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16 similar compounds to monomer 50091105

Compile data set for download or QSAR
Wt: 409.4
BDBM50091099
Wt: 445.4
BDBM50091100
Wt: 395.4
BDBM50091101
Wt: 409.4
BDBM50091102
Wt: 423.4
BDBM50091103
Wt: 409.4
BDBM50091107
Wt: 409.4
BDBM50091108
Wt: 395.4
BDBM50091109
Wt: 394.4
BDBM50109661
Wt: 406.4
BDBM50109666
Wt: 405.4
BDBM50109667
Wt: 481.5
BDBM50122678
Wt: 497.5
BDBM50122682
Wt: 467.5
BDBM50122708
Wt: 480.5
BDBM50122709
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50091099,50091100,50091101,50091102,50091103,50091107,50091108,50091109,50109661,50109666,50109667,50122678,50122682,50122708,50122709   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EDNRA


()
BDBM50122678
PNG
(2'-Isobutoxymethyl-4'-oxazol-2-yl-biphenyl-2-sulfo...)
Show SMILES CC(C)COCc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C25H27N3O5S/c1-16(2)14-31-15-20-13-19(25-26-11-12-32-25)9-10-21(20)22-7-5-6-8-23(22)34(29,30)28-24-17(3)18(4)27-33-24/h5-13,16,28H,14-15H2,1-4H3
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0.200n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin A receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091101
PNG
(4'-Oxazol-4-yl-biphenyl-2-sulfonic acid (3,4-dimet...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2cocn2)c1C
Show InChI InChI=1S/C20H17N3O4S/c1-13-14(2)22-27-20(13)23-28(24,25)19-6-4-3-5-17(19)15-7-9-16(10-8-15)18-11-26-12-21-18/h3-12,23H,1-2H3
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0.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50122708
PNG
(2'-Isopropoxymethyl-4'-oxazol-2-yl-biphenyl-2-sulf...)
Show SMILES CC(C)OCc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C24H25N3O5S/c1-15(2)31-14-19-13-18(24-25-11-12-30-24)9-10-20(19)21-7-5-6-8-22(21)33(28,29)27-23-16(3)17(4)26-32-23/h5-13,15,27H,14H2,1-4H3
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0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin A receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50109666
PNG
(4'-Pyrimidin-2-yl-biphenyl-2-sulfonic acid (3,4-di...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ncccn2)c1C
Show InChI InChI=1S/C21H18N4O3S/c1-14-15(2)24-28-21(14)25-29(26,27)19-7-4-3-6-18(19)16-8-10-17(11-9-16)20-22-12-5-13-23-20/h3-13,25H,1-2H3
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0.900n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin A receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50122709
PNG
(2-[2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-oxaz...)
Show SMILES CN(C)C(=O)Cc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C24H24N4O5S/c1-15-16(2)26-33-23(15)27-34(30,31)21-8-6-5-7-20(21)19-10-9-17(24-25-11-12-32-24)13-18(19)14-22(29)28(3)4/h5-13,27H,14H2,1-4H3
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1n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin A receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50122682
PNG
(4'-Oxazol-2-yl-2'-styryl-biphenyl-2-sulfonic acid ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2\C=C/c2ccccc2)-c2ncco2)c1C
Show InChI InChI=1S/C28H23N3O4S/c1-19-20(2)30-35-27(19)31-36(32,33)26-11-7-6-10-25(26)24-15-14-23(28-29-16-17-34-28)18-22(24)13-12-21-8-4-3-5-9-21/h3-18,31H,1-2H3/b13-12-
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1.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin A receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091108
PNG
(4'-(4-Methyl-oxazol-2-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1coc(n1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-12-27-21(22-13)17-10-8-16(9-11-17)18-6-4-5-7-19(18)29(25,26)24-20-14(2)15(3)23-28-20/h4-12,24H,1-3H3
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2n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50109667
PNG
(4'-Pyridin-2-yl-biphenyl-2-sulfonic acid (3,4-dime...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ccccn2)c1C
Show InChI InChI=1S/C22H19N3O3S/c1-15-16(2)24-28-22(15)25-29(26,27)21-9-4-3-7-19(21)17-10-12-18(13-11-17)20-8-5-6-14-23-20/h3-14,25H,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin A receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091109
PNG
(4'-Oxazol-5-yl-biphenyl-2-sulfonic acid (3,4-dimet...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2cnco2)c1C
Show InChI InChI=1S/C20H17N3O4S/c1-13-14(2)22-27-20(13)23-28(24,25)19-6-4-3-5-17(19)15-7-9-16(10-8-15)18-11-21-12-26-18/h3-12,23H,1-2H3
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3.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091107
PNG
(4'-(5-Methyl-oxazol-2-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1cnc(o1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-12-22-21(27-13)17-10-8-16(9-11-17)18-6-4-5-7-19(18)29(25,26)24-20-14(2)15(3)23-28-20/h4-12,24H,1-3H3
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11n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091103
PNG
(4'-(4,5-Dimethyl-oxazol-2-yl)-biphenyl-2-sulfonic ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2nc(C)c(C)o2)c1C
Show InChI InChI=1S/C22H21N3O4S/c1-13-14(2)24-29-21(13)25-30(26,27)20-8-6-5-7-19(20)17-9-11-18(12-10-17)22-23-15(3)16(4)28-22/h5-12,25H,1-4H3
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16n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091102
PNG
(4'-Oxazol-2-ylmethyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-14-15(2)23-28-21(14)24-29(25,26)19-6-4-3-5-18(19)17-9-7-16(8-10-17)13-20-22-11-12-27-20/h3-12,24H,13H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50109661
PNG
(4'-(1H-Imidazol-2-yl)-biphenyl-2-sulfonic acid (3,...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ncc[nH]2)c1C
Show InChI InChI=1S/C20H18N4O3S/c1-13-14(2)23-27-20(13)24-28(25,26)18-6-4-3-5-17(18)15-7-9-16(10-8-15)19-21-11-12-22-19/h3-12,24H,1-2H3,(H,21,22)
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44n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin A receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091099
PNG
(4'-(2-Methyl-oxazol-4-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1nc(co1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-14(2)23-28-21(13)24-29(25,26)20-7-5-4-6-18(20)16-8-10-17(11-9-16)19-12-27-15(3)22-19/h4-12,24H,1-3H3
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70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50122682
PNG
(4'-Oxazol-2-yl-2'-styryl-biphenyl-2-sulfonic acid ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2\C=C/c2ccccc2)-c2ncco2)c1C
Show InChI InChI=1S/C28H23N3O4S/c1-19-20(2)30-35-27(19)31-36(32,33)26-11-7-6-10-25(26)24-15-14-23(28-29-16-17-34-28)18-22(24)13-12-21-8-4-3-5-9-21/h3-18,31H,1-2H3/b13-12-
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1.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin B receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50091100
PNG
(4'-Benzooxazol-2-yl-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2nc3ccccc3o2)c1C
Show InChI InChI=1S/C24H19N3O4S/c1-15-16(2)26-31-23(15)27-32(28,29)22-10-6-3-7-19(22)17-11-13-18(14-12-17)24-25-20-8-4-5-9-21(20)30-24/h3-14,27H,1-2H3
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2.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Human Endothelin A receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50122678
PNG
(2'-Isobutoxymethyl-4'-oxazol-2-yl-biphenyl-2-sulfo...)
Show SMILES CC(C)COCc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C25H27N3O5S/c1-16(2)14-31-15-20-13-19(25-26-11-12-32-25)9-10-21(20)22-7-5-6-8-23(22)34(29,30)28-24-17(3)18(4)27-33-24/h5-13,16,28H,14-15H2,1-4H3
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4.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin B receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50109667
PNG
(4'-Pyridin-2-yl-biphenyl-2-sulfonic acid (3,4-dime...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ccccn2)c1C
Show InChI InChI=1S/C22H19N3O3S/c1-15-16(2)24-28-22(15)25-29(26,27)21-9-4-3-7-19(21)17-10-12-18(13-11-17)20-8-5-6-14-23-20/h3-14,25H,1-2H3
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6.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin B receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50122709
PNG
(2-[2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-oxaz...)
Show SMILES CN(C)C(=O)Cc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C24H24N4O5S/c1-15-16(2)26-33-23(15)27-34(30,31)21-8-6-5-7-20(21)19-10-9-17(24-25-11-12-32-24)13-18(19)14-22(29)28(3)4/h5-13,27H,14H2,1-4H3
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7.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin B receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50122708
PNG
(2'-Isopropoxymethyl-4'-oxazol-2-yl-biphenyl-2-sulf...)
Show SMILES CC(C)OCc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)-c1ncco1
Show InChI InChI=1S/C24H25N3O5S/c1-15(2)31-14-19-13-18(24-25-11-12-30-24)9-10-20(19)21-7-5-6-8-22(21)33(28,29)27-23-16(3)17(4)26-32-23/h5-13,15,27H,14H2,1-4H3
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1.10E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human endothelin B receptor expressed in CHO cells


