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3 similar compounds to monomer 26550

Wt: 298.3
BDBM50131516
Wt: 354.4
BDBM50131524
Wt: 326.3
BDBM50131527

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50131516,50131524,50131527   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
PDB
MMDB

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n/an/a 185n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein 13


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein-9


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein 13


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of tumor necrosis factor-alpha converting enzyme


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
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n/an/a 259n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein 1


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein 1


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
PDB
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n/an/a 5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of tumor necrosis factor-alpha converting enzyme


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
PDB
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n/an/a 38n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein 13


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
PDB
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Article
PubMed
n/an/a 759n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP9


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
PDB
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n/an/a 331n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP1


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
PDB
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n/an/a 257n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP1


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131527
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C)C(=O)NO
Show InChI InChI=1S/C14H18N2O5S/c1-4-5-10-21-12-6-8-13(9-7-12)22(19,20)16(3)11(2)14(17)15-18/h6-9,11,18H,10H2,1-3H3,(H,15,17)/t11-/m1/s1
PDB
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n/an/a 68n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP9


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
PDB
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n/an/a 11n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP9


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...


J Med Chem 56: 8089-103 (2013)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
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n/an/a 17n/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...


J Med Chem 56: 8089-103 (2013)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
PDB
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein-9


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50131516
PNG
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C12H14N2O5S/c1-2-3-8-19-10-4-6-11(7-5-10)20(17,18)13-9-12(15)14-16/h4-7,13,16H,8-9H2,1H3,(H,14,15)
PDB
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n/an/a 753n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Matrix metalloprotein-9


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50131524
PNG
((R)-2-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N(C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H22N2O5S/c1-5-6-11-23-13-7-9-14(10-8-13)24(21,22)18(4)15(12(2)3)16(19)17-20/h7-10,12,15,20H,11H2,1-4H3,(H,17,19)/t15-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of tumor necrosis factor-alpha converting enzyme


Bioorg Med Chem Lett 13: 2799-803 (2003)

More data for this
Ligand-Target Pair