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11 similar compounds to monomer 50083190

Compile data set for download or QSAR
Wt: 286.3
BDBM50083195
Wt: 304.7
BDBM50083197
Wt: 286.3
BDBM50083198
Wt: 319.7
BDBM50083188
Wt: 304.7
BDBM50083191
Wt: 270.3
BDBM50083192
Wt: 362.8
BDBM50105640
Wt: 348.8
BDBM50105649
Wt: 348.8
BDBM50105650
Wt: 292.7
BDBM50105630
Wt: 332.8
BDBM50413524

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50083195,50083197,50083198,50083188,50083191,50083192,50105640,50105649,50105650,50105630,50413524   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083188
PNG
(7-Amino-6-chloro-1H-benzoimidazole-4-carboxylic ac...)
Show SMILES Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12
Show InChI InChI=1S/C15H18ClN5O/c16-10-5-9(13-14(12(10)17)19-7-18-13)15(22)20-11-6-21-3-1-8(11)2-4-21/h5,7-8,11H,1-4,6,17H2,(H,18,19)(H,20,22)
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0.240n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105650
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-is...)
Show SMILES CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C18H25ClN4O/c1-12(2)10-23-5-3-13(4-6-23)9-20-18(24)15-7-14(19)8-16-17(15)22-11-21-16/h7-8,11-13H,3-6,9-10H2,1-2H3,(H,20,24)(H,21,22)
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0.290n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatum membrane


J Med Chem 45: 4806-15 (2002)


Article DOI: 10.1021/jm020807x
BindingDB Entry DOI: 10.7270/Q2BZ65D3
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083197
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)
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0.290n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105650
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-is...)
Show SMILES CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C18H25ClN4O/c1-12(2)10-23-5-3-13(4-6-23)9-20-18(24)15-7-14(19)8-16-17(15)22-11-21-16/h7-8,11-13H,3-6,9-10H2,1-2H3,(H,20,24)(H,21,22)
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0.290n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity to 5-hydroxytryptamine 4 receptor in rat striatum membrane


Bioorg Med Chem Lett 11: 2807-11 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(01)00517-0
BindingDB Entry DOI: 10.7270/Q29G5M3X
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083197
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)
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0.290n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105649
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-bu...)
Show SMILES CCCCN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C18H25ClN4O/c1-2-3-6-23-7-4-13(5-8-23)11-20-18(24)15-9-14(19)10-16-17(15)22-12-21-16/h9-10,12-13H,2-8,11H2,1H3,(H,20,24)(H,21,22)
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0.320n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity to 5-hydroxytryptamine 4 receptor in rat striatum membrane


Bioorg Med Chem Lett 11: 2807-11 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(01)00517-0
BindingDB Entry DOI: 10.7270/Q29G5M3X
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105649
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-bu...)
Show SMILES CCCCN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C18H25ClN4O/c1-2-3-6-23-7-4-13(5-8-23)11-20-18(24)15-9-14(19)10-16-17(15)22-12-21-16/h9-10,12-13H,2-8,11H2,1H3,(H,20,24)(H,21,22)
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0.320n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatum membrane


J Med Chem 45: 4806-15 (2002)


Article DOI: 10.1021/jm020807x
BindingDB Entry DOI: 10.7270/Q2BZ65D3
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105640
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-pe...)
Show SMILES CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C19H27ClN4O/c1-2-3-4-7-24-8-5-14(6-9-24)12-21-19(25)16-10-15(20)11-17-18(16)23-13-22-17/h10-11,13-14H,2-9,12H2,1H3,(H,21,25)(H,22,23)
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0.540n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity to 5-hydroxytryptamine 4 receptor in rat striatum membrane


