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8 similar compounds to monomer 50220842

Compile data set for download or QSAR
Wt: 266.3
BDBM50132136
Wt: 230.2
BDBM50132139
Wt: 166.1
BDBM50216524
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Wt: 152.1
BDBM50216533
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Wt: 196.2
BDBM50216538
Wt: 140.1
BDBM50216539
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Wt: 182.2
BDBM50216551
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Wt: 154.1
BDBM50220850
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50132136,50132139,50216524,50216533,50216538,50216539,50216551,50220850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216551
PNG
(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Show SMILES CCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H14N2O2/c1-2-3-4-5-7-6-8(9(12)13)11-10-7/h6H,2-5H2,1H3,(H,10,11)(H,12,13)
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72n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity at GPR109a


J Med Chem 51: 7653-62 (2008)


Article DOI: 10.1021/jm800896z
BindingDB Entry DOI: 10.7270/Q27D2TZ5
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50220850
PNG
(3-propyl-1H-pyrazole-5-carboxylic acid | 5-propyl-...)
Show SMILES CCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C7H10N2O2/c1-2-3-5-4-6(7(10)11)9-8-5/h4H,2-3H2,1H3,(H,8,9)(H,10,11)
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143n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.


J Med Chem 46: 3945-51 (2003)


Article DOI: 10.1021/jm030888c
BindingDB Entry DOI: 10.7270/Q2V988TK
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50132139
PNG
(5-(3-Phenyl-propyl)-1H-pyrazole-3-carboxylic acid ...)
Show SMILES OC(=O)c1cc(CCCc2ccccc2)[nH]n1
Show InChI InChI=1S/C13H14N2O2/c16-13(17)12-9-11(14-15-12)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,9H,4,7-8H2,(H,14,15)(H,16,17)
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6.30E+3n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.


J Med Chem 46: 3945-51 (2003)


Article DOI: 10.1021/jm030888c
BindingDB Entry DOI: 10.7270/Q2V988TK
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50132136
PNG
(5-Undecyl-1H-pyrazole-3-carboxylic acid | CHEMBL12...)
Show SMILES CCCCCCCCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C15H26N2O2/c1-2-3-4-5-6-7-8-9-10-11-13-12-14(15(18)19)17-16-13/h12H,2-11H2,1H3,(H,16,17)(H,18,19)
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2.14E+4n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.


J Med Chem 46: 3945-51 (2003)


Article DOI: 10.1021/jm030888c
BindingDB Entry DOI: 10.7270/Q2V988TK
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(Homo sapiens (Human))
BDBM50216551
PNG
(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Show SMILES CCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H14N2O2/c1-2-3-4-5-7-6-8(9(12)13)11-10-7/h6H,2-5H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a 1.86E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216524
PNG
(3-cyclobutyl-1H-pyrazole-5-carboxylic acid | 5-cyc...)
Show SMILES OC(=O)c1cc([nH]n1)C1CCC1
Show InChI InChI=1S/C8H10N2O2/c11-8(12)7-4-6(9-10-7)5-2-1-3-5/h4-5H,1-3H2,(H,9,10)(H,11,12)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216551
PNG
(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Show SMILES CCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H14N2O2/c1-2-3-4-5-7-6-8(9(12)13)11-10-7/h6H,2-5H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a 110n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216539
PNG
(3-ethyl-1H-pyrazole-5-carboxylic acid | 5-ethyl-1H...)
Show SMILES CCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C6H8N2O2/c1-2-4-3-5(6(9)10)8-7-4/h3H,2H2,1H3,(H,7,8)(H,9,10)
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n/an/an/an/a 79n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216533
PNG
(3-cyclopropyl-1H-pyrazole-5-carboxylic acid | 5-cy...)
Show SMILES OC(=O)c1cc([nH]n1)C1CC1
Show InChI InChI=1S/C7H8N2O2/c10-7(11)6-3-5(8-9-6)4-1-2-4/h3-4H,1-2H2,(H,8,9)(H,10,11)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220850
PNG
(3-propyl-1H-pyrazole-5-carboxylic acid | 5-propyl-...)
Show SMILES CCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C7H10N2O2/c1-2-3-5-4-6(7(10)11)9-8-5/h4H,2-3H2,1H3,(H,8,9)(H,10,11)
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n/an/an/an/a 182n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216524
PNG
(3-cyclobutyl-1H-pyrazole-5-carboxylic acid | 5-cyc...)
Show SMILES OC(=O)c1cc([nH]n1)C1CCC1
Show InChI InChI=1S/C8H10N2O2/c11-8(12)7-4-6(9-10-7)5-2-1-3-5/h4-5H,1-3H2,(H,9,10)(H,11,12)
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n/an/an/an/a 1.62E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216533
PNG
(3-cyclopropyl-1H-pyrazole-5-carboxylic acid | 5-cy...)
Show SMILES OC(=O)c1cc([nH]n1)C1CC1
Show InChI InChI=1S/C7H8N2O2/c10-7(11)6-3-5(8-9-6)4-1-2-4/h3-4H,1-2H2,(H,8,9)(H,10,11)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216539
PNG
(3-ethyl-1H-pyrazole-5-carboxylic acid | 5-ethyl-1H...)
Show SMILES CCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C6H8N2O2/c1-2-4-3-5(6(9)10)8-7-4/h3H,2H2,1H3,(H,7,8)(H,9,10)
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n/an/an/an/a 800n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216538
PNG
(3-hexyl-1H-pyrazole-5-carboxylic acid | CHEMBL2479...)
Show SMILES CCCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C10H16N2O2/c1-2-3-4-5-6-8-7-9(10(13)14)12-11-8/h7H,2-6H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a 5.60E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220850
PNG
(3-propyl-1H-pyrazole-5-carboxylic acid | 5-propyl-...)
Show SMILES CCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C7H10N2O2/c1-2-3-5-4-6(7(10)11)9-8-5/h4H,2-3H2,1H3,(H,8,9)(H,10,11)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216551
PNG
(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Show SMILES CCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H14N2O2/c1-2-3-4-5-7-6-8(9(12)13)11-10-7/h6H,2-5H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216533
PNG
(3-cyclopropyl-1H-pyrazole-5-carboxylic acid | 5-cy...)
Show SMILES OC(=O)c1cc([nH]n1)C1CC1
Show InChI InChI=1S/C7H8N2O2/c10-7(11)6-3-5(8-9-6)4-1-2-4/h3-4H,1-2H2,(H,8,9)(H,10,11)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216551
PNG
(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Show SMILES CCCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H14N2O2/c1-2-3-4-5-7-6-8(9(12)13)11-10-7/h6H,2-5H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a 110n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216524
PNG
(3-cyclobutyl-1H-pyrazole-5-carboxylic acid | 5-cyc...)
Show SMILES OC(=O)c1cc([nH]n1)C1CCC1
Show InChI InChI=1S/C8H10N2O2/c11-8(12)7-4-6(9-10-7)5-2-1-3-5/h4-5H,1-3H2,(H,9,10)(H,11,12)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216539
PNG
(3-ethyl-1H-pyrazole-5-carboxylic acid | 5-ethyl-1H...)
Show SMILES CCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C6H8N2O2/c1-2-4-3-5(6(9)10)8-7-4/h3H,2H2,1H3,(H,7,8)(H,9,10)
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n/an/an/an/a 79n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220850
PNG
(3-propyl-1H-pyrazole-5-carboxylic acid | 5-propyl-...)
Show SMILES CCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C7H10N2O2/c1-2-3-5-4-6(7(10)11)9-8-5/h4H,2-3H2,1H3,(H,8,9)(H,10,11)
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n/an/an/an/a 182n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
BindingDB Entry DOI: 10.7270/Q2TT4QN2
More data for this
Ligand-Target Pair