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25 similar compounds to monomer 50105970

Wt: 424.4
BDBM50105936
Wt: 438.4
BDBM50105939
Wt: 438.4
BDBM50105940
Wt: 480.5
BDBM50105942
Wt: 438.4
BDBM50105945
Wt: 514.5
BDBM50105946
Wt: 492.4
BDBM50105947
Wt: 458.8
BDBM50105948
Wt: 493.3
BDBM50105950
Wt: 442.4
BDBM50105952
Wt: 481.5
BDBM50105957
Wt: 469.4
BDBM50105959
Wt: 438.4
BDBM50105960
Wt: 466.5
BDBM50105962
Wt: 452.4
BDBM50105963
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50105936,50105939,50105940,50105942,50105945,50105946,50105947,50105948,50105950,50105952,50105957,50105959,50105960,50105962,50105963   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50105936
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-phenyl-1,5-dihyd...)
Show SMILES Cc1[nH]n(-c2ccccc2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H16N4O5S/c1-12-18(20(26)24(23-12)13-7-3-2-4-8-13)21-22-19-15-10-6-5-9-14(15)17(11-16(19)25)30(27,28)29/h2-11,23,25H,1H3,(H,27,28,29)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105963
PNG
(4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-...)
Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C22H20N4O5S/c1-12-8-9-15(10-13(12)2)26-22(28)20(14(3)25-26)23-24-21-17-7-5-4-6-16(17)19(11-18(21)27)32(29,30)31/h4-11,25,27H,1-3H3,(H,29,30,31)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105940
PNG
(4-{N'-[1-(3,4-Dimethyl-phenyl)-5-oxo-1,5-dihydro-p...)
Show SMILES Cc1ccc(cc1C)-n1[nH]cc(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c1=O
Show InChI InChI=1S/C21H18N4O5S/c1-12-7-8-14(9-13(12)2)25-21(27)17(11-22-25)23-24-20-16-6-4-3-5-15(16)19(10-18(20)26)31(28,29)30/h3-11,22,26H,1-2H3,(H,28,29,30)
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105942
PNG
(4-{N'-[1-(3-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-...)
Show SMILES Cc1[nH]n(-c2cccc(c2)C(C)(C)C)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C24H24N4O5S/c1-14-21(23(30)28(27-14)16-9-7-8-15(12-16)24(2,3)4)25-26-22-18-11-6-5-10-17(18)20(13-19(22)29)34(31,32)33/h5-13,27,29H,1-4H3,(H,31,32,33)
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n/an/an/an/a 70n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105947
PNG
(3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(3-trifluorometh...)
Show SMILES Cc1[nH]n(-c2cccc(c2)C(F)(F)F)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C21H15F3N4O5S/c1-11-18(20(30)28(27-11)13-6-4-5-12(9-13)21(22,23)24)25-26-19-15-8-3-2-7-14(15)17(10-16(19)29)34(31,32)33/h2-10,27,29H,1H3,(H,31,32,33)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105946
PNG
(4-{N'-[1-(3,4-Dimethyl-phenyl)-5-oxo-3-phenyl-1,5-...)
Show SMILES Cc1ccc(cc1C)-n1[nH]c(c(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c1=O)-c1ccccc1
Show InChI InChI=1S/C27H22N4O5S/c1-16-12-13-19(14-17(16)2)31-27(33)26(24(30-31)18-8-4-3-5-9-18)29-28-25-21-11-7-6-10-20(21)23(15-22(25)32)37(34,35)36/h3-15,30,32H,1-2H3,(H,34,35,36)
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n/an/an/an/a 900n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105948
PNG
(4-{N'-[1-(3-Chloro-phenyl)-3-methyl-5-oxo-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2cccc(Cl)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H15ClN4O5S/c1-11-18(20(27)25(24-11)13-6-4-5-12(21)9-13)22-23-19-15-8-3-2-7-14(15)17(10-16(19)26)31(28,29)30/h2-10,24,26H,1H3,(H,28,29,30)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105952
PNG
(4-{N'-[1-(4-Fluoro-phenyl)-3-methyl-5-oxo-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2ccc(F)cc2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H15FN4O5S/c1-11-18(20(27)25(24-11)13-8-6-12(21)7-9-13)22-23-19-15-5-3-2-4-14(15)17(10-16(19)26)31(28,29)30/h2-10,24,26H,1H3,(H,28,29,30)
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n/an/an/an/a 500n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105945
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-p-tolyl-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2ccc(C)cc2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C21H18N4O5S/c1-12-7-9-14(10-8-12)25-21(27)19(13(2)24-25)22-23-20-16-6-4-3-5-15(16)18(11-17(20)26)31(28,29)30/h3-11,24,26H,1-2H3,(H,28,29,30)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105959
PNG
(3-Hydroxy-4-{N'-[3-methyl-1-(4-nitro-phenyl)-5-oxo...)
Show SMILES Cc1[nH]n(-c2ccc(cc2)[N+]([O-])=O)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H15N5O7S/c1-11-18(20(27)24(23-11)12-6-8-13(9-7-12)25(28)29)21-22-19-15-5-3-2-4-14(15)17(10-16(19)26)33(30,31)32/h2-10,23,26H,1H3,(H,30,31,32)
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n/an/an/an/a 400n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105950
PNG
(4-{N'-[1-(3,4-Dichloro-phenyl)-3-methyl-5-oxo-1,5-...)
Show SMILES Cc1[nH]n(-c2ccc(Cl)c(Cl)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H14Cl2N4O5S/c1-10-18(20(28)26(25-10)11-6-7-14(21)15(22)8-11)23-24-19-13-5-3-2-4-12(13)17(9-16(19)27)32(29,30)31/h2-9,25,27H,1H3,(H,29,30,31)
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105957
PNG
(4-{N'-[3-Amino-1-(4-tert-butyl-phenyl)-5-oxo-1,5-d...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1[nH]c(N)c(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c1=O
Show InChI InChI=1S/C23H23N5O5S/c1-23(2,3)13-8-10-14(11-9-13)28-22(30)20(21(24)27-28)26-25-19-16-7-5-4-6-15(16)18(12-17(19)29)34(31,32)33/h4-12,27,29H,24H2,1-3H3,(H,31,32,33)
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n/an/an/an/a 5.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105962
PNG
(3-Hydroxy-4-{N'-[1-(4-isopropyl-phenyl)-3-methyl-5...)
Show SMILES CC(C)c1ccc(cc1)-n1[nH]c(C)c(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c1=O
Show InChI InChI=1S/C23H22N4O5S/c1-13(2)15-8-10-16(11-9-15)27-23(29)21(14(3)26-27)24-25-22-18-7-5-4-6-17(18)20(12-19(22)28)33(30,31)32/h4-13,26,28H,1-3H3,(H,30,31,32)
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n/an/an/an/a 70n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105960
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-m-tolyl-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2cccc(C)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C21H18N4O5S/c1-12-6-5-7-14(10-12)25-21(27)19(13(2)24-25)22-23-20-16-9-4-3-8-15(16)18(11-17(20)26)31(28,29)30/h3-11,24,26H,1-2H3,(H,28,29,30)
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n/an/an/an/a 700n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105939
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-o-tolyl-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2ccccc2C)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C21H18N4O5S/c1-12-7-3-6-10-16(12)25-21(27)19(13(2)24-25)22-23-20-15-9-5-4-8-14(15)18(11-17(20)26)31(28,29)30/h3-11,24,26H,1-2H3,(H,28,29,30)
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair