BindingDB logo
myBDB logout

7 similar compounds to monomer 50080064

Compile data set for download or QSAR
Wt: 366.2
BDBM50080058
Wt: 324.2
BDBM50080059
Wt: 298.1
BDBM50080063
Wt: 338.2
BDBM50080066
Wt: 352.2
BDBM50080067
Wt: 346.2
BDBM50080068
Wt: 338.2
BDBM50080069

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50080058,50080059,50080063,50080066,50080067,50080068,50080069   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080058
PNG
(1-[(Z)-2-Cyclooctyloxy-2-(2,4-dichloro-phenyl)-vin...)
Show SMILES Clc1ccc(\C(OC2CCCCCCC2)=C\n2cncn2)c(Cl)c1
Show InChI InChI=1S/C18H21Cl2N3O/c19-14-8-9-16(17(20)10-14)18(11-23-13-21-12-22-23)24-15-6-4-2-1-3-5-7-15/h8-13,15H,1-7H2/b18-11-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.21E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080059
PNG
(1-[(Z)-2-Cyclopentyloxy-2-(2,4-dichloro-phenyl)-vi...)
Show SMILES Clc1ccc(\C(OC2CCCC2)=C\n2cncn2)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N3O/c16-11-5-6-13(14(17)7-11)15(8-20-10-18-9-19-20)21-12-3-1-2-4-12/h5-10,12H,1-4H2/b15-8-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.55E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080063
PNG
(1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]...)
Show SMILES CC(C)O\C(=C/n1cncn1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O/c1-9(2)19-13(6-18-8-16-7-17-18)11-4-3-10(14)5-12(11)15/h3-9H,1-2H3/b13-6-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.15E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080063
PNG
(1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]...)
Show SMILES CC(C)O\C(=C/n1cncn1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O/c1-9(2)19-13(6-18-8-16-7-17-18)11-4-3-10(14)5-12(11)15/h3-9H,1-2H3/b13-6-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGlu2 expressed in CHO cells assessed as inibition of (1S,3R)-ACPD-stimulated GTPgammaS binding


Bioorg Med Chem Lett 17: 6811-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.10.026
BindingDB Entry DOI: 10.7270/Q2R78DZD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080067
PNG
(1-[(Z)-2-Cycloheptyloxy-2-(2,4-dichloro-phenyl)-vi...)
Show SMILES Clc1ccc(\C(OC2CCCCCC2)=C\n2cncn2)c(Cl)c1
Show InChI InChI=1S/C17H19Cl2N3O/c18-13-7-8-15(16(19)9-13)17(10-22-12-20-11-21-22)23-14-5-3-1-2-4-6-14/h7-12,14H,1-6H2/b17-10-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 470n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080068
PNG
(1-[(Z)-2-Benzyloxy-2-(2,6-dichloro-phenyl)-vinyl]-...)
Show SMILES Clc1cccc(Cl)c1\C(OCc1ccccc1)=C\n1cncn1
Show InChI InChI=1S/C17H13Cl2N3O/c18-14-7-4-8-15(19)17(14)16(9-22-12-20-11-21-22)23-10-13-5-2-1-3-6-13/h1-9,11-12H,10H2/b16-9-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080069
PNG
(1-[(Z)-2-Cyclohexyloxy-2-(2,6-dichloro-phenyl)-vin...)
Show SMILES Clc1cccc(Cl)c1\C(OC1CCCCC1)=C\n1cncn1
Show InChI InChI=1S/C16H17Cl2N3O/c17-13-7-4-8-14(18)16(13)15(9-21-11-19-10-20-21)22-12-5-2-1-3-6-12/h4,7-12H,1-3,5-6H2/b15-9-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 580n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50080066
PNG
(1-[(Z)-2-Cyclohexyloxy-2-(2,4-dichloro-phenyl)-vin...)
Show SMILES Clc1ccc(\C(OC2CCCCC2)=C\n2cncn2)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N3O/c17-12-6-7-14(15(18)8-12)16(9-21-11-19-10-20-21)22-13-4-2-1-3-5-13/h6-11,13H,1-5H2/b16-9-
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.05E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells


Bioorg Med Chem Lett 9: 2173-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00346-7
BindingDB Entry DOI: 10.7270/Q27S7MZC
More data for this
Ligand-Target Pair