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19 similar compounds to monomer 50145143

Compile data set for download or QSAR
Wt: 371.8
BDBM50145191
Wt: 329.4
BDBM50145177
Wt: 295.3
BDBM50145187
Wt: 543.6
BDBM50145186
Wt: 396.2
BDBM50145161
Wt: 396.2
BDBM50145167
Wt: 483.3
BDBM50145170
Wt: 297.3
BDBM50145194
Wt: 283.3
BDBM50145195
Wt: 410.2
BDBM50145163
Wt: 383.2
BDBM50145164
Wt: 379.3
BDBM50145138
Wt: 362.3
BDBM50145142
Wt: 419.4
BDBM50145144
Wt: 361.3
BDBM50145148
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50145191,50145177,50145187,50145186,50145161,50145167,50145170,50145194,50145195,50145163,50145164,50145138,50145142,50145144,50145148   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50145191
PNG
(3-benzyl-6-chloro-4-methyl-2-oxo-2H-chromen-7-yl d...)
Show SMILES CN(C)C(=O)Oc1cc2oc(=O)c(Cc3ccccc3)c(C)c2cc1Cl
Show InChI InChI=1S/C20H18ClNO4/c1-12-14-10-16(21)18(26-20(24)22(2)3)11-17(14)25-19(23)15(12)9-13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibition of activated human MEK1 in MEK-ERK coupling assay


Bioorg Med Chem Lett 15: 5467-73 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.097
BindingDB Entry DOI: 10.7270/Q2HM5814
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM50145186
PNG
(CHEMBL3763900)
Show SMILES Nc1nc2cc(ccc2c(=O)n1C[C@@H]1CC[C@@H](O1)c1ccccc1)-c1ccc(CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C36H37N3O2/c37-36-38-33-24-30(28-18-16-27(17-19-28)13-7-2-6-12-26-10-4-1-5-11-26)20-22-32(33)35(40)39(36)25-31-21-23-34(41-31)29-14-8-3-9-15-29/h1,3-5,8-11,14-20,22,24,31,34H,2,6-7,12-13,21,23,25H2,(H2,37,38)/t31-,34+/m0/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of CatD (unknown origin) preincubated for 30 mins followed by DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS substrate addition by FRET assa...


J Med Chem 59: 374-87 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01558
BindingDB Entry DOI: 10.7270/Q26975DP
More data for this
Ligand-Target Pair
Interleukin-6 receptor subunit beta


(Homo sapiens (Human))
BDBM50145187
PNG
(CHEMBL3763533)
Show SMILES CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](C)[C@H](O)C1=CCCCC1
Show InChI InChI=1S/C16H25NO4/c1-10(2)13-9-21-16(20)17(13)15(19)11(3)14(18)12-7-5-4-6-8-12/h7,10-11,13-14,18H,4-6,8-9H2,1-3H3/t11-,13+,14-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...


Bioorg Med Chem Lett 26: 1282-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.016
BindingDB Entry DOI: 10.7270/Q2XD13JX
More data for this
Ligand-Target Pair
Interleukin-6 receptor subunit beta


(Homo sapiens (Human))
BDBM50145194
PNG
(CHEMBL3765178)
Show SMILES CCCCC(=C)[C@@H](O)[C@H](C)C(=O)N1[C@H](COC1=O)C(C)C
Show InChI InChI=1S/C16H27NO4/c1-6-7-8-11(4)14(18)12(5)15(19)17-13(10(2)3)9-21-16(17)20/h10,12-14,18H,4,6-9H2,1-3,5H3/t12-,13+,14+/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin E (unknown origin)


Bioorg Med Chem Lett 26: 1282-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.016
BindingDB Entry DOI: 10.7270/Q2XD13JX
More data for this
Ligand-Target Pair
Interleukin-6 receptor subunit beta


(Homo sapiens (Human))
BDBM50145195
PNG
(CHEMBL3765143)
Show SMILES CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](C)[C@H](O)C(=C)C(C)C
Show InChI InChI=1S/C15H25NO4/c1-8(2)10(5)13(17)11(6)14(18)16-12(9(3)4)7-20-15(16)19/h8-9,11-13,17H,5,7H2,1-4,6H3/t11-,12+,13+/m0/s1
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n/an/a 2.01E+4n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...


Bioorg Med Chem Lett 26: 1282-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.016
BindingDB Entry DOI: 10.7270/Q2XD13JX
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145138
PNG
(CHEMBL3764085)
Show SMILES Cn1ccnc1C1C(Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N5O/c1-27-7-6-23-19(27)16-17(10-2-4-11(21)5-3-10)24-14-9-12(22)8-13-15(14)18(16)25-26-20(13)28/h2-9,16-17,24H,1H3,(H,26,28)
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n/an/a 1.90n/an/an/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145142
PNG
(CHEMBL3765056)
Show SMILES Cn1ncnc1C1C(Nc2cccc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN6O/c1-26-18(21-9-22-26)15-16(10-5-7-11(20)8-6-10)23-13-4-2-3-12-14(13)17(15)24-25-19(12)27/h2-9,15-16,23H,1H3,(H,25,27)
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n/an/a 2.30n/an/an/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145144
PNG
(CHEMBL3764951)
Show SMILES CC(=O)Nc1ccc(cc1)C1Nc2cc(F)cc3c2c(n[nH]c3=O)C1c1ncnn1C
Show InChI InChI=1S/C21H18FN7O2/c1-10(30)25-13-5-3-11(4-6-13)18-17(20-23-9-24-29(20)2)19-16-14(21(31)28-27-19)7-12(22)8-15(16)26-18/h3-9,17-18,26H,1-2H3,(H,25,30)(H,28,31)
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n/an/a 2.10n/an/an/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145138
PNG
(CHEMBL3764085)
Show SMILES Cn1ccnc1C1C(Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N5O/c1-27-7-6-23-19(27)16-17(10-2-4-11(21)5-3-10)24-14-9-12(22)8-13-15(14)18(16)25-26-20(13)28/h2-9,16-17,24H,1H3,(H,26,28)
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n/an/an/an/a 17n/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145142
PNG
(CHEMBL3765056)
Show SMILES Cn1ncnc1C1C(Nc2cccc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN6O/c1-26-18(21-9-22-26)15-16(10-5-7-11(20)8-6-10)23-13-4-2-3-12-14(13)17(15)24-25-19(12)27/h2-9,15-16,23H,1H3,(H,25,27)
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n/an/an/an/a 6.90n/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145148
PNG
(CHEMBL3764990)
Show SMILES Cn1ccnc1[C@H]1[C@@H](Nc2cccc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H16FN5O/c1-26-10-9-22-19(26)16-17(11-5-7-12(21)8-6-11)23-14-4-2-3-13-15(14)18(16)24-25-20(13)27/h2-10,16-17,23H,1H3,(H,25,27)/t16-,17-/m0/s1
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n/an/an/an/a 285n/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50145148
PNG
(CHEMBL3764990)
Show SMILES Cn1ccnc1[C@H]1[C@@H](Nc2cccc3c2c1n[nH]c3=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H16FN5O/c1-26-10-9-22-19(26)16-17(11-5-7-12(21)8-6-11)23-14-4-2-3-13-15(14)18(16)24-25-20(13)27/h2-10,16-17,23H,1H3,(H,25,27)/t16-,17-/m0/s1
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n/an/a 136n/an/an/an/an/an/a



BioMarin Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis


J Med Chem 59: 335-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01498
BindingDB Entry DOI: 10.7270/Q2K35WJR
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145161
PNG
(CHEMBL3765545)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc3NC(=O)CCc3c2)cc1
Show InChI InChI=1S/C15H14BrN3O3S/c16-11-2-4-12(5-3-11)18-19-23(21,22)13-6-7-14-10(9-13)1-8-15(20)17-14/h2-7,9,18-19H,1,8H2,(H,17,20)
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n/an/an/an/a 67n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of Indoleamine 2,3-dioxygenase in human HeLa cells in presence of L-tryptophan as substrate after 24 hrs in presence of L-tryptophan


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145161
PNG
(CHEMBL3765545)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc3NC(=O)CCc3c2)cc1
Show InChI InChI=1S/C15H14BrN3O3S/c16-11-2-4-12(5-3-11)18-19-23(21,22)13-6-7-14-10(9-13)1-8-15(20)17-14/h2-7,9,18-19H,1,8H2,(H,17,20)
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n/an/a 73n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human Indoleamine 2,3-dioxygenase using L-tryptophan as substrate by emission fluorescence analysis


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145163
PNG
(CHEMBL3763962)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc3NC(=O)CCCc3c2)cc1
Show InChI InChI=1S/C16H16BrN3O3S/c17-12-4-6-13(7-5-12)19-20-24(22,23)14-8-9-15-11(10-14)2-1-3-16(21)18-15/h4-10,19-20H,1-3H2,(H,18,21)
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n/an/an/an/a 195n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of Indoleamine 2,3-dioxygenase in human HeLa cells in presence of L-tryptophan as substrate after 24 hrs in presence of L-tryptophan


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145163
PNG
(CHEMBL3763962)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc3NC(=O)CCCc3c2)cc1
Show InChI InChI=1S/C16H16BrN3O3S/c17-12-4-6-13(7-5-12)19-20-24(22,23)14-8-9-15-11(10-14)2-1-3-16(21)18-15/h4-10,19-20H,1-3H2,(H,18,21)
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n/an/a 112n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human Indoleamine 2,3-dioxygenase using L-tryptophan as substrate by emission fluorescence analysis


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145164
PNG
(CHEMBL3765698)
Show SMILES Oc1nc2cc(ccc2[nH]1)S(=O)(=O)NNc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN4O3S/c14-8-1-3-9(4-2-8)17-18-22(20,21)10-5-6-11-12(7-10)16-13(19)15-11/h1-7,17-18H,(H2,15,16,19)
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n/an/an/an/a 63n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of Indoleamine 2,3-dioxygenase in human HeLa cells in presence of L-tryptophan as substrate after 24 hrs in presence of L-tryptophan


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145164
PNG
(CHEMBL3765698)
Show SMILES Oc1nc2cc(ccc2[nH]1)S(=O)(=O)NNc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN4O3S/c14-8-1-3-9(4-2-8)17-18-22(20,21)10-5-6-11-12(7-10)16-13(19)15-11/h1-7,17-18H,(H2,15,16,19)
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n/an/a 57n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human Indoleamine 2,3-dioxygenase using L-tryptophan as substrate by emission fluorescence analysis


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145167
PNG
(CHEMBL3764028)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc3NC(=O)C(=O)c3c2)cc1
Show InChI InChI=1S/C14H10BrN3O4S/c15-8-1-3-9(4-2-8)17-18-23(21,22)10-5-6-12-11(7-10)13(19)14(20)16-12/h1-7,17-18H,(H,16,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human Indoleamine 2,3-dioxygenase using L-tryptophan as substrate by emission fluorescence analysis


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145170
PNG
(CHEMBL3765405)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc(NC(=O)CCN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C19H23BrN4O4S/c20-15-1-3-17(4-2-15)22-23-29(26,27)18-7-5-16(6-8-18)21-19(25)9-10-24-11-13-28-14-12-24/h1-8,22-23H,9-14H2,(H,21,25)
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n/an/a 77n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human Indoleamine 2,3-dioxygenase using L-tryptophan as substrate by emission fluorescence analysis


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM50145170
PNG
(CHEMBL3765405)
Show SMILES Brc1ccc(NNS(=O)(=O)c2ccc(NC(=O)CCN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C19H23BrN4O4S/c20-15-1-3-17(4-2-15)22-23-29(26,27)18-7-5-16(6-8-18)21-19(25)9-10-24-11-13-28-14-12-24/h1-8,22-23H,9-14H2,(H,21,25)
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n/an/an/an/a 217n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of Indoleamine 2,3-dioxygenase in human HeLa cells in presence of L-tryptophan as substrate after 24 hrs in presence of L-tryptophan


J Med Chem 59: 419-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01640
BindingDB Entry DOI: 10.7270/Q2FF3V69
More data for this
Ligand-Target Pair
Plasmepsin 2


(Plasmodium falciparum)
BDBM50145186
PNG
(CHEMBL3763900)
Show SMILES Nc1nc2cc(ccc2c(=O)n1C[C@@H]1CC[C@@H](O1)c1ccccc1)-c1ccc(CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C36H37N3O2/c37-36-38-33-24-30(28-18-16-27(17-19-28)13-7-2-6-12-26-10-4-1-5-11-26)20-22-32(33)35(40)39(36)25-31-21-23-34(41-31)29-14-8-3-9-15-29/h1,3-5,8-11,14-20,22,24,31,34H,2,6-7,12-13,21,23,25H2,(H2,37,38)/t31-,34+/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of pepstatin A from recombinant Plasmodium falciparum plasmepsin 2 by NMR analysis


J Med Chem 59: 374-87 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01558
BindingDB Entry DOI: 10.7270/Q26975DP
More data for this
Ligand-Target Pair
Plasmepsin I


(Plasmodium falciparum)
BDBM50145186
PNG
(CHEMBL3763900)
Show SMILES Nc1nc2cc(ccc2c(=O)n1C[C@@H]1CC[C@@H](O1)c1ccccc1)-c1ccc(CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C36H37N3O2/c37-36-38-33-24-30(28-18-16-27(17-19-28)13-7-2-6-12-26-10-4-1-5-11-26)20-22-32(33)35(40)39(36)25-31-21-23-34(41-31)29-14-8-3-9-15-29/h1,3-5,8-11,14-20,22,24,31,34H,2,6-7,12-13,21,23,25H2,(H2,37,38)/t31-,34+/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 1 preincubated for 30 mins followed by DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS substrate addition...


J Med Chem 59: 374-87 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01558
BindingDB Entry DOI: 10.7270/Q26975DP
More data for this
Ligand-Target Pair
Interleukin-6 receptor subunit beta


(Homo sapiens (Human))
BDBM50145177
PNG
(CHEMBL3764956)
Show SMILES CCCCCC(=C)[C@@H](O)[C@H](C)Cn1cc(CCO)c2ccccc12
Show InChI InChI=1S/C21H31NO2/c1-4-5-6-9-16(2)21(24)17(3)14-22-15-18(12-13-23)19-10-7-8-11-20(19)22/h7-8,10-11,15,17,21,23-24H,2,4-6,9,12-14H2,1,3H3/t17-,21-/m1/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...


Bioorg Med Chem Lett 26: 1282-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.016
BindingDB Entry DOI: 10.7270/Q2XD13JX
More data for this
Ligand-Target Pair