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8 similar compounds to monomer 50213348

Compile data set for download or QSAR
Wt: 374.4
BDBM50124518
Purchase
Wt: 336.4
BDBM50170866
Wt: 260.2
BDBM50170876
Wt: 382.4
BDBM50170883
Wt: 196.1
BDBM50170889
Wt: 420.4
BDBM50170884
Wt: 182.1
BDBM50170888
Wt: 286.2
BDBM50170879

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50124518,50170866,50170876,50170883,50170889,50170884,50170888,50170879   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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78n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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207n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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357n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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1.30E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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1.48E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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1.66E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170889
PNG
(CHEMBL3805798)
Show SMILES CC(C)CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H17N2O3P/c1-5(2)3-8-4-6(7)12(9,10)11/h5-6,8H,3-4,7H2,1-2H3,(H2,9,10,11)
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1.71E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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1.91E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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2.29E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170889
PNG
(CHEMBL3805798)
Show SMILES CC(C)CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H17N2O3P/c1-5(2)3-8-4-6(7)12(9,10)11/h5-6,8H,3-4,7H2,1-2H3,(H2,9,10,11)
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PubMed
2.51E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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3.02E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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3.24E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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4.45E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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8.23E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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9.51E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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2.11E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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2.38E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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2.62E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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2.90E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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6.44E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50124518
PNG
((E)-3-(3'-Adamantan-1-yl-4'-hydroxy-biphenyl-4-yl)...)
Show SMILES OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C25H26O3/c26-23-7-6-21(20-4-1-16(2-5-20)3-8-24(27)28)12-22(23)25-13-17-9-18(14-25)11-19(10-17)15-25/h1-8,12,17-19,26H,9-11,13-15H2,(H,27,28)/b8-3+
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n/an/an/an/a 200n/an/an/an/a



Università di Milano

Curated by ChEMBL


Assay Description
Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cells


J Med Chem 48: 4931-46 (2005)


Article DOI: 10.1021/jm049440h
BindingDB Entry DOI: 10.7270/Q2CN73DV
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50170866
PNG
((E)-3-(3'-Cyclohexylmethyl-4'-hydroxy-biphenyl-4-y...)
Show SMILES OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(CC2CCCCC2)c1
Show InChI InChI=1S/C22H24O3/c23-21-12-11-19(15-20(21)14-17-4-2-1-3-5-17)18-9-6-16(7-10-18)8-13-22(24)25/h6-13,15,17,23H,1-5,14H2,(H,24,25)/b13-8+
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n/an/an/an/a 5.30E+3n/an/an/an/a



Università di Milano

Curated by ChEMBL


Assay Description
Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor


J Med Chem 48: 4931-46 (2005)


Article DOI: 10.1021/jm049440h
BindingDB Entry DOI: 10.7270/Q2CN73DV
More data for this
Ligand-Target Pair