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2 similar compounds to monomer 50149698

Compile data set for download or QSAR
Wt: 444.3
BDBM50149703
Wt: 338.4
BDBM50149699

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50149703,50149699   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149703
PNG
(CHEMBL3770438)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)nc3n(ncc23)C2CCCC2)c(=O)[nH]1
Show InChI InChI=1S/C20H22BrN5O2/c1-11-7-12(2)24-20(28)15(11)9-22-19(27)14-8-17(21)25-18-16(14)10-23-26(18)13-5-3-4-6-13/h7-8,10,13H,3-6,9H2,1-2H3,(H,22,27)(H,24,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Epizyme

Curated by ChEMBL


Assay Description
Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay


J Med Chem 59: 1556-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01501
BindingDB Entry DOI: 10.7270/Q2B56MM7
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149699
PNG
(CHEMBL3770275)
Show SMILES CC(C)n1cnc2c(cccc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H22N4O2/c1-11(2)23-10-21-17-14(6-5-7-16(17)23)18(24)20-9-15-12(3)8-13(4)22-19(15)25/h5-8,10-11H,9H2,1-4H3,(H,20,24)(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Epizyme

Curated by ChEMBL


Assay Description
Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay


J Med Chem 59: 1556-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01501
BindingDB Entry DOI: 10.7270/Q2B56MM7
More data for this
Ligand-Target Pair