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4 similar compounds to monomer 50093798

Compile data set for download or QSAR
Wt: 308.4
BDBM50086856
Wt: 308.4
BDBM50086859
Wt: 294.3
BDBM50158504
Wt: 393.5
BDBM50216203

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50086856,50086859,50158504,50216203   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50086856
PNG
(CHEMBL147279 | N-((S)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m0/s1
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Article
PubMed
4.60n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50086856
PNG
(CHEMBL147279 | N-((S)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m0/s1
UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
430n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]ketanserin


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50158504
PNG
(CHEMBL387725 | N-(1-benzylpyrrolidin-3-yl)-2-pheny...)
Show SMILES O=C(Cc1ccccc1)NC1CCN(Cc2ccccc2)C1
Show InChI InChI=1/C19H22N2O/c22-19(13-16-7-3-1-4-8-16)20-18-11-12-21(15-18)14-17-9-5-2-6-10-17/h1-10,18H,11-15H2,(H,20,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to rat MCH1 receptor


J Med Chem 47: 6864-74 (2004)


Article DOI: 10.1021/jm040084c
BindingDB Entry DOI: 10.7270/Q2280737
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50086859
PNG
(CHEMBL147226 | N-((R)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against binding of Dopamine receptor D2 by displacement of [3H]-spiperone


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50086859
PNG
(CHEMBL147226 | N-((R)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against binding of 5-hydroxytryptamine 1A receptor from striata of male Wistar rats by displacement of [3H]-...


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50086859
PNG
(CHEMBL147226 | N-((R)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]-ketanserin


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Membrane-bound transcription factor site-1 protease


(Homo sapiens (Human))
BDBM50216203
PNG
(4-diethylaminomethyl-N-pyrrolidin-3-yl-N-(2-o-toly...)
Show SMILES CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1C)C1CCNC1
Show InChI InChI=1/C25H35N3O/c1-4-27(5-2)19-21-10-12-23(13-11-21)25(29)28(24-14-16-26-18-24)17-15-22-9-7-6-8-20(22)3/h6-13,24,26H,4-5,14-19H2,1-3H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development-Groton Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human S1P expressed in CHOK1 cells


Bioorg Med Chem Lett 17: 4411-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.031
BindingDB Entry DOI: 10.7270/Q26M36JG
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50086856
PNG
(CHEMBL147279 | N-((S)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against binding of Dopamine receptor D2 by displacement of [3H]-spiperone


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair