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15 similar compounds to monomer 50147150

Compile data set for download or QSAR
Wt: 388.4
BDBM50147125
Wt: 416.4
BDBM50147126
Wt: 414.3
BDBM50147130
Wt: 416.4
BDBM50147132
Wt: 360.3
BDBM50147134
Wt: 402.4
BDBM50147137
Wt: 402.4
BDBM50147139
Wt: 416.4
BDBM50147143
Wt: 432.4
BDBM50147146
Wt: 460.4
BDBM50147151
Wt: 446.4
BDBM50147153
Wt: 428.4
BDBM50147154
Wt: 428.3
BDBM50147155
Wt: 414.4
BDBM50147156
Wt: 436.4
BDBM50147157

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50147125,50147126,50147130,50147132,50147134,50147137,50147139,50147143,50147146,50147151,50147153,50147154,50147155,50147156,50147157   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147125
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-isopropoxy-...)
Show SMILES CC(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C17H19F3N2O3S/c1-13(2)25-16-7-3-6-15(9-16)22(11-14-5-4-8-21-10-14)26(23,24)12-17(18,19)20/h3-10,13H,11-12H2,1-2H3
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n/an/an/an/a 32n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147143
PNG
(2,2,2-Trifluoro-ethanesulfonic acid [3-(1-methyl-b...)
Show SMILES CCCC(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1/C19H23F3N2O3S/c1-3-6-15(2)27-18-9-4-8-17(11-18)24(13-16-7-5-10-23-12-16)28(25,26)14-19(20,21)22/h4-5,7-12,15H,3,6,13-14H2,1-2H3
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n/an/an/an/a 30.9n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 20: 175-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.008
BindingDB Entry DOI: 10.7270/Q2W95BD6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147130
PNG
(2,2,2-Trifluoro-ethanesulfonic acid pyridin-3-ylme...)
Show SMILES FC(F)(F)CS(=O)(=O)N(Cc1cccnc1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C15H12F6N2O3S/c16-14(17,18)10-27(24,25)23(9-11-3-2-6-22-8-11)12-4-1-5-13(7-12)26-15(19,20)21/h1-8H,9-10H2
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n/an/an/an/a 140n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147132
PNG
(2,2,2-Trifluoro-ethanesulfonic acid [3-(2-methyl-b...)
Show SMILES CCC(C)COc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1/C19H23F3N2O3S/c1-3-15(2)13-27-18-8-4-7-17(10-18)24(12-16-6-5-9-23-11-16)28(25,26)14-19(20,21)22/h4-11,15H,3,12-14H2,1-2H3
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n/an/an/an/a 17n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147134
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-methoxy-phe...)
Show SMILES COc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C15H15F3N2O3S/c1-23-14-6-2-5-13(8-14)20(10-12-4-3-7-19-9-12)24(21,22)11-15(16,17)18/h2-9H,10-11H2,1H3
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n/an/an/an/a 2.10E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147137
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-sec-butoxy-...)
Show SMILES CCC(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1/C18H21F3N2O3S/c1-3-14(2)26-17-8-4-7-16(10-17)23(12-15-6-5-9-22-11-15)27(24,25)13-18(19,20)21/h4-11,14H,3,12-13H2,1-2H3
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n/an/an/an/a 18n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147139
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-isobutoxy-p...)
Show SMILES CC(C)COc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C18H21F3N2O3S/c1-14(2)12-26-17-7-3-6-16(9-17)23(11-15-5-4-8-22-10-15)27(24,25)13-18(19,20)21/h3-10,14H,11-13H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147143
PNG
(2,2,2-Trifluoro-ethanesulfonic acid [3-(1-methyl-b...)
Show SMILES CCCC(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1/C19H23F3N2O3S/c1-3-6-15(2)27-18-9-4-8-17(11-18)24(13-16-7-5-10-23-12-16)28(25,26)14-19(20,21)22/h4-5,7-12,15H,3,6,13-14H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147146
PNG
(CHEMBL440328 | {3-[Pyridin-3-ylmethyl-(trifluoro-e...)
Show SMILES CCOC(=O)COc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C18H19F3N2O5S/c1-2-27-17(24)12-28-16-7-3-6-15(9-16)23(11-14-5-4-8-22-10-14)29(25,26)13-18(19,20)21/h3-10H,2,11-13H2,1H3
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n/an/an/an/a 640n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147151
PNG
(2-Methyl-2-{3-[pyridin-3-ylmethyl-(2,2,2-trifluoro...)
Show SMILES CCOC(=O)C(C)(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C20H23F3N2O5S/c1-4-29-18(26)19(2,3)30-17-9-5-8-16(11-17)25(13-15-7-6-10-24-12-15)31(27,28)14-20(21,22)23/h5-12H,4,13-14H2,1-3H3
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n/an/an/an/a 88n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147153
PNG
(2-{3-[Pyridin-3-ylmethyl-(2,2,2-trifluoro-ethanesu...)
Show SMILES CCOC(=O)C(C)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1/C19H21F3N2O5S/c1-3-28-18(25)14(2)29-17-8-4-7-16(10-17)24(12-15-6-5-9-23-11-15)30(26,27)13-19(20,21)22/h4-11,14H,3,12-13H2,1-2H3
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n/an/an/an/a 230n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147157
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-benzyloxy-p...)
Show SMILES FC(F)(F)CS(=O)(=O)N(Cc1cccnc1)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C21H19F3N2O3S/c22-21(23,24)16-30(27,28)26(14-18-8-5-11-25-13-18)19-9-4-10-20(12-19)29-15-17-6-2-1-3-7-17/h1-13H,14-16H2
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n/an/an/an/a 620n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147156
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-cyclopentyl...)
Show SMILES FC(F)(F)CS(=O)(=O)N(Cc1cccnc1)c1cccc(OC2CCCC2)c1
Show InChI InChI=1S/C19H21F3N2O3S/c20-19(21,22)14-28(25,26)24(13-15-5-4-10-23-12-15)16-6-3-9-18(11-16)27-17-7-1-2-8-17/h3-6,9-12,17H,1-2,7-8,13-14H2
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n/an/an/an/a 24n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147154
PNG
(2,2,2-Trifluoro-ethanesulfonic acid (3-cyclohexylo...)
Show SMILES FC(F)(F)CS(=O)(=O)N(Cc1cccnc1)c1cccc(OC2CCCCC2)c1
Show InChI InChI=1S/C20H23F3N2O3S/c21-20(22,23)15-29(26,27)25(14-16-6-5-11-24-13-16)17-7-4-10-19(12-17)28-18-8-2-1-3-9-18/h4-7,10-13,18H,1-3,8-9,14-15H2
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n/an/an/an/a 29n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147155
PNG
(2,2,2-Trifluoro-ethanesulfonic acid pyridin-3-ylme...)
Show SMILES FC(F)(F)COc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C16H14F6N2O3S/c17-15(18,19)10-27-14-5-1-4-13(7-14)24(9-12-3-2-6-23-8-12)28(25,26)11-16(20,21)22/h1-8H,9-11H2
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n/an/an/an/a 100n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50147126
PNG
(2,2,2-Trifluoro-ethanesulfonic acid [3-(1-ethyl-pr...)
Show SMILES CCC(CC)Oc1cccc(c1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C19H23F3N2O3S/c1-3-17(4-2)27-18-9-5-8-16(11-18)24(13-15-7-6-10-23-12-15)28(25,26)14-19(20,21)22/h5-12,17H,3-4,13-14H2,1-2H3
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n/an/an/an/a 16n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 14: 3099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.017
BindingDB Entry DOI: 10.7270/Q2222T69
More data for this
Ligand-Target Pair