BindingDB logo
myBDB logout

29 similar compounds to monomer 50064176

Compile data set for download or QSAR
Wt: 687.0
BDBM50106485
Wt: 288.4
BDBM50174654
Wt: 292.4
BDBM50407218
Wt: 462.7
BDBM50407226
Wt: 651.0
BDBM50405741
Wt: 639.0
BDBM50405740
Wt: 610.9
BDBM50405744
Wt: 554.8
BDBM50405745
Wt: 610.9
BDBM50405748
Wt: 610.9
BDBM50405755
Wt: 653.0
BDBM50405757
Wt: 624.9
BDBM50405760
Wt: 568.8
BDBM50422270
Wt: 540.8
BDBM50422271
Wt: 554.8
BDBM50422272
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50106485,50174654,50407218,50407226,50405741,50405740,50405744,50405745,50405748,50405755,50405757,50405760,50422270,50422271,50422272   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50106485
PNG
(1'-[8-(1-(2-methoxy-benzyl)-[4,4']bipiperidinyl)-o...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCN(CCCCCCCCN2CCC(CC2)C2CCN(Cc3ccccc3OC)CC2)CC1
Show InChI InChI=1S/C44H70N4O2/c1-49-43-15-9-7-13-41(43)35-47-31-21-39(22-32-47)37-17-27-45(28-18-37)25-11-5-3-4-6-12-26-46-29-19-38(20-30-46)40-23-33-48(34-24-40)36-42-14-8-10-16-44(42)50-2/h7-10,13-16,37-40H,3-6,11-12,17-36H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.60n/an/an/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic acetylcholine receptor M2


J Med Chem 44: 4035-8 (2001)


Article DOI: 10.1021/jm0155594
BindingDB Entry DOI: 10.7270/Q21R6PTT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50106485
PNG
(1'-[8-(1-(2-methoxy-benzyl)-[4,4']bipiperidinyl)-o...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCN(CCCCCCCCN2CCC(CC2)C2CCN(Cc3ccccc3OC)CC2)CC1
Show InChI InChI=1S/C44H70N4O2/c1-49-43-15-9-7-13-41(43)35-47-31-21-39(22-32-47)37-17-27-45(28-18-37)25-11-5-3-4-6-12-26-46-29-19-38(20-30-46)40-23-33-48(34-24-40)36-42-14-8-10-16-44(42)50-2/h7-10,13-16,37-40H,3-6,11-12,17-36H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15.3n/an/an/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Affinity for human M4 cloned muscarinic receptor subtype expressed in CHO-K1 cells


J Med Chem 44: 4035-8 (2001)


Article DOI: 10.1021/jm0155594
BindingDB Entry DOI: 10.7270/Q21R6PTT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50106485
PNG
(1'-[8-(1-(2-methoxy-benzyl)-[4,4']bipiperidinyl)-o...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCN(CCCCCCCCN2CCC(CC2)C2CCN(Cc3ccccc3OC)CC2)CC1
Show InChI InChI=1S/C44H70N4O2/c1-49-43-15-9-7-13-41(43)35-47-31-21-39(22-32-47)37-17-27-45(28-18-37)25-11-5-3-4-6-12-26-46-29-19-38(20-30-46)40-23-33-48(34-24-40)36-42-14-8-10-16-44(42)50-2/h7-10,13-16,37-40H,3-6,11-12,17-36H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19.8n/an/an/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Affinity for human M1 cloned muscarinic receptor subtype expressed in CHO-K1 cells


J Med Chem 44: 4035-8 (2001)


Article DOI: 10.1021/jm0155594
BindingDB Entry DOI: 10.7270/Q21R6PTT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50106485
PNG
(1'-[8-(1-(2-methoxy-benzyl)-[4,4']bipiperidinyl)-o...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCN(CCCCCCCCN2CCC(CC2)C2CCN(Cc3ccccc3OC)CC2)CC1
Show InChI InChI=1S/C44H70N4O2/c1-49-43-15-9-7-13-41(43)35-47-31-21-39(22-32-47)37-17-27-45(28-18-37)25-11-5-3-4-6-12-26-46-29-19-38(20-30-46)40-23-33-48(34-24-40)36-42-14-8-10-16-44(42)50-2/h7-10,13-16,37-40H,3-6,11-12,17-36H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
105n/an/an/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells


J Med Chem 44: 4035-8 (2001)


Article DOI: 10.1021/jm0155594
BindingDB Entry DOI: 10.7270/Q21R6PTT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50106485
PNG
(1'-[8-(1-(2-methoxy-benzyl)-[4,4']bipiperidinyl)-o...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCN(CCCCCCCCN2CCC(CC2)C2CCN(Cc3ccccc3OC)CC2)CC1
Show InChI InChI=1S/C44H70N4O2/c1-49-43-15-9-7-13-41(43)35-47-31-21-39(22-32-47)37-17-27-45(28-18-37)25-11-5-3-4-6-12-26-46-29-19-38(20-30-46)40-23-33-48(34-24-40)36-42-14-8-10-16-44(42)50-2/h7-10,13-16,37-40H,3-6,11-12,17-36H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
422n/an/an/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Affinity for human M3 cloned muscarinic receptor subtype expressed in CHO-K1 cells


J Med Chem 44: 4035-8 (2001)


Article DOI: 10.1021/jm0155594
BindingDB Entry DOI: 10.7270/Q21R6PTT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405740
PNG
(CHEMBL294613)
Show SMILES COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C40H70N4O2/c1-41(31-21-11-13-23-33-43(3)35-37-25-15-17-27-39(37)45-5)29-19-9-7-8-10-20-30-42(2)32-22-12-14-24-34-44(4)36-38-26-16-18-28-40(38)46-6/h15-18,25-28H,7-14,19-24,29-36H2,1-6H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor; Inactive up to 10 uM


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405748
PNG
(CHEMBL352334)
Show SMILES COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-43-37-25-15-13-23-35(37)33-41-31-21-11-5-9-19-29-39-27-17-7-3-4-8-18-28-40-30-20-10-6-12-22-32-42-34-36-24-14-16-26-38(36)44-2/h13-16,23-26,39-42H,3-12,17-22,27-34H2,1-2H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 646n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405755
PNG
(CHEMBL168235)
Show SMILES COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(33-35-23-13-15-25-37(35)43-3)31-21-11-9-19-29-39-27-17-7-5-6-8-18-28-40-30-20-10-12-22-32-42(2)34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50407226
PNG
(CHEMBL114738)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H54N4O/c1-33-28-19-11-10-18-27(28)26-32-25-17-9-8-16-24-31-22-14-6-3-2-5-13-21-30-23-15-7-4-12-20-29/h10-11,18-19,30-32H,2-9,12-17,20-26,29H2,1H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.55E+3n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405744
PNG
(CHEMBL114885)
Show SMILES COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(31-21-11-7-17-27-39-33-35-23-13-15-25-37(35)43-3)29-19-9-5-6-10-20-30-42(2)32-22-12-8-18-28-40-34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 603n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50407218
PNG
(CHEMBL324855)
Show SMILES CCN(CC)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C18H32N2O/c1-4-20(5-2)15-11-7-6-10-14-19-16-17-12-8-9-13-18(17)21-3/h8-9,12-13,19H,4-7,10-11,14-16H2,1-3H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]; inactive up to a co...


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Cholinesterase


(Homo sapiens (Human))
BDBM50422270
PNG
(CHEMBL422977)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C35H60N4O2/c1-40-34-22-12-10-20-32(34)30-38-28-18-8-6-16-26-36-24-14-4-3-5-15-25-37-27-17-7-9-19-29-39-31-33-21-11-13-23-35(33)41-2/h10-13,20-23,36-39H,3-9,14-19,24-31H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.72E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Cholinesterase


(Homo sapiens (Human))
BDBM50422271
PNG
(CHEMBL134382)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C33H56N4O2/c1-38-32-20-10-8-18-30(32)28-36-26-14-5-3-12-22-34-24-16-7-17-25-35-23-13-4-6-15-27-37-29-31-19-9-11-21-33(31)39-2/h8-11,18-21,34-37H,3-7,12-17,22-29H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.71E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50422271
PNG
(CHEMBL134382)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C33H56N4O2/c1-38-32-20-10-8-18-30(32)28-36-26-14-5-3-12-22-34-24-16-7-17-25-35-23-13-4-6-15-27-37-29-31-19-9-11-21-33(31)39-2/h8-11,18-21,34-37H,3-7,12-17,22-29H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.24E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE) of human erythrocytes


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50422270
PNG
(CHEMBL422977)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C35H60N4O2/c1-40-34-22-12-10-20-32(34)30-38-28-18-8-6-16-26-36-24-14-4-3-5-15-25-37-27-17-7-9-19-29-39-31-33-21-11-13-23-35(33)41-2/h10-13,20-23,36-39H,3-9,14-19,24-31H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.47E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE) of human erythrocytes


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Cholinesterase


(Homo sapiens (Human))
BDBM50422272
PNG
(CHEMBL302179)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C34H58N4O2/c1-39-33-21-11-9-19-31(33)29-37-27-17-7-5-15-25-35-23-13-3-4-14-24-36-26-16-6-8-18-28-38-30-32-20-10-12-22-34(32)40-2/h9-12,19-22,35-38H,3-8,13-18,23-30H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.38E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50422272
PNG
(CHEMBL302179)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C34H58N4O2/c1-39-33-21-11-9-19-31(33)29-37-27-17-7-5-15-25-35-23-13-3-4-14-24-36-26-16-6-8-18-28-38-30-32-20-10-12-22-34(32)40-2/h9-12,19-22,35-38H,3-8,13-18,23-30H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.46E+3n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE) of human erythrocytes


J Med Chem 41: 4186-9 (1998)

Checked by Author
Article DOI: 10.1021/jm9810452
BindingDB Entry DOI: 10.7270/Q2HH6KRM
More data for this
Ligand-Target Pair
Guanine nucleotide-binding protein G(k), alpha-3 subunit


(Homo sapiens (Human))
BDBM50174654
PNG
(1-(2-Methoxy-benzyl)-[4,4']bipiperidinyl | CHEMBL3...)
Show SMILES COc1ccccc1CN1CCC(CC1)C1CCNCC1
Show InChI InChI=1S/C18H28N2O/c1-21-18-5-3-2-4-17(18)14-20-12-8-16(9-13-20)15-6-10-19-11-7-15/h2-5,15-16,19H,6-14H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.88E+4n/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Concentration required to stimulate binding of [35S]GTP-gamma-S, with G alpha i3


J Med Chem 48: 6491-503 (2005)


Article DOI: 10.1021/jm050498l
BindingDB Entry DOI: 10.7270/Q2X34Z78
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405740
PNG
(CHEMBL294613)
Show SMILES COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C40H70N4O2/c1-41(31-21-11-13-23-33-43(3)35-37-25-15-17-27-39(37)45-5)29-19-9-7-8-10-20-30-42(2)32-22-12-14-24-34-44(4)36-38-26-16-18-28-40(38)46-6/h15-18,25-28H,7-14,19-24,29-36H2,1-6H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 162n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405745
PNG
(CHEMBL168736)
Show SMILES COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C34H58N4O2/c1-39-33-21-11-9-19-31(33)29-37-27-17-7-15-25-35-23-13-5-3-4-6-14-24-36-26-16-8-18-28-38-30-32-20-10-12-22-34(32)40-2/h9-12,19-22,35-38H,3-8,13-18,23-30H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 162n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405748
PNG
(CHEMBL352334)
Show SMILES COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-43-37-25-15-13-23-35(37)33-41-31-21-11-5-9-19-29-39-27-17-7-3-4-8-18-28-40-30-20-10-6-12-22-32-42-34-36-24-14-16-26-38(36)44-2/h13-16,23-26,39-42H,3-12,17-22,27-34H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 27.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405755
PNG
(CHEMBL168235)
Show SMILES COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(33-35-23-13-15-25-37(35)43-3)31-21-11-9-19-29-39-27-17-7-5-6-8-18-28-40-30-20-10-12-22-32-42(2)34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 166n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405744
PNG
(CHEMBL114885)
Show SMILES COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(31-21-11-7-17-27-39-33-35-23-13-15-25-37(35)43-3)29-19-9-5-6-10-20-30-42(2)32-22-12-8-18-28-40-34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 10.2n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405741
PNG
(CHEMBL167587)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C
Show InChI InChI=1S/C42H74N4O/c1-39-27-17-18-28-40(39)37-45-35-25-15-13-23-33-43-31-21-11-9-7-5-3-4-6-8-10-12-22-32-44-34-24-14-16-26-36-46-38-41-29-19-20-30-42(41)47-2/h17-20,27-30,43-46H,3-16,21-26,31-38H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 135n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405760
PNG
(CHEMBL167690)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C39H68N4O2/c1-44-38-26-16-14-24-36(38)34-42-32-22-12-10-20-30-40-28-18-8-6-4-3-5-7-9-19-29-41-31-21-11-13-23-33-43-35-37-25-15-17-27-39(37)45-2/h14-17,24-27,40-43H,3-13,18-23,28-35H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 37.1n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405757
PNG
(CHEMBL168786)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C41H72N4O2/c1-46-40-28-18-16-26-38(40)36-44-34-24-14-12-22-32-42-30-20-10-8-6-4-3-5-7-9-11-21-31-43-33-23-13-15-25-35-45-37-39-27-17-19-29-41(39)47-2/h16-19,26-29,42-45H,3-15,20-25,30-37H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 95.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50407218
PNG
(CHEMBL324855)
Show SMILES CCN(CC)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C18H32N2O/c1-4-20(5-2)15-11-7-6-10-14-19-16-17-12-8-9-13-18(17)21-3/h8-9,12-13,19H,4-7,10-11,14-16H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.51E+3n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50407226
PNG
(CHEMBL114738)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H54N4O/c1-33-28-19-11-10-18-27(28)26-32-25-17-9-8-16-24-31-22-14-6-3-2-5-13-21-30-23-15-7-4-12-20-29/h10-11,18-19,30-32H,2-9,12-17,20-26,29H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 91.2n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405744
PNG
(CHEMBL114885)
Show SMILES COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(31-21-11-7-17-27-39-33-35-23-13-15-25-37(35)43-3)29-19-9-5-6-10-20-30-42(2)32-22-12-8-18-28-40-34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 417n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405741
PNG
(CHEMBL167587)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C
Show InChI InChI=1S/C42H74N4O/c1-39-27-17-18-28-40(39)37-45-35-25-15-13-23-33-43-31-21-11-9-7-5-3-4-6-8-10-12-22-32-44-34-24-14-16-26-36-46-38-41-29-19-20-30-42(41)47-2/h17-20,27-30,43-46H,3-16,21-26,31-38H2,1-2H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.41E+3n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405760
PNG
(CHEMBL167690)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C39H68N4O2/c1-44-38-26-16-14-24-36(38)34-42-32-22-12-10-20-30-40-28-18-8-6-4-3-5-7-9-19-29-41-31-21-11-13-23-33-43-35-37-25-15-17-27-39(37)45-2/h14-17,24-27,40-43H,3-13,18-23,28-35H2,1-2H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.29E+3n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405744
PNG
(CHEMBL114885)
Show SMILES COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(31-21-11-7-17-27-39-33-35-23-13-15-25-37(35)43-3)29-19-9-5-6-10-20-30-42(2)32-22-12-8-18-28-40-34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 12.6n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405745
PNG
(CHEMBL168736)
Show SMILES COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C34H58N4O2/c1-39-33-21-11-9-19-31(33)29-37-27-17-7-15-25-35-23-13-5-3-4-6-14-24-36-26-16-8-18-28-38-30-32-20-10-12-22-34(32)40-2/h9-12,19-22,35-38H,3-8,13-18,23-30H2,1-2H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.46E+3n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50405757
PNG
(CHEMBL168786)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C41H72N4O2/c1-46-40-28-18-16-26-38(40)36-44-34-24-14-12-22-32-42-30-20-10-8-6-4-3-5-7-9-11-21-31-43-33-23-13-15-25-35-45-37-39-27-17-19-29-41(39)47-2/h16-19,26-29,42-45H,3-15,20-25,30-37H2,1-2H3
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.23E+3n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair