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23 similar compounds to monomer 13357

Wt: 408.9
BDBM50131116
Wt: 395.8
BDBM50131121
Wt: 395.8
BDBM50131122
Wt: 422.9
BDBM50131123
Wt: 394.8
BDBM50131125
Wt: 409.8
BDBM50131128
Wt: 410.8
BDBM50131132
Wt: 451.9
BDBM50131133
Wt: 422.9
BDBM50131135
Wt: 388.4
BDBM50131136
Wt: 393.8
BDBM50131140
Wt: 481.0
BDBM50131141
Wt: 454.9
BDBM50131142
Wt: 451.9
BDBM50131144
Wt: 454.9
BDBM50131145
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50131116,50131121,50131122,50131123,50131125,50131128,50131132,50131133,50131135,50131136,50131140,50131141,50131142,50131144,50131145   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM50131125
PNG
(2-(Pyridin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccn3)sc2c1
Show InChI InChI=1S/C20H15ClN4OS/c1-12-5-4-6-14(21)18(12)25-19(26)13-8-9-15-16(11-13)27-20(23-15)24-17-7-2-3-10-22-17/h2-11H,1H3,(H,25,26)(H,22,23,24)
PDB
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131145
PNG
(2-[6-(2-Hydroxy-ethylamino)-pyrimidin-4-ylamino]-b...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(NCCO)ncn3)sc2c1
Show InChI InChI=1S/C21H19ClN6O2S/c1-12-3-2-4-14(22)19(12)28-20(30)13-5-6-15-16(9-13)31-21(26-15)27-18-10-17(23-7-8-29)24-11-25-18/h2-6,9-11,29H,7-8H2,1H3,(H,28,30)(H2,23,24,25,26,27)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131121
PNG
(2-(Pyrazin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cnccn3)sc2c1
Show InChI InChI=1S/C19H14ClN5OS/c1-11-3-2-4-13(20)17(11)25-18(26)12-5-6-14-15(9-12)27-19(23-14)24-16-10-21-7-8-22-16/h2-10H,1H3,(H,25,26)(H,22,23,24)
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n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131122
PNG
(2-(Pyrimidin-4-ylamino)-benzothiazole-6-carboxylic...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccncn3)sc2c1
Show InChI InChI=1S/C19H14ClN5OS/c1-11-3-2-4-13(20)17(11)25-18(26)12-5-6-14-15(9-12)27-19(23-14)24-16-7-8-21-10-22-16/h2-10H,1H3,(H,25,26)(H,21,22,23,24)
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n/an/a 27n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131123
PNG
(2-(4-Ethyl-pyridin-2-ylamino)-benzothiazole-6-carb...)
Show SMILES CCc1ccnc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)c1
Show InChI InChI=1S/C22H19ClN4OS/c1-3-14-9-10-24-19(11-14)26-22-25-17-8-7-15(12-18(17)29-22)21(28)27-20-13(2)5-4-6-16(20)23/h4-12H,3H2,1-2H3,(H,27,28)(H,24,25,26)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131125
PNG
(2-(Pyridin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccn3)sc2c1
Show InChI InChI=1S/C20H15ClN4OS/c1-12-5-4-6-14(21)18(12)25-19(26)13-8-9-15-16(11-13)27-20(23-15)24-17-7-2-3-10-22-17/h2-11H,1H3,(H,25,26)(H,22,23,24)
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131128
PNG
(2-(4-Amino-pyridin-2-ylamino)-benzothiazole-6-carb...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(N)ccn3)sc2c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-14(21)18(11)26-19(27)12-5-6-15-16(9-12)28-20(24-15)25-17-10-13(22)7-8-23-17/h2-10H,1H3,(H,26,27)(H3,22,23,24,25)
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n/an/a 403n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131132
PNG
(2-(6-Amino-pyrimidin-4-ylamino)-benzothiazole-6-ca...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(N)ncn3)sc2c1
Show InChI InChI=1S/C19H15ClN6OS/c1-10-3-2-4-12(20)17(10)26-18(27)11-5-6-13-14(7-11)28-19(24-13)25-16-8-15(21)22-9-23-16/h2-9H,1H3,(H,26,27)(H3,21,22,23,24,25)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131133
PNG
(2-(6-Dimethylaminomethyl-pyridin-2-ylamino)-benzot...)
Show SMILES CN(C)Cc1cccc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)n1
Show InChI InChI=1S/C23H22ClN5OS/c1-14-6-4-8-17(24)21(14)28-22(30)15-10-11-18-19(12-15)31-23(26-18)27-20-9-5-7-16(25-20)13-29(2)3/h4-12H,13H2,1-3H3,(H,28,30)(H,25,26,27)
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131136
PNG
(2-(Pyridin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cc(C)c(NC(=O)c2ccc3nc(Nc4ccccn4)sc3c2)c(C)c1
Show InChI InChI=1S/C22H20N4OS/c1-13-10-14(2)20(15(3)11-13)26-21(27)16-7-8-17-18(12-16)28-22(24-17)25-19-6-4-5-9-23-19/h4-12H,1-3H3,(H,26,27)(H,23,24,25)
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n/an/a 138n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131135
PNG
(2-(4,6-Dimethyl-pyridin-2-ylamino)-benzothiazole-6...)
Show SMILES Cc1cc(C)nc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)c1
Show InChI InChI=1S/C22H19ClN4OS/c1-12-9-14(3)24-19(10-12)26-22-25-17-8-7-15(11-18(17)29-22)21(28)27-20-13(2)5-4-6-16(20)23/h4-11H,1-3H3,(H,27,28)(H,24,25,26)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131144
PNG
(2-(4-Dimethylaminomethyl-pyridin-2-ylamino)-benzot...)
Show SMILES CN(C)Cc1ccnc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)c1
Show InChI InChI=1S/C23H22ClN5OS/c1-14-5-4-6-17(24)21(14)28-22(30)16-7-8-18-19(12-16)31-23(26-18)27-20-11-15(9-10-25-20)13-29(2)3/h4-12H,13H2,1-3H3,(H,28,30)(H,25,26,27)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131141
PNG
(2-[6-(2-Amino-2-methyl-propylamino)-pyridin-2-ylam...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cccc(NCC(C)(C)N)n3)sc2c1
Show InChI InChI=1S/C24H25ClN6OS/c1-14-6-4-7-16(25)21(14)31-22(32)15-10-11-17-18(12-15)33-23(28-17)30-20-9-5-8-19(29-20)27-13-24(2,3)26/h4-12H,13,26H2,1-3H3,(H,31,32)(H2,27,28,29,30)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131142
PNG
(2-[2-(2-Hydroxy-ethylamino)-pyrimidin-4-ylamino]-b...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccnc(NCCO)n3)sc2c1
Show InChI InChI=1S/C21H19ClN6O2S/c1-12-3-2-4-14(22)18(12)28-19(30)13-5-6-15-16(11-13)31-21(25-15)27-17-7-8-23-20(26-17)24-9-10-29/h2-8,11,29H,9-10H2,1H3,(H,28,30)(H2,23,24,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131140
PNG
(2-Phenylamino-benzothiazole-6-carboxylic acid (2-c...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccc3)sc2c1
Show InChI InChI=1S/C21H16ClN3OS/c1-13-6-5-9-16(22)19(13)25-20(26)14-10-11-17-18(12-14)27-21(24-17)23-15-7-3-2-4-8-15/h2-12H,1H3,(H,23,24)(H,25,26)
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n/an/a 327n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131116
PNG
(2-(5-Methyl-pyridin-2-ylamino)-benzothiazole-6-car...)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc1
Show InChI InChI=1S/C21H17ClN4OS/c1-12-6-9-18(23-11-12)25-21-24-16-8-7-14(10-17(16)28-21)20(27)26-19-13(2)4-3-5-15(19)22/h3-11H,1-2H3,(H,26,27)(H,23,24,25)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair