1C[C@H]2[C@@H](C1)[C@@H]2NC(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C24H34N2O2/c1-17(2)9-8-14-26-15-20-21(16-26)22(20)25-23(27)24(28,19-12-6-7-13-19)18-10-4-3-5-11-18/h3-5,9-11,19-22,28H,6-8,12-16H2,1-2H3,(H,25,27)/t20-,21+,22+,24?
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1.37E+3n/an/an/an/an/an/an/an/a



Ranbaxy Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart


Bioorg Med Chem Lett 17: 5256-60 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.081
BindingDB Entry DOI: 10.7270/Q27D2W0F
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095668
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24-/m0/s1
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1.40E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095654
PNG
(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(4-met...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C24H34F2N2O2/c1-18(2)7-6-14-28-15-11-21(12-16-28)27-22(29)24(30,19-8-4-3-5-9-19)20-10-13-23(25,26)17-20/h3-5,7-9,20-21,30H,6,10-17H2,1-2H3,(H,27,29)/t20-,24+/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095686
PNG
(2-Hydroxy-2-(3-hydroxy-cyclopentyl)-N-[1-(4-methyl...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@H](O)C1)c1ccccc1
Show InChI InChI=1S/C24H36N2O3/c1-18(2)7-6-14-26-15-12-21(13-16-26)25-23(28)24(29,19-8-4-3-5-9-19)20-10-11-22(27)17-20/h3-5,7-9,20-22,27,29H,6,10-17H2,1-2H3,(H,25,28)/t20-,22-,24-/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095688
PNG
(2-(3-Fluoro-cyclopentyl)-2-hydroxy-N-[1-(4-methyl-...)
Show SMILES CC(C)=CCCN1CCC(CC1)NC(=O)[C@@](O)([C@H]1CC[C@@H](F)C1)c1ccccc1
Show InChI InChI=1S/C24H35FN2O2/c1-18(2)7-6-14-27-15-12-22(13-16-27)26-23(28)24(29,19-8-4-3-5-9-19)20-10-11-21(25)17-20/h3-5,7-9,20-22,29H,6,10-17H2,1-2H3,(H,26,28)/t20-,21+,24-/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095672
PNG
(CHEMBL148129 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N2O2/c29-25(26(30,23-14-8-9-15-23)22-12-6-3-7-13-22)27-24-16-18-28(19-17-24)20-21-10-4-1-2-5-11-21/h3,6-7,12-13,21,23-24,30H,1-2,4-5,8-11,14-20H2,(H,27,29)
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3.10E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095689
PNG
(CHEMBL149769 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N2O2/c28-24(25(29,22-13-7-8-14-22)21-11-5-2-6-12-21)26-23-15-17-27(18-16-23)19-20-9-3-1-4-10-20/h2,5-6,11-12,20,22-23,29H,1,3-4,7-10,13-19H2,(H,26,28)
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3.30E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50095684
PNG
(2-Cyclopentyl-N-(1-cyclopentylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c27-23(24(28,21-12-6-7-13-21)20-10-2-1-3-11-20)25-22-14-16-26(17-15-22)18-19-8-4-5-9-19/h1-3,10-11,19,21-22,28H,4-9,12-18H2,(H,25,27)
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4.30E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50129388
PNG
((R)-N-(4-Aminomethyl-cyclohexyl)-2-((R)-3,3-difluo...)
Show SMILES NCC1CCC(CC1)NC(=O)[C@@](O)([C@@H]1CCC(F)(F)C1)c1ccccc1
Show InChI InChI=1S/C20H28F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-5,14,16-17,26H,6-13,23H2,(H,24,25)/t14?,16-,17?,20+/m1/s1
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6.80E+3n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095684
PNG
(2-Cyclopentyl-N-(1-cyclopentylmethyl-piperidin-4-y...)
Show SMILES OC(C1CCCC1)(C(=O)NC1CCN(CC2CCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N2O2/c27-23(24(28,21-12-6-7-13-21)20-10-2-1-3-11-20)25-22-14-16-26(17-15-22)18-19-8-4-5-9-19/h1-3,10-11,19,21-22,28H,4-9,12-18H2,(H,25,27)
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1.40E+4n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50129395
PNG
((R)-2-((R)-3,3-Difluoro-cyclopentyl)-2-hydroxy-2-p...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C18H24F2N2O2/c19-17(20)9-6-14(12-17)18(24,13-4-2-1-3-5-13)16(23)22-15-7-10-21-11-8-15/h1-5,14-15,21,24H,6-12H2,(H,22,23)/t14-,18+/m1/s1
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1.50E+4n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells


Bioorg Med Chem Lett 13: 2167-72 (2003)


Article DOI: 10.1016/s0960-894x(03)00350-0
BindingDB Entry DOI: 10.7270/Q29G5M68
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095690
PNG
(CHEMBL358289 | N-(1-Cycloheptylmethyl-piperidin-4-...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38F2N2O2/c27-25(28)15-12-22(18-25)26(32,21-10-6-3-7-11-21)24(31)29-23-13-16-30(17-14-23)19-20-8-4-1-2-5-9-20/h3,6-7,10-11,20,22-23,32H,1-2,4-5,8-9,12-19H2,(H,29,31)/t22-,26+/m1/s1
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1.70E+4n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50095658
PNG
(CHEMBL146359 | N-(1-Cyclohexylmethyl-piperidin-4-y...)
Show SMILES O[C@@]([C@@H]1CCC(F)(F)C1)(C(=O)NC1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36F2N2O2/c26-24(27)14-11-21(17-24)25(31,20-9-5-2-6-10-20)23(30)28-22-12-15-29(16-13-22)18-19-7-3-1-4-8-19/h2,5-6,9-10,19,21-22,31H,1,3-4,7-8,11-18H2,(H,28,30)/t21-,25+/m1/s1
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2.10E+4n/an/an/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells


J Med Chem 43: 5017-29 (2001)


Article DOI: 10.1021/jm0003135
BindingDB Entry DOI: 10.7270/Q2HM57P7
More data for this
Ligand-Target Pair