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9 similar compounds to monomer 50104474

Compile data set for download or QSAR
Wt: 620.1
BDBM50104458
Wt: 493.9
BDBM50104461
Wt: 675.1
BDBM50104468
Wt: 578.0
BDBM50104469
Wt: 725.2
BDBM50104476
Wt: 725.2
BDBM50104478
Wt: 682.1
BDBM50104484
Wt: 707.1
BDBM50104496
Wt: 577.0
BDBM50104499

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50104458,50104461,50104468,50104469,50104476,50104478,50104484,50104496,50104499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104458
PNG
(CHEMBL84794 | Phosphoric acid 12-[(R)-2-acetylamin...)
Show SMILES CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C31H43ClN3O6P/c1-24(36)35-29(22-25-23-34-28-18-12-10-16-26(25)28)31(37)33-20-14-8-6-4-2-3-5-7-9-15-21-40-42(38,39)41-30-19-13-11-17-27(30)32/h10-13,16-19,23,29,34H,2-9,14-15,20-22H2,1H3,(H,33,37)(H,35,36)(H,38,39)/t29-/m1/s1
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n/an/a 9.07E+4n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104461
PNG
(CHEMBL313922 | Phosphoric acid 6-[(R)-2-amino-3-(1...)
Show SMILES N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN3O5P/c24-19-10-4-6-12-22(19)32-33(29,30)31-14-8-2-1-7-13-26-23(28)20(25)15-17-16-27-21-11-5-3-9-18(17)21/h3-6,9-12,16,20,27H,1-2,7-8,13-15,25H2,(H,26,28)(H,29,30)/t20-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104469
PNG
(CHEMBL85749 | Phosphoric acid 12-[(S)-2-amino-3-(1...)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C29H41ClN3O5P/c30-25-16-10-12-18-28(25)38-39(35,36)37-20-14-8-6-4-2-1-3-5-7-13-19-32-29(34)26(31)21-23-22-33-27-17-11-9-15-24(23)27/h9-12,15-18,22,26,33H,1-8,13-14,19-21,31H2,(H,32,34)(H,35,36)/t26-/m0/s1
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n/an/a 1.51E+4n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104468
PNG
(CHEMBL313345 | Phosphoric acid 2-chloro-phenyl est...)
Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1)Oc1ccccc1Cl
Show InChI InChI=1S/C34H48ClN4O6P/c35-28-17-10-12-20-32(28)45-46(42,43)44-23-14-8-6-4-2-1-3-5-7-13-21-37-33(40)31(39-34(41)30-19-15-22-36-30)24-26-25-38-29-18-11-9-16-27(26)29/h9-12,16-18,20,25,30-31,36,38H,1-8,13-15,19,21-24H2,(H,37,40)(H,39,41)(H,42,43)/t30-,31-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104496
PNG
((R)-4-Amino-4-[(R)-1-{12-[(2-chloro-phenoxy)-hydro...)
Show SMILES N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C34H48ClN4O8P/c35-27-16-10-12-18-31(27)47-48(44,45)46-22-14-8-6-4-2-1-3-5-7-13-21-37-34(43)30(39-33(42)28(36)19-20-32(40)41)23-25-24-38-29-17-11-9-15-26(25)29/h9-12,15-18,24,28,30,38H,1-8,13-14,19-23,36H2,(H,37,43)(H,39,42)(H,40,41)(H,44,45)/t28-,30-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104478
PNG
(CHEMBL409072 | Phosphoric acid 12-[(R)-2-((R)-2-am...)
Show SMILES N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C38H50ClN4O6P/c39-32-21-13-15-23-36(32)49-50(46,47)48-25-17-8-6-4-2-1-3-5-7-16-24-41-38(45)35(27-30-28-42-34-22-14-12-20-31(30)34)43-37(44)33(40)26-29-18-10-9-11-19-29/h9-15,18-23,28,33,35,42H,1-8,16-17,24-27,40H2,(H,41,45)(H,43,44)(H,46,47)/t33-,35-/m1/s1
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n/an/a 2.21E+4n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104484
PNG
(CHEMBL314057 | Phosphoric acid 12-[(R)-2-benzoylam...)
Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)Oc1ccccc1Cl
Show InChI InChI=1S/C36H45ClN3O6P/c37-31-21-13-15-23-34(31)46-47(43,44)45-25-17-8-6-4-2-1-3-5-7-16-24-38-36(42)33(40-35(41)28-18-10-9-11-19-28)26-29-27-39-32-22-14-12-20-30(29)32/h9-15,18-23,27,33,39H,1-8,16-17,24-26H2,(H,38,42)(H,40,41)(H,43,44)/t33-/m1/s1
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n/an/a 7.30E+3n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104499
PNG
(CHEMBL313818 | Phosphoric acid 2-chloro-phenyl est...)
Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)CCCc1c[nH]c2ccccc12)Oc1ccccc1Cl
Show InChI InChI=1/C30H42ClN2O5P/c31-27-18-10-12-20-29(27)38-39(35,36)37-23-14-8-6-4-2-1-3-5-7-13-22-32-30(34)21-15-16-25-24-33-28-19-11-9-17-26(25)28/h9-12,17-20,24,33H,1-8,13-16,21-23H2,(H,32,34)(H,35,36)
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n/an/a 2.97E+4n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50104476
PNG
(CHEMBL315431 | Phosphoric acid 12-[(R)-2-((S)-2-am...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCCCCCCCOP(O)(=O)Oc1ccccc1Cl
Show InChI InChI=1S/C38H50ClN4O6P/c39-32-21-13-15-23-36(32)49-50(46,47)48-25-17-8-6-4-2-1-3-5-7-16-24-41-38(45)35(27-30-28-42-34-22-14-12-20-31(30)34)43-37(44)33(40)26-29-18-10-9-11-19-29/h9-15,18-23,28,33,35,42H,1-8,16-17,24-27,40H2,(H,41,45)(H,43,44)(H,46,47)/t33-,35+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines


Bioorg Med Chem Lett 11: 2581-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00507-8
BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair