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14 similar compounds to monomer 50087113

Compile data set for download or QSAR
Wt: 419.4
BDBM50087088
Wt: 467.4
BDBM50087090
Wt: 509.5
BDBM50087091
Wt: 481.5
BDBM50087098
Wt: 481.5
BDBM50087100
Wt: 467.4
BDBM50087104
Wt: 419.4
BDBM50087106
Wt: 447.4
BDBM50087107
Wt: 481.5
BDBM50087111
Wt: 495.5
BDBM50087114
Wt: 511.5
BDBM50087116
Wt: 497.4
BDBM50087119
Wt: 418.4
BDBM50105262
Wt: 480.4
BDBM50105263

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50087088,50087090,50087091,50087098,50087100,50087104,50087106,50087107,50087111,50087114,50087116,50087119,50105262,50105263   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087104
PNG
(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C25H27N2O5P/c26-24(21-9-5-2-6-10-21)33(31,32)17-22(25(30)27-16-23(28)29)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22,24H,15-17,26H2,(H,27,30)(H,28,29)(H,31,32)/p+1/t22-,24+/m1/s1
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0.940n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087106
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15-,19+/m0/s1
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1.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50105262
PNG
(2-{3-[(1-Amino-ethyl)-hydroxy-phosphinoyl]-2-biphe...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C([O-])=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/t14-,15-,19-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)


J Med Chem 44: 3523-30 (2001)


Article DOI: 10.1021/jm0102248
BindingDB Entry DOI: 10.7270/Q2QN67HK
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087088
PNG
((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15?,19+/m0/s1
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1.40n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50105263
PNG
(2-{3-[(Amino-phenyl-methyl)-hydroxy-phosphinoyl]-2...)
Show SMILES C[C@H](NC(=O)[C@@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H]([NH3+])c1ccccc1)C([O-])=O
Show InChI InChI=1S/C26H29N2O5P/c1-18(26(30)31)28-25(29)23(17-34(32,33)24(27)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-24H,16-17,27H2,1H3,(H,28,29)(H,30,31)(H,32,33)/t18-,23-,24-/m0/s1
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2n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)


J Med Chem 44: 3523-30 (2001)


Article DOI: 10.1021/jm0102248
BindingDB Entry DOI: 10.7270/Q2QN67HK
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50105262
PNG
(2-{3-[(1-Amino-ethyl)-hydroxy-phosphinoyl]-2-biphe...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C([O-])=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/t14-,15-,19-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)


J Med Chem 44: 3523-30 (2001)


Article DOI: 10.1021/jm0102248
BindingDB Entry DOI: 10.7270/Q2QN67HK
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087106
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15-,19+/m0/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087100
PNG
((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)C([NH3+])c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c1-18(26(30)31)28-25(29)23(17-34(32,33)24(27)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-24H,16-17,27H2,1H3,(H,28,29)(H,30,31)(H,32,33)/p+1/t18-,23+,24?/m0/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087114
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES Cc1ccc(cc1)C([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c1-19-12-14-22(15-13-19)25(28)35(33,34)18-23(16-20-8-4-2-5-9-20)26(30)29-24(27(31)32)17-21-10-6-3-7-11-21/h2-15,23-25H,16-18,28H2,1H3,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25?/m1/s1
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3.10n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087098
PNG
((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Show SMILES [NH3+]C(c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c27-24(21-14-8-3-9-15-21)34(32,33)18-22(16-19-10-4-1-5-11-19)25(29)28-23(26(30)31)17-20-12-6-2-7-13-20/h1-15,22-24H,16-18,27H2,(H,28,29)(H,30,31)(H,32,33)/p+1/t22-,23+,24?/m1/s1
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4.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087111
PNG
((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c27-24(21-14-8-3-9-15-21)34(32,33)18-22(16-19-10-4-1-5-11-19)25(29)28-23(26(30)31)17-20-12-6-2-7-13-20/h1-15,22-24H,16-18,27H2,(H,28,29)(H,30,31)(H,32,33)/p+1/t22-,23+,24+/m1/s1
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4.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50105263
PNG
(2-{3-[(Amino-phenyl-methyl)-hydroxy-phosphinoyl]-2...)
Show SMILES C[C@H](NC(=O)[C@@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H]([NH3+])c1ccccc1)C([O-])=O
Show InChI InChI=1S/C26H29N2O5P/c1-18(26(30)31)28-25(29)23(17-34(32,33)24(27)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-24H,16-17,27H2,1H3,(H,28,29)(H,30,31)(H,32,33)/t18-,23-,24-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)


