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15 similar compounds to monomer 50146972

Wt: 309.8
BDBM50146961
Wt: 309.8
BDBM50146971
Wt: 327.8
BDBM50146974
Wt: 275.3
BDBM50146975
Wt: 325.8
BDBM50146976
Wt: 323.8
BDBM50146979
Wt: 434.4
BDBM50146982
Wt: 323.8
BDBM50146986
Wt: 323.8
BDBM50146987
Wt: 325.8
BDBM50146949
Wt: 323.8
BDBM50146950
Wt: 323.8
BDBM50146956
Wt: 323.8
BDBM50191166
Wt: 323.8
BDBM50191168
Wt: 337.8
BDBM50191170

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50146961,50146971,50146974,50146975,50146976,50146979,50146982,50146986,50146987,50146949,50146950,50146956,50191166,50191168,50191170   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146949
PNG
(2-(S)-Amino-4-(4-chloro-benzylamino)-1-(4-hydroxy-...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C16H24ClN3O2/c17-13-3-1-12(2-4-13)11-19-8-5-15(18)16(22)20-9-6-14(21)7-10-20/h1-4,14-15,19,21H,5-11,18H2/t15-/m0/s1
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n/an/a 113n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP4 expressed in insect cells


J Med Chem 53: 6572-83 (2010)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146956
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-methyl-p...)
Show SMILES CC1CCN(CC1)C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-7-10-21(11-8-13)17(22)16(19)6-9-20-12-14-2-4-15(18)5-3-14/h2-5,13,16,20H,6-12,19H2,1H3/t16-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146961
PNG
(2-(S)-Amino-4-(3-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1cccc(Cl)c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-6-4-5-13(11-14)12-19-8-7-15(18)16(21)20-9-2-1-3-10-20/h4-6,11,15,19H,1-3,7-10,12,18H2/t15-/m0/s1
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n/an/a 1.34n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146950
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3-methyl-p...)
Show SMILES CC1CCCN(C1)C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-3-2-10-21(12-13)17(22)16(19)8-9-20-11-14-4-6-15(18)7-5-14/h4-7,13,16,20H,2-3,8-12,19H2,1H3/t13?,16-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a 3.45E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146949
PNG
(2-(S)-Amino-4-(4-chloro-benzylamino)-1-(4-hydroxy-...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C16H24ClN3O2/c17-13-3-1-12(2-4-13)11-19-8-5-15(18)16(22)20-9-6-14(21)7-10-20/h1-4,14-15,19,21H,5-11,18H2/t15-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146974
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-fluoro-p...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCC(F)CC1
Show InChI InChI=1S/C16H23ClFN3O/c17-13-3-1-12(2-4-13)11-20-8-5-15(19)16(22)21-9-6-14(18)7-10-21/h1-4,14-15,20H,5-11,19H2/t15-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146975
PNG
(2-(S)-Amino-4-benzylamino-1-piperidin-1-yl-butan-1...)
Show SMILES N[C@@H](CCNCc1ccccc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H25N3O/c17-15(16(20)19-11-5-2-6-12-19)9-10-18-13-14-7-3-1-4-8-14/h1,3-4,7-8,15,18H,2,5-6,9-13,17H2/t15-/m0/s1
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n/an/a 2.03n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146976
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3-hydroxy-...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C16H24ClN3O2/c17-13-5-3-12(4-6-13)10-19-8-7-15(18)16(22)20-9-1-2-14(21)11-20/h3-6,14-15,19,21H,1-2,7-11,18H2/t14?,15-/m0/s1
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n/an/a 54.7n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146979
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(2-methyl-p...)
Show SMILES CC1CCCCN1C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-4-2-3-11-21(13)17(22)16(19)9-10-20-12-14-5-7-15(18)8-6-14/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13?,16-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146982
PNG
((S)-2-Amino-4-[bis-(4-chloro-benzyl)-amino]-1-pipe...)
Show SMILES N[C@@H](CCN(Cc1ccc(Cl)cc1)Cc1ccc(Cl)cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C23H29Cl2N3O/c24-20-8-4-18(5-9-20)16-27(17-19-6-10-21(25)11-7-19)15-12-22(26)23(29)28-13-2-1-3-14-28/h4-11,22H,1-3,12-17,26H2/t22-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146956
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-methyl-p...)
Show SMILES CC1CCN(CC1)C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-7-10-21(11-8-13)17(22)16(19)6-9-20-12-14-2-4-15(18)5-3-14/h2-5,13,16,20H,6-12,19H2,1H3/t16-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146986
PNG
((S)-4-(4-Chloro-benzylamino)-2-methylamino-1-piper...)
Show SMILES CN[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H26ClN3O/c1-19-16(17(22)21-11-3-2-4-12-21)9-10-20-13-14-5-7-15(18)8-6-14/h5-8,16,19-20H,2-4,9-13H2,1H3/t16-/m0/s1
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n/an/a 187n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146982
PNG
((S)-2-Amino-4-[bis-(4-chloro-benzyl)-amino]-1-pipe...)
Show SMILES N[C@@H](CCN(Cc1ccc(Cl)cc1)Cc1ccc(Cl)cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C23H29Cl2N3O/c24-20-8-4-18(5-9-20)16-27(17-19-6-10-21(25)11-7-19)15-12-22(26)23(29)28-13-2-1-3-14-28/h4-11,22H,1-3,12-17,26H2/t22-/m0/s1
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n/an/a>1.25E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146987
PNG
((S)-2-Amino-4-[(4-chloro-benzyl)-methyl-amino]-1-p...)
Show SMILES CN(CC[C@H](N)C(=O)N1CCCCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-20(13-14-5-7-15(18)8-6-14)12-9-16(19)17(22)21-10-3-2-4-11-21/h5-8,16H,2-4,9-13,19H2,1H3/t16-/m0/s1
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n/an/a 0.220n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146979
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(2-methyl-p...)
Show SMILES CC1CCCCN1C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-4-2-3-11-21(13)17(22)16(19)9-10-20-12-14-5-7-15(18)8-6-14/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13?,16-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146974
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-fluoro-p...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCC(F)CC1
Show InChI InChI=1S/C16H23ClFN3O/c17-13-3-1-12(2-4-13)11-20-8-5-15(19)16(22)21-9-6-14(18)7-10-21/h1-4,14-15,20H,5-11,19H2/t15-/m0/s1
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n/an/a 7.00E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146961
PNG
(2-(S)-Amino-4-(3-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1cccc(Cl)c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-6-4-5-13(11-14)12-19-8-7-15(18)16(21)20-9-2-1-3-10-20/h4-6,11,15,19H,1-3,7-10,12,18H2/t15-/m0/s1
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n/an/a 1.86E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a 0.230n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146987
PNG
((S)-2-Amino-4-[(4-chloro-benzyl)-methyl-amino]-1-p...)
Show SMILES CN(CC[C@H](N)C(=O)N1CCCCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-20(13-14-5-7-15(18)8-6-14)12-9-16(19)17(22)21-10-3-2-4-11-21/h5-8,16H,2-4,9-13,19H2,1H3/t16-/m0/s1
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n/an/a 1.96E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146976
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3-hydroxy-...)
Show SMILES N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C16H24ClN3O2/c17-13-5-3-12(4-6-13)10-19-8-7-15(18)16(22)20-9-1-2-14(21)11-20/h3-6,14-15,19,21H,1-2,7-11,18H2/t14?,15-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146975
PNG
(2-(S)-Amino-4-benzylamino-1-piperidin-1-yl-butan-1...)
Show SMILES N[C@@H](CCNCc1ccccc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H25N3O/c17-15(16(20)19-11-5-2-6-12-19)9-10-18-13-14-7-3-1-4-8-14/h1,3-4,7-8,15,18H,2,5-6,9-13,17H2/t15-/m0/s1
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n/an/a 2.47E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50146986
PNG
((S)-4-(4-Chloro-benzylamino)-2-methylamino-1-piper...)
Show SMILES CN[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H26ClN3O/c1-19-16(17(22)21-11-3-2-4-12-21)9-10-20-13-14-5-7-15(18)8-6-14/h5-8,16,19-20H,2-4,9-13H2,1H3/t16-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase IV (DPP IV)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50191166
PNG
((2S,4R)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50191168
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50191168
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16-/m0/s1
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n/an/a 1.48E+5n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50191170
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES CC[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C18H28ClN3O/c1-2-16(21-13-14-6-8-15(19)9-7-14)12-17(20)18(23)22-10-4-3-5-11-22/h6-9,16-17,21H,2-5,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50191170
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES CC[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C18H28ClN3O/c1-2-16(21-13-14-6-8-15(19)9-7-14)12-17(20)18(23)22-10-4-3-5-11-22/h6-9,16-17,21H,2-5,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50191166
PNG
((2S,4R)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16+/m1/s1
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n/an/a>2.50E+5n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50191168
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16-/m0/s1
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n/an/a 3.25E+5n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50191170
PNG
((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES CC[C@@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C18H28ClN3O/c1-2-16(21-13-14-6-8-15(19)9-7-14)12-17(20)18(23)22-10-4-3-5-11-22/h6-9,16-17,21H,2-5,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50191166
PNG
((2S,4R)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Show SMILES C[C@H](C[C@H](N)C(=O)N1CCCCC1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13(20-12-14-5-7-15(18)8-6-14)11-16(19)17(22)21-9-3-2-4-10-21/h5-8,13,16,20H,2-4,9-12,19H2,1H3/t13-,16+/m1/s1
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n/an/a 6.50E+4n/an/an/an/an/an/a



Laboratory of Medicinal Chemistry University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8


Bioorg Med Chem Lett 16: 4777-9 (2006)

More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAP expressed in Hi5 insect cells


J Med Chem 53: 6572-83 (2010)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP8 expressed in insect cells


J Med Chem 53: 6572-83 (2010)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP9 expressed in insect cells


J Med Chem 53: 6572-83 (2010)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146971
PNG
(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Show SMILES N[C@@H](CCNCc1ccccc1Cl)C(=O)N1CCCCC1
Show InChI InChI=1S/C16H24ClN3O/c17-14-7-3-2-6-13(14)12-19-9-8-15(18)16(21)20-10-4-1-5-11-20/h2-3,6-7,15,19H,1,4-5,8-12,18H2/t15-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP2 expressed in insect cells


J Med Chem 53: 6572-83 (2010)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50146950
PNG
((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3-methyl-p...)
Show SMILES CC1CCCN(C1)C(=O)[C@@H](N)CCNCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H26ClN3O/c1-13-3-2-10-21(12-13)17(22)16(19)8-9-20-11-14-4-6-15(18)7-5-14/h4-7,13,16,20H,2-3,8-12,19H2,1H3/t13?,16-/m0/s1
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n/an/a 1.13n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human Dipeptidyl-peptidase II (DPP II)


J Med Chem 47: 2906-16 (2004)

More data for this
Ligand-Target Pair