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13 similar compounds to monomer 50218907

Wt: 364.3
BDBM50091116
Wt: 482.5
BDBM50218904
Wt: 332.3
BDBM50218908
Wt: 482.5
BDBM50218913
Wt: 378.4
BDBM50218917
Wt: 378.4
BDBM50218919
Wt: 394.4
BDBM50218923
Wt: 468.5
BDBM50218927
Wt: 365.3
BDBM50254612
Wt: 432.3
BDBM50254692
Wt: 432.3
BDBM50254694
Wt: 378.4
BDBM50254695
Wt: 378.4
BDBM50254734

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50091116,50218904,50218908,50218913,50218917,50218919,50218923,50218927,50254612,50254692,50254694,50254695,50254734   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A3


(Homo sapiens (human))
BDBM50091116
PNG
(CHEMBL322983 | N-(2-Phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES O=C(Nc1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H16N4O/c28-23(16-9-3-1-4-10-16)25-22-21-19(18-13-7-8-14-20(18)24-22)15-27(26-21)17-11-5-2-6-12-17/h1-15H,(H,24,25,28)
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2n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50091116
PNG
(CHEMBL322983 | N-(2-Phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES O=C(Nc1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H16N4O/c28-23(16-9-3-1-4-10-16)25-22-21-19(18-13-7-8-14-20(18)24-22)15-27(26-21)17-11-5-2-6-12-17/h1-15H,(H,24,25,28)
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2.10n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Displacement of specific [125I]-AB-MECA binding at human adenosine A3 receptor expressed in CHO cells


J Med Chem 43: 3118-24 (2000)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50091116
PNG
(CHEMBL322983 | N-(2-Phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES O=C(Nc1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H16N4O/c28-23(16-9-3-1-4-10-16)25-22-21-19(18-13-7-8-14-20(18)24-22)15-27(26-21)17-11-5-2-6-12-17/h1-15H,(H,24,25,28)
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2.10n/an/an/an/an/an/an/an/a



National University of Singapore

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A3 receptor


Bioorg Med Chem Lett 21: 2898-905 (2011)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218923
PNG
(CHEMBL390407 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[...)
Show SMILES COc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O2/c1-30-18-13-11-17(12-14-18)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)16-7-3-2-4-8-16/h2-15H,1H3,(H,25,26,29)
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3.40n/an/an/an/an/an/an/an/a



National University of Singapore

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A3 receptor


Bioorg Med Chem Lett 21: 2898-905 (2011)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218923
PNG
(CHEMBL390407 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[...)
Show SMILES COc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O2/c1-30-18-13-11-17(12-14-18)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)16-7-3-2-4-8-16/h2-15H,1H3,(H,25,26,29)
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3.40n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
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4.30n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
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4.30n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218917
PNG
(CHEMBL242632 | N-(2-p-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-18(14-12-16)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)17-7-3-2-4-8-17/h2-15H,1H3,(H,25,26,29)
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4.40n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218917
PNG
(CHEMBL242632 | N-(2-p-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-18(14-12-16)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)17-7-3-2-4-8-17/h2-15H,1H3,(H,25,26,29)
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4.40n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254612
PNG
(CHEMBL454780 | N-(2-phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES O=C(Nc1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccncc1
Show InChI InChI=1S/C22H15N5O/c28-22(15-10-12-23-13-11-15)25-21-20-18(17-8-4-5-9-19(17)24-21)14-27(26-20)16-6-2-1-3-7-16/h1-14H,(H,24,25,28)
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5n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218927
PNG
(CHEMBL389318 | N-benzoyl-N-(2-phenyl-2H-pyrazolo[3...)
Show SMILES O=C(N(C(=O)c1ccccc1)c1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H20N4O2/c35-29(21-12-4-1-5-13-21)34(30(36)22-14-6-2-7-15-22)28-27-25(24-18-10-11-19-26(24)31-28)20-33(32-27)23-16-8-3-9-17-23/h1-20H
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6.10n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218927
PNG
(CHEMBL389318 | N-benzoyl-N-(2-phenyl-2H-pyrazolo[3...)
Show SMILES O=C(N(C(=O)c1ccccc1)c1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H20N4O2/c35-29(21-12-4-1-5-13-21)34(30(36)22-14-6-2-7-15-22)28-27-25(24-18-10-11-19-26(24)31-28)20-33(32-27)23-16-8-3-9-17-23/h1-20H
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6.10n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254695
PNG
(3-methyl-N-(2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-...)
Show SMILES Cc1cccc(c1)C(=O)Nc1nc2ccccc2c2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-9-17(14-16)24(29)26-23-22-20(19-12-5-6-13-21(19)25-23)15-28(27-22)18-10-3-2-4-11-18/h2-15H,1H3,(H,25,26,29)
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6.30n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254734
PNG
(4-methyl-N-(2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1nc2ccccc2c2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-17(14-12-16)24(29)26-23-22-20(19-9-5-6-10-21(19)25-23)15-28(27-22)18-7-3-2-4-8-18/h2-15H,1H3,(H,25,26,29)
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11.5n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218913
PNG
(CHEMBL230853 | N-benzoyl-N-(2-phenyl-2H-pyrazolo[3...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(nc1ccccc21)N(C(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C31H22N4O2/c1-21-11-10-16-24(19-21)34-20-26-25-17-8-9-18-27(25)32-29(28(26)33-34)35(30(36)22-12-4-2-5-13-22)31(37)23-14-6-3-7-15-23/h2-20H,1H3
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23.3n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218904
PNG
(CHEMBL389962 | N-benzoyl-N-(2-p-tolyl-2H-pyrazolo[...)
Show SMILES Cc1ccc(cc1)-n1cc2c(n1)c(nc1ccccc21)N(C(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C31H22N4O2/c1-21-16-18-24(19-17-21)34-20-26-25-14-8-9-15-27(25)32-29(28(26)33-34)35(30(36)22-10-4-2-5-11-22)31(37)23-12-6-3-7-13-23/h2-20H,1H3
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30n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
PDB

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57n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
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57n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50218908
PNG
(CHEMBL242422 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[...)
Show SMILES COc1ccc(cc1)-n1cc2c(n1)c(NC(C)=O)nc1ccccc21
Show InChI InChI=1S/C19H16N4O2/c1-12(24)20-19-18-16(15-5-3-4-6-17(15)21-19)11-23(22-18)13-7-9-14(25-2)10-8-13/h3-11H,1-2H3,(H,20,21,24)
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102n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254692
PNG
(CHEMBL465096 | N-(2-(4-(trifluoromethyl)phenyl)-2H...)
Show SMILES FC(F)(F)c1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H15F3N4O/c25-24(26,27)16-10-12-17(13-11-16)31-14-19-18-8-4-5-9-20(18)28-22(21(19)30-31)29-23(32)15-6-2-1-3-7-15/h1-14H,(H,28,29,32)
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140n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218923
PNG
(CHEMBL390407 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[...)
Show SMILES COc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O2/c1-30-18-13-11-17(12-14-18)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)16-7-3-2-4-8-16/h2-15H,1H3,(H,25,26,29)
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250n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254694
PNG
(CHEMBL465945 | N-(2-phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1nc2ccccc2c2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C24H15F3N4O/c25-24(26,27)16-12-10-15(11-13-16)23(32)29-22-21-19(18-8-4-5-9-20(18)28-22)14-31(30-21)17-6-2-1-3-7-17/h1-14H,(H,28,29,32)
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415n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218917
PNG
(CHEMBL242632 | N-(2-p-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-18(14-12-16)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)17-7-3-2-4-8-17/h2-15H,1H3,(H,25,26,29)
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629n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218917
PNG
(CHEMBL242632 | N-(2-p-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1ccc(cc1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-18(14-12-16)28-15-20-19-9-5-6-10-21(19)25-23(22(20)27-28)26-24(29)17-7-3-2-4-8-17/h2-15H,1H3,(H,25,26,29)
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629n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
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2.68E+3n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218919
PNG
(CHEMBL242424 | N-(2-m-tolyl-2H-pyrazolo[3,4-c]quin...)
Show SMILES Cc1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-11-18(14-16)28-15-20-19-12-5-6-13-21(19)25-23(22(20)27-28)26-24(29)17-9-3-2-4-10-17/h2-15H,1H3,(H,25,26,29)
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2.86E+3n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptors; A1 & A2a


(Homo sapiens (human))
BDBM50218908
PNG
(CHEMBL242422 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[...)
Show SMILES COc1ccc(cc1)-n1cc2c(n1)c(NC(C)=O)nc1ccccc21
Show InChI InChI=1S/C19H16N4O2/c1-12(24)20-19-18-16(15-5-3-4-6-17(15)21-19)11-23(22-18)13-7-9-14(25-2)10-8-13/h3-11H,1-2H3,(H,20,21,24)
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2.88E+3n/an/an/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells


J Med Chem 50: 4061-74 (2007)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254695
PNG
(3-methyl-N-(2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-...)
Show SMILES Cc1cccc(c1)C(=O)Nc1nc2ccccc2c2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-16-8-7-9-17(14-16)24(29)26-23-22-20(19-12-5-6-13-21(19)25-23)15-28(27-22)18-10-3-2-4-11-18/h2-15H,1H3,(H,25,26,29)
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n/an/a 26n/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulati...


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254734
PNG
(4-methyl-N-(2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1nc2ccccc2c2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-16-11-13-17(14-12-16)24(29)26-23-22-20(19-9-5-6-10-21(19)25-23)15-28(27-22)18-7-3-2-4-8-18/h2-15H,1H3,(H,25,26,29)
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n/an/a 54n/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulati...


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50254612
PNG
(CHEMBL454780 | N-(2-phenyl-2H-pyrazolo[3,4-c]quino...)
Show SMILES O=C(Nc1nc2ccccc2c2cn(nc12)-c1ccccc1)c1ccncc1
Show InChI InChI=1S/C22H15N5O/c28-22(15-10-12-23-13-11-15)25-21-20-18(17-8-4-5-9-19(17)24-21)14-27(26-20)16-6-2-1-3-7-16/h1-14H,(H,24,25,28)
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n/an/a 41n/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulati...


Bioorg Med Chem 17: 401-10 (2008)

More data for this
Ligand-Target Pair