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17 similar compounds to monomer 50087124

Compile data set for download or QSAR
Wt: 498.5
BDBM50087137
Wt: 570.5
BDBM50087123
Wt: 498.5
BDBM50087127
Wt: 516.4
BDBM50087129
Wt: 484.4
BDBM50087444
Wt: 516.4
BDBM50087126
Wt: 558.5
BDBM50087128
Wt: 498.5
BDBM50087131
Wt: 498.5
BDBM50087133
Wt: 484.4
BDBM50087136
Wt: 502.4
BDBM50087171
Wt: 502.4
BDBM50087279
Wt: 558.5
BDBM50087286
Wt: 544.5
BDBM50087437
Wt: 540.5
BDBM50087438
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50087137,50087123,50087127,50087129,50087444,50087126,50087128,50087131,50087133,50087136,50087171,50087279,50087286,50087437,50087438   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087127
PNG
(CHEMBL3426637)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)20-6-2-5-18(12-20)26(34)32-22-7-3-4-17(13-22)23-14-19(8-9-21(23)15-30)27(35)33-25-10-11-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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n/an/a<1n/an/an/an/an/an/a



Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087126
PNG
(CHEMBL3426639)
Show SMILES COC(=O)c1ccc(F)c(c1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H22F2N4O4/c1-38-28(37)18-7-8-23(29)22(13-18)27(36)33-20-4-2-3-16(11-20)21-12-17(5-6-19(21)14-31)26(35)34-25-9-10-32-15-24(25)30/h2-13,15H,14,31H2,1H3,(H,33,36)(H,32,34,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087128
PNG
(CHEMBL3426635)
Show SMILES CC[C@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C31H28F2N4O4/c1-3-18(2)41-31(40)22-9-10-25(32)28(15-22)37-29(38)20-6-4-5-19(13-20)24-14-21(7-8-23(24)16-34)30(39)36-27-11-12-35-17-26(27)33/h4-15,17-18H,3,16,34H2,1-2H3,(H,37,38)(H,35,36,39)/t18-/m0/s1
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087437
PNG
(CHEMBL3426634)
Show SMILES CCCOC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C30H26F2N4O4/c1-2-12-40-30(39)21-8-9-24(31)27(15-21)36-28(37)19-5-3-4-18(13-19)23-14-20(6-7-22(23)16-33)29(38)35-26-10-11-34-17-25(26)32/h3-11,13-15,17H,2,12,16,33H2,1H3,(H,36,37)(H,34,35,38)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087129
PNG
(CHEMBL3426633)
Show SMILES COC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C28H22F2N4O4/c1-38-28(37)19-7-8-22(29)25(13-19)34-26(35)17-4-2-3-16(11-17)21-12-18(5-6-20(21)14-31)27(36)33-24-9-10-32-15-23(24)30/h2-13,15H,14,31H2,1H3,(H,34,35)(H,32,33,36)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087438
PNG
(CHEMBL3426632)
Show SMILES CCC(C)OC(=O)c1cccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C31H29FN4O4/c1-3-19(2)40-31(39)23-8-5-9-25(15-23)35-29(37)21-7-4-6-20(14-21)26-16-22(10-11-24(26)17-33)30(38)36-28-12-13-34-18-27(28)32/h4-16,18-19H,3,17,33H2,1-2H3,(H,35,37)(H,34,36,38)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087444
PNG
(CHEMBL3426626)
Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(c1)C(O)=O)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C27H21FN4O4/c28-23-15-30-10-9-24(23)32-26(34)18-7-8-20(14-29)22(13-18)16-3-1-4-17(11-16)25(33)31-21-6-2-5-19(12-21)27(35)36/h1-13,15H,14,29H2,(H,31,33)(H,35,36)(H,30,32,34)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087131
PNG
(CHEMBL3426624)
Show SMILES COC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)cc1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)17-7-9-22(10-8-17)32-26(34)19-4-2-3-18(13-19)23-14-20(5-6-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087133
PNG
(CHEMBL3426622)
Show SMILES COC(=O)c1cccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)20-6-3-7-22(13-20)32-26(34)18-5-2-4-17(12-18)23-14-19(8-9-21(23)15-30)27(35)33-25-10-11-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50087131
PNG
(CHEMBL3426624)
Show SMILES COC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)cc1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)17-7-9-22(10-8-17)32-26(34)19-4-2-3-18(13-19)23-14-20(5-6-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50087133
PNG
(CHEMBL3426622)
Show SMILES COC(=O)c1cccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)20-6-3-7-22(13-20)32-26(34)18-5-2-4-17(12-18)23-14-19(8-9-21(23)15-30)27(35)33-25-10-11-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087137
PNG
(CHEMBL3426731)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)18-7-5-17(6-8-18)26(34)32-22-4-2-3-19(13-22)23-14-20(9-10-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087123
PNG
(CHEMBL3426642)
Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(C(=O)OC2CCCC2)c1F)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C32H28F2N4O4/c33-26-18-36-14-13-27(26)37-31(40)21-11-12-22(17-35)25(16-21)19-5-3-6-20(15-19)30(39)38-28-10-4-9-24(29(28)34)32(41)42-23-7-1-2-8-23/h3-6,9-16,18,23H,1-2,7-8,17,35H2,(H,38,39)(H,36,37,40)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087126
PNG
(CHEMBL3426639)
Show SMILES COC(=O)c1ccc(F)c(c1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H22F2N4O4/c1-38-28(37)18-7-8-23(29)22(13-18)27(36)33-20-4-2-3-16(11-20)21-12-17(5-6-19(21)14-31)26(35)34-25-9-10-32-15-24(25)30/h2-13,15H,14,31H2,1H3,(H,33,36)(H,32,34,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087127
PNG
(CHEMBL3426637)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)20-6-2-5-18(12-20)26(34)32-22-7-3-4-17(13-22)23-14-19(8-9-21(23)15-30)27(35)33-25-10-11-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087128
PNG
(CHEMBL3426635)
Show SMILES CC[C@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C31H28F2N4O4/c1-3-18(2)41-31(40)22-9-10-25(32)28(15-22)37-29(38)20-6-4-5-19(13-20)24-14-21(7-8-23(24)16-34)30(39)36-27-11-12-35-17-26(27)33/h4-15,17-18H,3,16,34H2,1-2H3,(H,37,38)(H,35,36,39)/t18-/m0/s1
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087129
PNG
(CHEMBL3426633)
Show SMILES COC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C28H22F2N4O4/c1-38-28(37)19-7-8-22(29)25(13-19)34-26(35)17-4-2-3-16(11-17)21-12-18(5-6-20(21)14-31)27(36)33-24-9-10-32-15-23(24)30/h2-13,15H,14,31H2,1H3,(H,34,35)(H,32,33,36)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087131
PNG
(CHEMBL3426624)
Show SMILES COC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)cc1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)17-7-9-22(10-8-17)32-26(34)19-4-2-3-18(13-19)23-14-20(5-6-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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n/an/a 4.10n/an/an/an/an/an/a



Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087133
PNG
(CHEMBL3426622)
Show SMILES COC(=O)c1cccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)20-6-3-7-22(13-20)32-26(34)18-5-2-4-17(12-18)23-14-19(8-9-21(23)15-30)27(35)33-25-10-11-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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n/an/a 125n/an/an/an/an/an/a



Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087136
PNG
(CHEMBL3426732)
Show SMILES NCc1ccc(cc1-c1cccc(NC(=O)c2ccc(cc2)C(O)=O)c1)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C27H21FN4O4/c28-23-15-30-11-10-24(23)32-26(34)19-8-9-20(14-29)22(13-19)18-2-1-3-21(12-18)31-25(33)16-4-6-17(7-5-16)27(35)36/h1-13,15H,14,29H2,(H,31,33)(H,35,36)(H,30,32,34)
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n/an/a 1n/an/an/an/an/an/a



Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087137
PNG
(CHEMBL3426731)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1cccc(c1)-c1cc(ccc1CN)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C28H23FN4O4/c1-37-28(36)18-7-5-17(6-8-18)26(34)32-22-4-2-3-19(13-22)23-14-20(9-10-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087171
PNG
(CHEMBL3426646)
Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(C(O)=O)c1F)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C27H20F2N4O4/c28-21-14-31-10-9-22(21)32-26(35)17-7-8-18(13-30)20(12-17)15-3-1-4-16(11-15)25(34)33-23-6-2-5-19(24(23)29)27(36)37/h1-12,14H,13,30H2,(H,33,34)(H,36,37)(H,31,32,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087279
PNG
(CHEMBL3426643)
Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cc(ccc1F)C(O)=O)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C27H20F2N4O4/c28-21-7-6-18(27(36)37)12-24(21)33-25(34)16-3-1-2-15(10-16)20-11-17(4-5-19(20)13-30)26(35)32-23-8-9-31-14-22(23)29/h1-12,14H,13,30H2,(H,33,34)(H,36,37)(H,31,32,35)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087123
PNG
(CHEMBL3426642)
Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(C(=O)OC2CCCC2)c1F)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C32H28F2N4O4/c33-26-18-36-14-13-27(26)37-31(40)21-11-12-22(17-35)25(16-21)19-5-3-6-20(15-19)30(39)38-28-10-4-9-24(29(28)34)32(41)42-23-7-1-2-8-23/h3-6,9-16,18,23H,1-2,7-8,17,35H2,(H,38,39)(H,36,37,40)
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087286
PNG
(CHEMBL3426636)
Show SMILES CC[C@@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)c1
Show InChI InChI=1S/C31H28F2N4O4/c1-3-18(2)41-31(40)22-9-10-25(32)28(15-22)37-29(38)20-6-4-5-19(13-20)24-14-21(7-8-23(24)16-34)30(39)36-27-11-12-35-17-26(27)33/h4-15,17-18H,3,16,34H2,1-2H3,(H,37,38)(H,35,36,39)/t18-/m1/s1
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Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair