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15 similar compounds to monomer 50440599

Compile data set for download or QSAR
Wt: 389.5
BDBM50088735
Wt: 461.6
BDBM50088737
Wt: 405.5
BDBM50088745
Wt: 433.6
BDBM50088748
Wt: 419.6
BDBM50088749
Wt: 391.5
BDBM50088750
Wt: 377.5
BDBM50088751
Wt: 377.5
BDBM50088713
Wt: 419.6
BDBM50088722
Wt: 377.5
BDBM50088727
Wt: 391.5
BDBM50088728
Wt: 419.6
BDBM50088731
Wt: 453.6
BDBM50143738
Wt: 377.5
BDBM50144234
Wt: 484.6
BDBM50299386

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50088735,50088737,50088745,50088748,50088749,50088750,50088751,50088713,50088722,50088727,50088728,50088731,50143738,50144234,50299386   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50144234
PNG
(4-((R)-(S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-ami...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23?
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0.300n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1


Bioorg Med Chem Lett 14: 2109-12 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.051
BindingDB Entry DOI: 10.7270/Q25B01X4
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088713
PNG
(4-((1S,3S,5R)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23-
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0.400n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088749
PNG
(CHEMBL13286 | N,N-Diethyl-4-[phenyl-((1R,3S,5S)-8-...)
Show SMILES CCCN1[C@H]2CC[C@@H]1C[C@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C27H37N3O/c1-4-18-29-24-16-17-25(29)20-26(19-24)30(22-10-8-7-9-11-22)23-14-12-21(13-15-23)27(31)28(5-2)6-3/h7-15,24-26H,4-6,16-20H2,1-3H3/t24-,25+,26-
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3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088750
PNG
(CHEMBL13143 | N,N-Diethyl-4-[((1R,3S,5S)-8-methyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-27(5-2)25(29)19-11-13-21(14-12-19)28(20-9-7-6-8-10-20)24-17-22-15-16-23(18-24)26(22)3/h6-14,22-24H,4-5,15-18H2,1-3H3/t22-,23+,24-
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7n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088748
PNG
(CHEMBL13454 | N-Butyl-4-[((1R,3S,5S)-8-methyl-8-az...)
Show SMILES CCCCN(CCC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C28H39N3O/c1-4-6-19-30(18-5-2)28(32)22-12-14-24(15-13-22)31(23-10-8-7-9-11-23)27-20-25-16-17-26(21-27)29(25)3/h7-15,25-27H,4-6,16-21H2,1-3H3/t25-,26+,27-
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8n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088727
PNG
(CHEMBL13316 | N-Ethyl-N-methyl-4-[((1R,3S,5S)-8-me...)
Show SMILES CCN(C)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-4-25(2)24(28)18-10-12-20(13-11-18)27(19-8-6-5-7-9-19)23-16-21-14-15-22(17-23)26(21)3/h5-13,21-23H,4,14-17H2,1-3H3/t21-,22+,23-
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18n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088731
PNG
(4-[((1R,3S,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-...)
Show SMILES CCCN(CCC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-4-17-29(18-5-2)27(31)21-11-13-23(14-12-21)30(22-9-7-6-8-10-22)26-19-24-15-16-25(20-26)28(24)3/h6-14,24-26H,4-5,15-20H2,1-3H3/t24-,25+,26-
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18n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088751
PNG
(4-((1R,3R,5S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23+
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19n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50299386
PNG
(4-((1-benzylpiperidin-4-yl)(4-carbamoylphenyl)amin...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C30H36N4O2/c1-3-33(4-2)30(36)25-12-16-27(17-13-25)34(26-14-10-24(11-15-26)29(31)35)28-18-20-32(21-19-28)22-23-8-6-5-7-9-23/h5-17,28H,3-4,18-22H2,1-2H3,(H2,31,35)
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32n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptor


Bioorg Med Chem Lett 19: 5999-6003 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.068
BindingDB Entry DOI: 10.7270/Q2XP7512
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088737
PNG
(CHEMBL275288 | N,N-Diethyl-4-[((1R,3R,5S)-8-hexyl-...)
Show SMILES CCCCCCN1[C@H]2CC[C@@H]1C[C@@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C30H43N3O/c1-4-7-8-12-21-32-27-19-20-28(32)23-29(22-27)33(25-13-10-9-11-14-25)26-17-15-24(16-18-26)30(34)31(5-2)6-3/h9-11,13-18,27-29H,4-8,12,19-23H2,1-3H3/t27-,28+,29+
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33n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088735
PNG
(CHEMBL12828 | {4-[((1R,3S,5S)-8-Methyl-8-aza-bicyc...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C25H31N3O/c1-26-22-13-14-23(26)18-24(17-22)28(20-7-3-2-4-8-20)21-11-9-19(10-12-21)25(29)27-15-5-6-16-27/h2-4,7-12,22-24H,5-6,13-18H2,1H3/t22-,23+,24-
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34n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088737
PNG
(CHEMBL275288 | N,N-Diethyl-4-[((1R,3R,5S)-8-hexyl-...)
Show SMILES CCCCCCN1[C@H]2CC[C@@H]1C[C@@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C30H43N3O/c1-4-7-8-12-21-32-27-19-20-28(32)23-29(22-27)33(25-13-10-9-11-14-25)26-17-15-24(16-18-26)30(34)31(5-2)6-3/h9-11,13-18,27-29H,4-8,12,19-23H2,1-3H3/t27-,28+,29+
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130n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088745
PNG
(4-((1R,3R,5S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCCN(CCC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C26H35N3O/c1-3-16-28(17-4-2)26(30)20-10-14-24(15-11-20)29(23-8-6-5-7-9-23)25-18-21-12-13-22(19-25)27-21/h5-11,14-15,21-22,25,27H,3-4,12-13,16-19H2,1-2H3/t21-,22+,25+
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131n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088722
PNG
(CHEMBL12765 | N,N-Diethyl-4-[phenyl-((1R,3R,5S)-8-...)
Show SMILES CCCN1[C@H]2CC[C@@H]1C[C@@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C27H37N3O/c1-4-18-29-24-16-17-25(29)20-26(19-24)30(22-10-8-7-9-11-22)23-14-12-21(13-15-23)27(31)28(5-2)6-3/h7-15,24-26H,4-6,16-20H2,1-3H3/t24-,25+,26+
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151n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088728
PNG
(CHEMBL13146 | N,N-Diethyl-4-[((1R,3R,5S)-8-methyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-27(5-2)25(29)19-11-13-21(14-12-19)28(20-9-7-6-8-10-20)24-17-22-15-16-23(18-24)26(22)3/h6-14,22-24H,4-5,15-18H2,1-3H3/t22-,23+,24+
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305n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50299386
PNG
(4-((1-benzylpiperidin-4-yl)(4-carbamoylphenyl)amin...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C30H36N4O2/c1-3-33(4-2)30(36)25-12-16-27(17-13-25)34(26-14-10-24(11-15-26)29(31)35)28-18-20-32(21-19-28)22-23-8-6-5-7-9-23/h5-17,28H,3-4,18-22H2,1-2H3,(H2,31,35)
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486n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]FK33824 from human cloned mu opioid receptor


Bioorg Med Chem Lett 19: 5999-6003 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.068
BindingDB Entry DOI: 10.7270/Q2XP7512
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088735
PNG
(CHEMBL12828 | {4-[((1R,3S,5S)-8-Methyl-8-aza-bicyc...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C25H31N3O/c1-26-22-13-14-23(26)18-24(17-22)28(20-7-3-2-4-8-20)21-11-9-19(10-12-21)25(29)27-15-5-6-16-27/h2-4,7-12,22-24H,5-6,13-18H2,1H3/t22-,23+,24-
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1.40E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088751
PNG
(4-((1R,3R,5S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23+
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1.59E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088748
PNG
(CHEMBL13454 | N-Butyl-4-[((1R,3S,5S)-8-methyl-8-az...)
Show SMILES CCCCN(CCC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C28H39N3O/c1-4-6-19-30(18-5-2)28(32)22-12-14-24(15-13-22)31(23-10-8-7-9-11-23)27-20-25-16-17-26(21-27)29(25)3/h7-15,25-27H,4-6,16-21H2,1-3H3/t25-,26+,27-
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1.73E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088722
PNG
(CHEMBL12765 | N,N-Diethyl-4-[phenyl-((1R,3R,5S)-8-...)
Show SMILES CCCN1[C@H]2CC[C@@H]1C[C@@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C27H37N3O/c1-4-18-29-24-16-17-25(29)20-26(19-24)30(22-10-8-7-9-11-22)23-14-12-21(13-15-23)27(31)28(5-2)6-3/h7-15,24-26H,4-6,16-20H2,1-3H3/t24-,25+,26+
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1.85E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088745
PNG
(4-((1R,3R,5S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCCN(CCC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C26H35N3O/c1-3-16-28(17-4-2)26(30)20-10-14-24(15-11-20)29(23-8-6-5-7-9-23)25-18-21-12-13-22(19-25)27-21/h5-11,14-15,21-22,25,27H,3-4,12-13,16-19H2,1-2H3/t21-,22+,25+
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2.95E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088727
PNG
(CHEMBL13316 | N-Ethyl-N-methyl-4-[((1R,3S,5S)-8-me...)
Show SMILES CCN(C)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-4-25(2)24(28)18-10-12-20(13-11-18)27(19-8-6-5-7-9-19)23-16-21-14-15-22(17-23)26(21)3/h5-13,21-23H,4,14-17H2,1-3H3/t21-,22+,23-
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4.35E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088750
PNG
(CHEMBL13143 | N,N-Diethyl-4-[((1R,3S,5S)-8-methyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-27(5-2)25(29)19-11-13-21(14-12-19)28(20-9-7-6-8-10-20)24-17-22-15-16-23(18-24)26(22)3/h6-14,22-24H,4-5,15-18H2,1-3H3/t22-,23+,24-
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4.83E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50144234
PNG
(4-((R)-(S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-ami...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23?
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5.04E+3n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for mu opioid receptor


Bioorg Med Chem Lett 14: 2109-12 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.051
BindingDB Entry DOI: 10.7270/Q25B01X4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088713
PNG
(4-((1S,3S,5R)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23-
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5.04E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088749
PNG
(CHEMBL13286 | N,N-Diethyl-4-[phenyl-((1R,3S,5S)-8-...)
Show SMILES CCCN1[C@H]2CC[C@@H]1C[C@H](C2)N(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C27H37N3O/c1-4-18-29-24-16-17-25(29)20-26(19-24)30(22-10-8-7-9-11-22)23-14-12-21(13-15-23)27(31)28(5-2)6-3/h7-15,24-26H,4-6,16-20H2,1-3H3/t24-,25+,26-
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5.79E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50299386
PNG
(4-((1-benzylpiperidin-4-yl)(4-carbamoylphenyl)amin...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C30H36N4O2/c1-3-33(4-2)30(36)25-12-16-27(17-13-25)34(26-14-10-24(11-15-26)29(31)35)28-18-20-32(21-19-28)22-23-8-6-5-7-9-23/h5-17,28H,3-4,18-22H2,1-2H3,(H2,31,35)
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6.18E+3n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptor


Bioorg Med Chem Lett 19: 5999-6003 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.068
BindingDB Entry DOI: 10.7270/Q2XP7512
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50088728
PNG
(CHEMBL13146 | N,N-Diethyl-4-[((1R,3R,5S)-8-methyl-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-27(5-2)25(29)19-11-13-21(14-12-19)28(20-9-7-6-8-10-20)24-17-22-15-16-23(18-24)26(22)3/h6-14,22-24H,4-5,15-18H2,1-3H3/t22-,23+,24+
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6.35E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50144234
PNG
(4-((R)-(S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-ami...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1C[C@@H]2CC[C@H](C1)N2)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-3-26(4-2)24(28)18-10-14-22(15-11-18)27(21-8-6-5-7-9-21)23-16-19-12-13-20(17-23)25-19/h5-11,14-15,19-20,23,25H,3-4,12-13,16-17H2,1-2H3/t19-,20+,23?
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n/an/an/an/a 12n/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1


Bioorg Med Chem Lett 14: 2109-12 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.051
BindingDB Entry DOI: 10.7270/Q25B01X4
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50143738
PNG
((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Show SMILES CC1(CCN(CC1)C(=O)c1ccccc1)N1CCC(CC1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H35N3O/c1-30(19-23-31(24-20-30)29(34)25-11-5-2-6-12-25)32-21-17-28(18-22-32)33(26-13-7-3-8-14-26)27-15-9-4-10-16-27/h2-16,28H,17-24H2,1H3
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n/an/a 453n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against monkey C-C chemokine receptor type 5.


J Med Chem 47: 1939-55 (2004)


Article DOI: 10.1021/jm031046g
BindingDB Entry DOI: 10.7270/Q2V12478
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50143738
PNG
((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Show SMILES CC1(CCN(CC1)C(=O)c1ccccc1)N1CCC(CC1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H35N3O/c1-30(19-23-31(24-20-30)29(34)25-11-5-2-6-12-25)32-21-17-28(18-22-32)33(26-13-7-3-8-14-26)27-15-9-4-10-16-27/h2-16,28H,17-24H2,1H3
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n/an/a 511n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.


J Med Chem 47: 1939-55 (2004)


Article DOI: 10.1021/jm031046g
BindingDB Entry DOI: 10.7270/Q2V12478
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50143738
PNG
((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Show SMILES CC1(CCN(CC1)C(=O)c1ccccc1)N1CCC(CC1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H35N3O/c1-30(19-23-31(24-20-30)29(34)25-11-5-2-6-12-25)32-21-17-28(18-22-32)33(26-13-7-3-8-14-26)27-15-9-4-10-16-27/h2-16,28H,17-24H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against human C-C chemokine receptor type 5.


J Med Chem 47: 1939-55 (2004)


Article DOI: 10.1021/jm031046g
BindingDB Entry DOI: 10.7270/Q2V12478
More data for this
Ligand-Target Pair