J Med Chem 44: 3523-30 (2001)


Article DOI: 10.1021/jm0102248
BindingDB Entry DOI: 10.7270/Q2QN67HK
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087119
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-ethylca...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C26H29N2O6P/c27-24(21-9-5-2-6-10-21)35(33,34)17-22(25(30)28-23(16-29)26(31)32)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22-24,29H,15-17,27H2,(H,28,30)(H,31,32)(H,33,34)/p+1/t22-,23+,24+/m1/s1
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4.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087088
PNG
((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15?,19+/m0/s1
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5.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087107
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4-methyl...)
Show SMILES CC(C)C[C@H](CP(O)(=O)C([NH3+])c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H31N2O5P/c1-16(2)13-19(15-31(29,30)21(24)18-11-7-4-8-12-18)22(26)25-20(23(27)28)14-17-9-5-3-6-10-17/h3-12,16,19-21H,13-15,24H2,1-2H3,(H,25,26)(H,27,28)(H,29,30)/p+1/t19-,20+,21?/m1/s1
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7.60n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087090
PNG
(C-({2-[(Carboxy-phenyl-methyl)-carbamoyl]-3-phenyl...)
Show SMILES [NH3+]C(c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](C(O)=O)c1ccccc1
Show InChI InChI=1S/C25H27N2O5P/c26-23(20-14-8-3-9-15-20)33(31,32)17-21(16-18-10-4-1-5-11-18)24(28)27-22(25(29)30)19-12-6-2-7-13-19/h1-15,21-23H,16-17,26H2,(H,27,28)(H,29,30)(H,31,32)/p+1/t21-,22+,23?/m1/s1
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10n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087116
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-propylc...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H]([NH3+])c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O6P/c1-18(30)24(27(32)33)29-26(31)23(17-36(34,35)25(28)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-25,30H,16-17,28H2,1H3,(H,29,31)(H,32,33)(H,34,35)/p+1/t18?,23-,24+,25+/m1/s1
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10.2n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087119
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-ethylca...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C26H29N2O6P/c27-24(21-9-5-2-6-10-21)35(33,34)17-22(25(30)28-23(16-29)26(31)32)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22-24,29H,15-17,27H2,(H,28,30)(H,31,32)(H,33,34)/p+1/t22-,23+,24+/m1/s1
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11.8n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087100
PNG
((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)C([NH3+])c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c1-18(26(30)31)28-25(29)23(17-34(32,33)24(27)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-24H,16-17,27H2,1H3,(H,28,29)(H,30,31)(H,32,33)/p+1/t18-,23+,24?/m0/s1
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14n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087116
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-propylc...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H]([NH3+])c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O6P/c1-18(30)24(27(32)33)29-26(31)23(17-36(34,35)25(28)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-25,30H,16-17,28H2,1H3,(H,29,31)(H,32,33)(H,34,35)/p+1/t18?,23-,24+,25+/m1/s1
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32.5n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087104
PNG
(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C25H27N2O5P/c26-24(21-9-5-2-6-10-21)33(31,32)17-22(25(30)27-16-23(28)29)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22,24H,15-17,26H2,(H,27,30)(H,28,29)(H,31,32)/p+1/t22-,24+/m1/s1
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32.8n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087111
PNG
((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c27-24(21-14-8-3-9-15-21)34(32,33)18-22(16-19-10-4-1-5-11-19)25(29)28-23(26(30)31)17-20-12-6-2-7-13-20/h1-15,22-24H,16-18,27H2,(H,28,29)(H,30,31)(H,32,33)/p+1/t22-,23+,24+/m1/s1
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70n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087098
PNG
((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Show SMILES [NH3+]C(c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c27-24(21-14-8-3-9-15-21)34(32,33)18-22(16-19-10-4-1-5-11-19)25(29)28-23(26(30)31)17-20-12-6-2-7-13-20/h1-15,22-24H,16-18,27H2,(H,28,29)(H,30,31)(H,32,33)/p+1/t22-,23+,24?/m1/s1
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104n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087107
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4-methyl...)
Show SMILES CC(C)C[C@H](CP(O)(=O)C([NH3+])c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H31N2O5P/c1-16(2)13-19(15-31(29,30)21(24)18-11-7-4-8-12-18)22(26)25-20(23(27)28)14-17-9-5-3-6-10-17/h3-12,16,19-21H,13-15,24H2,1-2H3,(H,25,26)(H,27,28)(H,29,30)/p+1/t19-,20+,21?/m1/s1
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110n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50087106
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15-,19+/m0/s1
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120n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087091
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES Cc1ccc(C([NH3+])P(O)(=O)C[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(O)=O)c(C)c1
Show InChI InChI=1S/C28H33N2O5P/c1-19-13-14-24(20(2)15-19)26(29)36(34,35)18-23(16-21-9-5-3-6-10-21)27(31)30-25(28(32)33)17-22-11-7-4-8-12-22/h3-15,23,25-26H,16-18,29H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t23-,25+,26?/m1/s1
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130n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087114
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES Cc1ccc(cc1)C([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c1-19-12-14-22(15-13-19)25(28)35(33,34)18-23(16-20-8-4-2-5-9-20)26(30)29-24(27(31)32)17-21-10-6-3-7-11-21/h2-15,23-25H,16-18,28H2,1H3,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25?/m1/s1
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160n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087091
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES Cc1ccc(C([NH3+])P(O)(=O)C[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(O)=O)c(C)c1
Show InChI InChI=1S/C28H33N2O5P/c1-19-13-14-24(20(2)15-19)26(29)36(34,35)18-23(16-21-9-5-3-6-10-21)27(31)30-25(28(32)33)17-22-11-7-4-8-12-22/h3-15,23,25-26H,16-18,29H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t23-,25+,26?/m1/s1
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230n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087090
PNG
(C-({2-[(Carboxy-phenyl-methyl)-carbamoyl]-3-phenyl...)
Show SMILES [NH3+]C(c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](C(O)=O)c1ccccc1
Show InChI InChI=1S/C25H27N2O5P/c26-23(20-14-8-3-9-15-20)33(31,32)17-21(16-18-10-4-1-5-11-18)24(28)27-22(25(29)30)19-12-6-2-7-13-19/h1-15,21-23H,16-17,26H2,(H,27,28)(H,29,30)(H,31,32)/p+1/t21-,22+,23?/m1/s1
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1.10E+3n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50087119
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-ethylca...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C26H29N2O6P/c27-24(21-9-5-2-6-10-21)35(33,34)17-22(25(30)28-23(16-29)26(31)32)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22-24,29H,15-17,27H2,(H,28,30)(H,31,32)(H,33,34)/p+1/t22-,23+,24+/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50087104
PNG
(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C25H27N2O5P/c26-24(21-9-5-2-6-10-21)33(31,32)17-22(25(30)27-16-23(28)29)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22,24H,15-17,26H2,(H,27,30)(H,28,29)(H,31,32)/p+1/t22-,24+/m1/s1
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7.80E+3n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50087111
PNG
((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29N2O5P/c27-24(21-14-8-3-9-15-21)34(32,33)18-22(16-19-10-4-1-5-11-19)25(29)28-23(26(30)31)17-20-12-6-2-7-13-20/h1-15,22-24H,16-18,27H2,(H,28,29)(H,30,31)(H,32,33)/p+1/t22-,23+,24+/m1/s1
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1.30E+4n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50087116
PNG
(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-propylc...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H]([NH3+])c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O6P/c1-18(30)24(27(32)33)29-26(31)23(17-36(34,35)25(28)22-10-6-3-7-11-22)16-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2-15,18,23-25,30H,16-17,28H2,1H3,(H,29,31)(H,32,33)(H,34,35)/p+1/t18?,23-,24+,25+/m1/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair