BindingDB logo
myBDB logout

14 similar compounds to monomer 50090641

Compile data set for download or QSAR
Wt: 393.3
BDBM50081227
Wt: 421.3
BDBM50081229
Wt: 459.4
BDBM50081233
Wt: 391.3
BDBM50081234
Wt: 405.3
BDBM50081235
Wt: 473.4
BDBM50081238
Wt: 421.3
BDBM50090636
Wt: 405.3
BDBM50090637
Wt: 407.3
BDBM50090638
Wt: 407.3
BDBM50090639
Wt: 421.3
BDBM50090642
Wt: 447.4
BDBM50100978
Wt: 447.4
BDBM50100979
Wt: 382.3
BDBM50366477
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50081227,50081229,50081233,50081234,50081235,50081238,50090636,50090637,50090638,50090639,50090642,50100978,50100979,50366477   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Squalene synthetase


(Rattus norvegicus)
BDBM50366477
PNG
(CHEMBL69330)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O
Show InChI InChI=1/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
2.60E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against microsomal Squalene synthase


J Med Chem 34: 1912-4 (1991)

Checked by Author
Article DOI: 10.1021/jm00110a024
BindingDB Entry DOI: 10.7270/Q2S75GXZ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50366477
PNG
(CHEMBL69330)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O
Show InChI InChI=1/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

MMDB
PDB
PubMed
n/an/an/a 2n/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Binding affinity to FTase (unknown origin)


Medchemcomm 4: 476-492 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081227
PNG
(10-ethyl-2,6-dimethyl-(6E,10E)-2,6,10-dodecatriene...)
Show SMILES CC\C(CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C16H30O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h8,10,12H,5-7,9,11,13H2,1-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 215n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081229
PNG
(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(=C\COP([O-])(=O)OP([O-])([O-])=O)C(C)(C)C
Show InChI InChI=1S/C18H34O7P2/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-24-27(22,23)25-26(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,17-13-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081233
PNG
(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C21H36O7P2/c1-6-21(16-17-27-30(25,26)28-29(22,23)24)15-9-14-20(5)13-8-12-19(4)11-7-10-18(2)3/h6,10,12,14,16H,1,7-9,11,13,15,17H2,2-5H3,(H,25,26)(H2,22,23,24)/p-3/b19-12+,20-14+,21-16+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 715n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081234
PNG
(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C16H28O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h5,8,10,12H,1,6-7,9,11,13H2,2-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 173n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081235
PNG
(3-substituted farnesyl diphosphate analogue | 4-[(...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(CC=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C17H30O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081234
PNG
(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C16H28O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h5,8,10,12H,1,6-7,9,11,13H2,2-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081229
PNG
(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(=C\COP([O-])(=O)OP([O-])([O-])=O)C(C)(C)C
Show InChI InChI=1S/C18H34O7P2/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-24-27(22,23)25-26(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,17-13-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081235
PNG
(3-substituted farnesyl diphosphate analogue | 4-[(...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(CC=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C17H30O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 189n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081233
PNG
(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C21H36O7P2/c1-6-21(16-17-27-30(25,26)28-29(22,23)24)15-9-14-20(5)13-8-12-19(4)11-7-10-18(2)3/h6,10,12,14,16H,1,7-9,11,13,15,17H2,2-5H3,(H,25,26)(H2,22,23,24)/p-3/b19-12+,20-14+,21-16+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.05E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081227
PNG
(10-ethyl-2,6-dimethyl-(6E,10E)-2,6,10-dodecatriene...)
Show SMILES CC\C(CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C16H30O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h8,10,12H,5-7,9,11,13H2,1-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081238
PNG
(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(CC=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C22H38O7P2/c1-6-10-22(17-18-28-31(26,27)29-30(23,24)25)16-9-15-21(5)14-8-13-20(4)12-7-11-19(2)3/h6,11,13,15,17H,1,7-10,12,14,16,18H2,2-5H3,(H,26,27)(H2,23,24,25)/p-3/b20-13+,21-15+,22-17+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.38E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081238
PNG
(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(CC=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C22H38O7P2/c1-6-10-22(17-18-28-31(26,27)29-30(23,24)25)16-9-15-21(5)14-8-13-20(4)12-7-11-19(2)3/h6,11,13,15,17H,1,7-10,12,14,16,18H2,2-5H3,(H,26,27)(H2,23,24,25)/p-3/b20-13+,21-15+,22-17+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 453n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay


J Med Chem 42: 3800-8 (1999)


Article DOI: 10.1021/jm9902786
BindingDB Entry DOI: 10.7270/Q2Z89D3S
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090637
PNG
((2Z,6E)-7,11-dimethyl-3-(prop-1-en-2-yl)dodeca-2,6...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(=C\COP([O-])(=O)OP([O-])([O-])=O)C(C)=C
Show InChI InChI=1S/C17H30O7P2/c1-14(2)8-6-9-16(5)10-7-11-17(15(3)4)12-13-23-26(21,22)24-25(18,19)20/h8,10,12H,3,6-7,9,11,13H2,1-2,4-5H3,(H,21,22)(H2,18,19,20)/p-3/b16-10+,17-12-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090638
PNG
((2E,6E)-7,11-dimethyl-3-propyldodeca-2,6,10-trien-...)
Show SMILES CCC\C(CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C17H32O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h9,11,13H,5-8,10,12,14H2,1-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 453n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090639
PNG
((2Z,6E)-7,11-dimethyl-3-(propan-2-yl)dodeca-2,6,10...)
Show SMILES CC(C)C(\CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C17H32O7P2/c1-14(2)8-6-9-16(5)10-7-11-17(15(3)4)12-13-23-26(21,22)24-25(18,19)20/h8,10,12,15H,6-7,9,11,13H2,1-5H3,(H,21,22)(H2,18,19,20)/p-3/b16-10+,17-12-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081229
PNG
(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(=C\COP([O-])(=O)OP([O-])([O-])=O)C(C)(C)C
Show InChI InChI=1S/C18H34O7P2/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-24-27(22,23)25-26(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,17-13-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090636
PNG
((2Z,6E)-3-(butan-2-yl)-7,11-dimethyldodeca-2,6,10-...)
Show SMILES CCC(C)C(\CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1/C18H34O7P2/c1-6-17(5)18(12-8-11-16(4)10-7-9-15(2)3)13-14-24-27(22,23)25-26(19,20)21/h9,11,13,17H,6-8,10,12,14H2,1-5H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,18-13-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 102n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081235
PNG
(3-substituted farnesyl diphosphate analogue | 4-[(...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(CC=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C17H30O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 119n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50081234
PNG
(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C=C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C16H28O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h5,8,10,12H,1,6-7,9,11,13H2,2-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 173n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090642
PNG
((2Z,6E)-7,11-dimethyl-3-(2-methylpropyl)dodeca-2,6...)
Show SMILES CC(C)C\C(CC\C=C(/C)CCC=C(C)C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C18H34O7P2/c1-15(2)8-6-9-17(5)10-7-11-18(14-16(3)4)12-13-24-27(22,23)25-26(19,20)21/h8,10,12,16H,6-7,9,11,13-14H2,1-5H3,(H,22,23)(H2,19,20,21)/p-3/b17-10+,18-12-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50366477
PNG
(CHEMBL69330)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O
Show InChI InChI=1/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
n/an/an/a 75n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50100979
PNG
(Phosphoric acid di-((2Z,6E,10E)-3,7,11,15-tetramet...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/p-3/b18-11+,19-13+,20-15-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEBI
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.


Bioorg Med Chem Lett 11: 1605-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00292-x
BindingDB Entry DOI: 10.7270/Q26W9BM2
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50100978
PNG
(Phosphoric acid di-((2E,6Z,10E)-3,7,11,15-tetramet...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C/CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/p-3/b18-11+,19-13-,20-15+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEBI
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.


Bioorg Med Chem Lett 11: 1605-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00292-x
BindingDB Entry DOI: 10.7270/Q26W9BM2
More data for this
Ligand-Target Pair