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15 similar compounds to monomer 50145972

Wt: 535.6
BDBM50145962
Wt: 466.5
BDBM50145963
Wt: 465.5
BDBM50145964
Wt: 435.5
BDBM50145968
Wt: 464.5
BDBM50145969
Wt: 479.5
BDBM50145970
Wt: 451.5
BDBM50145971
Wt: 450.5
BDBM50145973
Wt: 386.4
BDBM50145975
Wt: 479.5
BDBM50145976
Wt: 484.9
BDBM50145977
Wt: 493.5
BDBM50145978
Wt: 464.5
BDBM50145981
Wt: 385.4
BDBM50145987
Wt: 436.5
BDBM50145988

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50145962,50145963,50145964,50145968,50145969,50145970,50145971,50145973,50145975,50145976,50145977,50145978,50145981,50145987,50145988   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50145987
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H23N3O2/c1-4-21-26-22-15(2)13-16(3)25-23(22)27(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)24(28)29/h5-13H,4,14H2,1-3H3,(H,28,29)
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n/an/a 3.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of the specific binding ligand [125I]-Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.


Bioorg Med Chem Lett 4: 41-44 (1994)

More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50145981
PNG
(4-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyri...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(C)nc2ccccc12
Show InChI InChI=1S/C29H28N4O2/c1-5-8-24-32-27-17(2)15-18(3)30-28(27)33(24)16-20-11-13-21(14-12-20)26-22-9-6-7-10-23(22)31-19(4)25(26)29(34)35/h6-7,9-15H,5,8,16H2,1-4H3,(H,34,35)
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n/an/a 13n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabit aortic strip contraction


J Med Chem 49: 6451-64 (2006)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145962
PNG
(2-Dipropylamino-4-[4-(2-ethyl-5,7-dimethyl-imidazo...)
Show SMILES CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc34)cc2)c1C(O)=O
Show InChI InChI=1S/C33H37N5O2/c1-6-17-37(18-7-2)31-29(33(39)40)28(25-11-9-10-12-26(25)35-31)24-15-13-23(14-16-24)20-38-27(8-3)36-30-21(4)19-22(5)34-32(30)38/h9-16,19H,6-8,17-18,20H2,1-5H3,(H,39,40)
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Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145964
PNG
(4-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(NC)nc2ccccc12
Show InChI InChI=1S/C28H27N5O2/c1-5-22-32-25-16(2)14-17(3)30-27(25)33(22)15-18-10-12-19(13-11-18)23-20-8-6-7-9-21(20)31-26(29-4)24(23)28(34)35/h6-14H,5,15H2,1-4H3,(H,29,31)(H,34,35)
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Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145968
PNG
(1-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(ccc2ccccc12)C(O)=O
Show InChI InChI=1S/C28H25N3O2/c1-4-24-30-26-17(2)15-18(3)29-27(26)31(24)16-19-9-11-21(12-10-19)25-22-8-6-5-7-20(22)13-14-23(25)28(32)33/h5-15H,4,16H2,1-3H3,(H,32,33)
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n/an/a 33n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145970
PNG
(2-Dimethylamino-4-[4-(2-ethyl-5,7-dimethyl-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(nc2ccccc12)N(C)C
Show InChI InChI=1S/C29H29N5O2/c1-6-23-32-26-17(2)15-18(3)30-28(26)34(23)16-19-11-13-20(14-12-19)24-21-9-7-8-10-22(21)31-27(33(4)5)25(24)29(35)36/h7-15H,6,16H2,1-5H3,(H,35,36)
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n/an/a 29n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145971
PNG
(2-Amino-4-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]p...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(N)nc2ccccc12
Show InChI InChI=1S/C27H25N5O2/c1-4-21-31-24-15(2)13-16(3)29-26(24)32(21)14-17-9-11-18(12-10-17)22-19-7-5-6-8-20(19)30-25(28)23(22)27(33)34/h5-13H,4,14H2,1-3H3,(H2,28,30)(H,33,34)
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n/an/a 13n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145969
PNG
(4-[4-(2-Butyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)C(O)=O
Show InChI InChI=1S/C29H28N4O2/c1-4-5-10-25-32-27-18(2)15-19(3)31-28(27)33(25)17-20-11-13-21(14-12-20)26-22-8-6-7-9-24(22)30-16-23(26)29(34)35/h6-9,11-16H,4-5,10,17H2,1-3H3,(H,34,35)
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n/an/a 41n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145973
PNG
(4-[4-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)C(O)=O
Show InChI InChI=1S/C28H26N4O2/c1-4-7-24-31-26-17(2)14-18(3)30-27(26)32(24)16-19-10-12-20(13-11-19)25-21-8-5-6-9-23(21)29-15-22(25)28(33)34/h5-6,8-15H,4,7,16H2,1-3H3,(H,33,34)
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n/an/a 11n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145975
PNG
(2-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ncccc1C(O)=O
Show InChI InChI=1S/C23H22N4O2/c1-4-19-26-20-14(2)12-15(3)25-22(20)27(19)13-16-7-9-17(10-8-16)21-18(23(28)29)6-5-11-24-21/h5-12H,4,13H2,1-3H3,(H,28,29)
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n/an/a 819n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145976
PNG
(2-Amino-4-[4-(2-butyl-5,7-dimethyl-imidazo[4,5-b]p...)
Show SMILES CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(N)nc2ccccc12
Show InChI InChI=1S/C29H29N5O2/c1-4-5-10-23-33-26-17(2)15-18(3)31-28(26)34(23)16-19-11-13-20(14-12-19)24-21-8-6-7-9-22(21)32-27(30)25(24)29(35)36/h6-9,11-15H,4-5,10,16H2,1-3H3,(H2,30,32)(H,35,36)
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n/an/a 13n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145977
PNG
(2-Chloro-4-[4-(5,7-dimethyl-2-propyl-imidazo[4,5-b...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(Cl)nc2ccccc12
Show InChI InChI=1S/C28H25ClN4O2/c1-4-7-22-32-25-16(2)14-17(3)30-27(25)33(22)15-18-10-12-19(13-11-18)23-20-8-5-6-9-21(20)31-26(29)24(23)28(34)35/h5-6,8-14H,4,7,15H2,1-3H3,(H,34,35)
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n/an/a 7.70n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145978
PNG
(4-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc34)cc2)c1C(O)=O
Show InChI InChI=1S/C30H31N5O2/c1-5-15-31-28-26(30(36)37)25(22-9-7-8-10-23(22)33-28)21-13-11-20(12-14-21)17-35-24(6-2)34-27-18(3)16-19(4)32-29(27)35/h7-14,16H,5-6,15,17H2,1-4H3,(H,31,33)(H,36,37)
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n/an/a 66n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145981
PNG
(4-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyri...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(C)nc2ccccc12
Show InChI InChI=1S/C29H28N4O2/c1-5-8-24-32-27-17(2)15-18(3)30-28(27)33(24)16-20-11-13-21(14-12-20)26-22-9-6-7-10-23(22)31-19(4)25(26)29(34)35/h6-7,9-15H,5,8,16H2,1-4H3,(H,34,35)
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n/an/a 9n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145988
PNG
(4-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)C(O)=O
Show InChI InChI=1S/C27H24N4O2/c1-4-23-30-25-16(2)13-17(3)29-26(25)31(23)15-18-9-11-19(12-10-18)24-20-7-5-6-8-22(20)28-14-21(24)27(32)33/h5-14H,4,15H2,1-3H3,(H,32,33)
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n/an/a 17n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145987
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H23N3O2/c1-4-21-26-22-15(2)13-16(3)25-23(22)27(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)24(28)29/h5-13H,4,14H2,1-3H3,(H,28,29)
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n/an/a 10n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50145963
PNG
(4-[4-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(C(O)=O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C28H26N4O3/c1-4-7-22-31-25-16(2)14-17(3)29-26(25)32(22)15-18-10-12-19(13-11-18)23-20-8-5-6-9-21(20)30-27(33)24(23)28(34)35/h5-6,8-14H,4,7,15H2,1-3H3,(H,30,33)(H,34,35)
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n/an/a 261n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity for rat angiotensin II receptor, type 1


J Med Chem 47: 2574-86 (2004)

More data for this
Ligand-Target Pair