Bioorg Med Chem Lett 11: 2807-11 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(01)00517-0
BindingDB Entry DOI: 10.7270/Q29G5M3X
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105640
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-pe...)
Show SMILES CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3nc[nH]c23)CC1
Show InChI InChI=1S/C19H27ClN4O/c1-2-3-4-7-24-8-5-14(6-9-24)12-21-19(25)16-10-15(20)11-17-18(16)23-13-22-17/h10-11,13-14H,2-9,12H2,1H3,(H,21,25)(H,22,23)
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0.540n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatum membrane


J Med Chem 45: 4806-15 (2002)


Article DOI: 10.1021/jm020807x
BindingDB Entry DOI: 10.7270/Q2BZ65D3
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083191
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)N[C@H]2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)/t13-/m0/s1
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0.760n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083195
PNG
(1H-Benzoimidazole-4-carboxylic acid ((S)-4-ethyl-1...)
Show SMILES CCC1CCN(C)C[C@H]1NC(=O)c1cccc2nc[nH]c12
Show InChI InChI=1S/C16H22N4O/c1-3-11-7-8-20(2)9-14(11)19-16(21)12-5-4-6-13-15(12)18-10-17-13/h4-6,10-11,14H,3,7-9H2,1-2H3,(H,17,18)(H,19,21)/t11?,14-/m1/s1
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2.60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083192
PNG
(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Show SMILES O=C(NC1CN2CCC1CC2)c1cccc2nc[nH]c12
Show InChI InChI=1S/C15H18N4O/c20-15(11-2-1-3-12-14(11)17-9-16-12)18-13-8-19-6-4-10(13)5-7-19/h1-3,9-10,13H,4-8H2,(H,16,17)(H,18,20)
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3.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083192
PNG
(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Show SMILES O=C(NC1CN2CCC1CC2)c1cccc2nc[nH]c12
Show InChI InChI=1S/C15H18N4O/c20-15(11-2-1-3-12-14(11)17-9-16-12)18-13-8-19-6-4-10(13)5-7-19/h1-3,9-10,13H,4-8H2,(H,16,17)(H,18,20)
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3.70n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50105630
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(Cl)cc2nc[nH]c12
Show InChI InChI=1S/C14H17ClN4O/c1-19-4-2-10(3-5-19)18-14(20)11-6-9(15)7-12-13(11)17-8-16-12/h6-8,10H,2-5H2,1H3,(H,16,17)(H,18,20)
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30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50083198
PNG
(1H-Benzoimidazole-4-carboxylic acid ((R)-4-ethyl-1...)
Show SMILES CCC1CCN(C)C[C@@H]1NC(=O)c1cccc2nc[nH]c12
Show InChI InChI=1S/C16H22N4O/c1-3-11-7-8-20(2)9-14(11)19-16(21)12-5-4-6-13-15(12)18-10-17-13/h4-6,10-11,14H,3,7-9H2,1-2H3,(H,17,18)(H,19,21)/t11?,14-/m0/s1
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38n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105630
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(Cl)cc2nc[nH]c12
Show InChI InChI=1S/C14H17ClN4O/c1-19-4-2-10(3-5-19)18-14(20)11-6-9(15)7-12-13(11)17-8-16-12/h6-8,10H,2-5H2,1H3,(H,16,17)(H,18,20)
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54n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity to 5-hydroxytryptamine 4 receptor in rat striatum membrane


Bioorg Med Chem Lett 11: 2807-11 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(01)00517-0
BindingDB Entry DOI: 10.7270/Q29G5M3X
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105630
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(Cl)cc2nc[nH]c12
Show InChI InChI=1S/C14H17ClN4O/c1-19-4-2-10(3-5-19)18-14(20)11-6-9(15)7-12-13(11)17-8-16-12/h6-8,10H,2-5H2,1H3,(H,16,17)(H,18,20)
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54n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50105630
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(Cl)cc2nc[nH]c12
Show InChI InChI=1S/C14H17ClN4O/c1-19-4-2-10(3-5-19)18-14(20)11-6-9(15)7-12-13(11)17-8-16-12/h6-8,10H,2-5H2,1H3,(H,16,17)(H,18,20)
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54n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatum membrane


J Med Chem 45: 4806-15 (2002)


Article DOI: 10.1021/jm020807x
BindingDB Entry DOI: 10.7270/Q2BZ65D3
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083197
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)
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168n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083197
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)
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168n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083188
PNG
(7-Amino-6-chloro-1H-benzoimidazole-4-carboxylic ac...)
Show SMILES Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12
Show InChI InChI=1S/C15H18ClN5O/c16-10-5-9(13-14(12(10)17)19-7-18-13)15(22)20-11-6-21-3-1-8(11)2-4-21/h5,7-8,11H,1-4,6,17H2,(H,18,19)(H,20,22)
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187n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083191
PNG
(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Show SMILES Clc1cc(C(=O)N[C@H]2CN3CCC2CC3)c2[nH]cnc2c1
Show InChI InChI=1S/C15H17ClN4O/c16-10-5-11(14-12(6-10)17-8-18-14)15(21)19-13-7-20-3-1-9(13)2-4-20/h5-6,8-9,13H,1-4,7H2,(H,17,18)(H,19,21)/t13-/m0/s1
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205n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50413524
PNG
(CHEMBL472219 | SC-53606)
Show SMILES C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12
Show InChI InChI=1S/C17H21ClN4O/c1-17-4-2-5-22(17)6-3-11(17)9-19-16(23)13-7-12(18)8-14-15(13)21-10-20-14/h7-8,10-11H,2-6,9H2,1H3,(H,19,23)(H,20,21)/t11-,17-/m0/s1
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251n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Binding affinity at 5HT3 receptor


Bioorg Med Chem 17: 2607-22 (2009)


Article DOI: 10.1016/j.bmc.2008.11.045
BindingDB Entry DOI: 10.7270/Q2CJ8DCG
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083192
PNG
(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Show SMILES O=C(NC1CN2CCC1CC2)c1cccc2nc[nH]c12
Show InChI InChI=1S/C15H18N4O/c20-15(11-2-1-3-12-14(11)17-9-16-12)18-13-8-19-6-4-10(13)5-7-19/h1-3,9-10,13H,4-8H2,(H,16,17)(H,18,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083195
PNG
(1H-Benzoimidazole-4-carboxylic acid ((S)-4-ethyl-1...)
Show SMILES CCC1CCN(C)C[C@H]1NC(=O)c1cccc2nc[nH]c12
Show InChI InChI=1S/C16H22N4O/c1-3-11-7-8-20(2)9-14(11)19-16(21)12-5-4-6-13-15(12)18-10-17-13/h4-6,10-11,14H,3,7-9H2,1-2H3,(H,17,18)(H,19,21)/t11?,14-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083192
PNG
(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Show SMILES O=C(NC1CN2CCC1CC2)c1cccc2nc[nH]c12
Show InChI InChI=1S/C15H18N4O/c20-15(11-2-1-3-12-14(11)17-9-16-12)18-13-8-19-6-4-10(13)5-7-19/h1-3,9-10,13H,4-8H2,(H,16,17)(H,18,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptor


Bioorg Med Chem Lett 6: 1195-1198 (1996)


Article DOI: 10.1016/0960-894X(96)00200-4
BindingDB Entry DOI: 10.7270/Q23J3DGF
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50083198
PNG
(1H-Benzoimidazole-4-carboxylic acid ((R)-4-ethyl-1...)
Show SMILES CCC1CCN(C)C[C@@H]1NC(=O)c1cccc2nc[nH]c12
Show InChI InChI=1S/C16H22N4O/c1-3-11-7-8-20(2)9-14(11)19-16(21)12-5-4-6-13-15(12)18-10-17-13/h4-6,10-11,14H,3,7-9H2,1-2H3,(H,17,18)(H,19,21)/t11?,14-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.


J Med Chem 42: 5020-8 (2000)


Article DOI: 10.1021/jm991076c
BindingDB Entry DOI: 10.7270/Q2H132PJ
More data for this
Ligand-Target Pair