J Med Chem 46: 125-37 (2002)


Article DOI: 10.1021/jm020289q
BindingDB Entry DOI: 10.7270/Q2348M3R
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091107
PNG
(4'-(5-Methyl-oxazol-2-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1cnc(o1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-12-22-21(27-13)17-10-8-16(9-11-17)18-6-4-5-7-19(18)29(25,26)24-20-14(2)15(3)23-28-20/h4-12,24H,1-3H3
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1.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091103
PNG
(4'-(4,5-Dimethyl-oxazol-2-yl)-biphenyl-2-sulfonic ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2nc(C)c(C)o2)c1C
Show InChI InChI=1S/C22H21N3O4S/c1-13-14(2)24-29-21(13)25-30(26,27)20-8-6-5-7-19(20)17-9-11-18(12-10-17)22-23-15(3)16(4)28-22/h5-12,25H,1-4H3
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1.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50109666
PNG
(4'-Pyrimidin-2-yl-biphenyl-2-sulfonic acid (3,4-di...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ncccn2)c1C
Show InChI InChI=1S/C21H18N4O3S/c1-14-15(2)24-28-21(14)25-29(26,27)19-7-4-3-6-18(19)16-8-10-17(11-9-16)20-22-12-5-13-23-20/h3-13,25H,1-2H3
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1.60E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin B receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091101
PNG
(4'-Oxazol-4-yl-biphenyl-2-sulfonic acid (3,4-dimet...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2cocn2)c1C
Show InChI InChI=1S/C20H17N3O4S/c1-13-14(2)22-27-20(13)23-28(24,25)19-6-4-3-5-17(19)15-7-9-16(10-8-15)18-11-26-12-21-18/h3-12,23H,1-2H3
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2.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091102
PNG
(4'-Oxazol-2-ylmethyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-14-15(2)23-28-21(14)24-29(25,26)19-6-4-3-5-18(19)17-9-7-16(8-10-17)13-20-22-11-12-27-20/h3-12,24H,13H2,1-2H3
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3.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091109
PNG
(4'-Oxazol-5-yl-biphenyl-2-sulfonic acid (3,4-dimet...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2cnco2)c1C
Show InChI InChI=1S/C20H17N3O4S/c1-13-14(2)22-27-20(13)23-28(24,25)19-6-4-3-5-17(19)15-7-9-16(10-8-15)18-11-21-12-26-18/h3-12,23H,1-2H3
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7.80E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091100
PNG
(4'-Benzooxazol-2-yl-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2nc3ccccc3o2)c1C
Show InChI InChI=1S/C24H19N3O4S/c1-15-16(2)26-31-23(15)27-32(28,29)22-10-6-3-7-19(22)17-11-13-18(14-12-17)24-25-20-8-4-5-9-21(20)30-24/h3-14,27H,1-2H3
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9.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091108
PNG
(4'-(4-Methyl-oxazol-2-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1coc(n1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-12-27-21(22-13)17-10-8-16(9-11-17)18-6-4-5-7-19(18)29(25,26)24-20-14(2)15(3)23-28-20/h4-12,24H,1-3H3
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1.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50091099
PNG
(4'-(2-Methyl-oxazol-4-yl)-biphenyl-2-sulfonic acid...)
Show SMILES Cc1nc(co1)-c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H19N3O4S/c1-13-14(2)23-28-21(13)24-29(25,26)20-7-5-4-6-18(20)16-8-10-17(11-9-16)19-12-27-15(3)22-19/h4-12,24H,1-3H3
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1.10E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inihibition of Human Endothelin B receptor expressed in CHO Cells.


J Med Chem 43: 3111-7 (2000)


Article DOI: 10.1021/jm000105c
BindingDB Entry DOI: 10.7270/Q2DF6QFM
More data for this
Ligand-Target Pair
EDNRB


(Homo sapiens (Human))
BDBM50109661
PNG
(4'-(1H-Imidazol-2-yl)-biphenyl-2-sulfonic acid (3,...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ncc[nH]2)c1C
Show InChI InChI=1S/C20H18N4O3S/c1-13-14(2)23-27-20(13)24-28(25,26)18-6-4-3-5-17(18)15-7-9-16(10-8-15)19-21-11-12-22-19/h3-12,24H,1-2H3,(H,21,22)
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1.50E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to CHO cells stably expressing human Endothelin B receptor.


Bioorg Med Chem Lett 12: 517-20 (2002)


Article DOI: 10.1016/s0960-894x(01)00791-0
BindingDB Entry DOI: 10.7270/Q2GF0STQ
More data for this
Ligand-Target Pair