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33 similar compounds to monomer 50154995

Compile data set for download or QSAR
Wt: 266.2
BDBM50151910
Wt: 318.3
BDBM50154981
Wt: 332.3
BDBM50154982
Wt: 318.3
BDBM50154983
Wt: 332.3
BDBM50154984
Wt: 342.3
BDBM50154985
Wt: 332.3
BDBM50154986
Wt: 342.3
BDBM50154987
Wt: 332.3
BDBM50154988
Wt: 317.3
BDBM50154989
Wt: 333.3
BDBM50154990
Wt: 332.3
BDBM50154992
Wt: 331.3
BDBM50154993
Wt: 331.3
BDBM50154994
Wt: 333.3
BDBM50154996
Displayed 1 to 15 (of 33 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 50151910,50154981,50154982,50154983,50154984,50154985,50154986,50154987,50154988,50154989,50154990,50154992,50154993,50154994,50154996   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154987
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1C#N
Show InChI InChI=1S/C19H11FN6/c20-15-9-14(17-6-2-1-5-13(17)12-21)10-16(11-15)26-24-19(23-25-26)18-7-3-4-8-22-18/h1-11H
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4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154988
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Nc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c19-13-9-12(15-5-1-2-6-16(15)20)10-14(11-13)25-23-18(22-24-25)17-7-3-4-8-21-17/h1-11H,20H2
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7n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from glutamate 5 receptor of rat cortical membranes


J Med Chem 47: 4645-8 (2004)


Article DOI: 10.1021/jm049828c
BindingDB Entry DOI: 10.7270/Q2DJ5F3G
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154985
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C19H11FN6/c20-16-9-15(14-5-3-4-13(8-14)12-21)10-17(11-16)26-24-19(23-25-26)18-6-1-2-7-22-18/h1-11H
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12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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14n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5473-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.012
BindingDB Entry DOI: 10.7270/Q2F47NMM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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14n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes


Bioorg Med Chem Lett 15: 5061-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.062
BindingDB Entry DOI: 10.7270/Q2GT5MQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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14n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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14n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5481-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.018
BindingDB Entry DOI: 10.7270/Q25M657V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154990
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Nc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C17H12FN7/c18-12-7-11(14-10-20-6-4-15(14)19)8-13(9-12)25-23-17(22-24-25)16-3-1-2-5-21-16/h1-10H,(H2,19,20)
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20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154993
PNG
(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Show SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C19H14FN5/c1-13-6-2-3-7-17(13)14-10-15(20)12-16(11-14)25-23-19(22-24-25)18-8-4-5-9-21-18/h2-12H,1H3
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23n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154996
PNG
(2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Nc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C17H12FN7/c18-12-8-11(16-14(19)4-3-7-21-16)9-13(10-12)25-23-17(22-24-25)15-5-1-2-6-20-15/h1-10H,19H2
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31n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154986
PNG
(4-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1cnccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-11-20-7-5-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3
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33n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154992
PNG
(5-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1ccc(cn1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-5-6-13(11-21-12)14-8-15(19)10-16(9-14)25-23-18(22-24-25)17-4-2-3-7-20-17/h2-11H,1H3
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36n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154981
PNG
(2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H
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37n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes


Bioorg Med Chem Lett 15: 5061-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.062
BindingDB Entry DOI: 10.7270/Q2GT5MQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154981
PNG
(2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H
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37n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154984
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1ncccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-16(5-4-8-20-12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)17-6-2-3-7-21-17/h2-11H,1H3
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45n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154989
PNG
(2-[2-(5-Fluoro-biphenyl-3-yl)-2H-tetrazol-5-yl]-py...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C18H12FN5/c19-15-10-14(13-6-2-1-3-7-13)11-16(12-15)24-22-18(21-23-24)17-8-4-5-9-20-17/h1-12H
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53n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154983
PNG
(2-[2-(3-fluoro-5-pyridin-2-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C17H11FN6/c18-13-9-12(15-5-1-3-7-19-15)10-14(11-13)24-22-17(21-23-24)16-6-2-4-8-20-16/h1-11H
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95n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154982
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1cncc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-6-14(11-20-10-12)13-7-15(19)9-16(8-13)25-23-18(22-24-25)17-4-2-3-5-21-17/h2-11H,1H3
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272n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154994
PNG
(2-[2-(5-Fluoro-3''-methyl-biphenyl-3-yl)-2H-tetraz...)
Show SMILES Cc1cccc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C19H14FN5/c1-13-5-4-6-14(9-13)15-10-16(20)12-17(11-15)25-23-19(22-24-25)18-7-2-3-8-21-18/h2-12H,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay


Bioorg Med Chem Lett 14: 5485-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.016
BindingDB Entry DOI: 10.7270/Q21V5DGP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154989
PNG
(2-[2-(5-Fluoro-biphenyl-3-yl)-2H-tetrazol-5-yl]-py...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C18H12FN5/c19-15-10-14(13-6-2-1-3-7-13)11-16(12-15)24-22-18(21-23-24)17-8-4-5-9-20-17/h1-12H
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n/an/a 247n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay


Bioorg Med Chem Lett 14: 5485-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.016
BindingDB Entry DOI: 10.7270/Q21V5DGP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5


Bioorg Med Chem Lett 15: 5061-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.062
BindingDB Entry DOI: 10.7270/Q2GT5MQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154993
PNG
(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Show SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C19H14FN5/c1-13-6-2-3-7-17(13)14-10-15(20)12-16(11-14)25-23-19(22-24-25)18-8-4-5-9-21-18/h2-12H,1H3
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n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay


Bioorg Med Chem Lett 14: 5485-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.016
BindingDB Entry DOI: 10.7270/Q21V5DGP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154981
PNG
(2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H
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n/an/a 54n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay


Bioorg Med Chem Lett 14: 5485-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.016
BindingDB Entry DOI: 10.7270/Q21V5DGP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154983
PNG
(2-[2-(3-fluoro-5-pyridin-2-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C17H11FN6/c18-13-9-12(15-5-1-3-7-19-15)10-14(11-13)24-22-17(21-23-24)16-6-2-4-8-20-16/h1-11H
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n/an/a 39n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154990
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Nc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C17H12FN7/c18-12-7-11(14-10-20-6-4-15(14)19)8-13(9-12)25-23-17(22-24-25)16-3-1-2-5-21-16/h1-10H,(H2,19,20)
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n/an/a 108n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154993
PNG
(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Show SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C19H14FN5/c1-13-6-2-3-7-17(13)14-10-15(20)12-16(11-14)25-23-19(22-24-25)18-8-4-5-9-21-18/h2-12H,1H3
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n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154982
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1cncc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-6-14(11-20-10-12)13-7-15(19)9-16(8-13)25-23-18(22-24-25)17-4-2-3-5-21-17/h2-11H,1H3
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n/an/a 499n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154988
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Nc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c19-13-9-12(15-5-1-2-6-16(15)20)10-14(11-13)25-23-18(22-24-25)17-7-3-4-8-21-17/h1-11H,20H2
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154987
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1C#N
Show InChI InChI=1S/C19H11FN6/c20-15-9-14(17-6-2-1-5-13(17)12-21)10-16(11-15)26-24-19(23-25-26)18-7-3-4-8-22-18/h1-11H
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154996
PNG
(2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Nc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C17H12FN7/c18-12-8-11(16-14(19)4-3-7-21-16)9-13(10-12)25-23-17(22-24-25)15-5-1-2-6-20-15/h1-10H,19H2
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154994
PNG
(2-[2-(5-Fluoro-3''-methyl-biphenyl-3-yl)-2H-tetraz...)
Show SMILES Cc1cccc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C19H14FN5/c1-13-5-4-6-14(9-13)15-10-16(20)12-17(11-15)25-23-19(22-24-25)18-7-2-3-8-21-18/h2-12H,1H3
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n/an/a 1.47E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154992
PNG
(5-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1ccc(cn1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-5-6-13(11-21-12)14-8-15(19)10-16(9-14)25-23-18(22-24-25)17-4-2-3-7-20-17/h2-11H,1H3
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n/an/a 57n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154989
PNG
(2-[2-(5-Fluoro-biphenyl-3-yl)-2H-tetrazol-5-yl]-py...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C18H12FN5/c19-15-10-14(13-6-2-1-3-7-13)11-16(12-15)24-22-18(21-23-24)17-8-4-5-9-20-17/h1-12H
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n/an/a 247n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154984
PNG
(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1ncccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-16(5-4-8-20-12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)17-6-2-3-7-21-17/h2-11H,1H3
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n/an/a 41n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154986
PNG
(4-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Show SMILES Cc1cnccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C18H13FN6/c1-12-11-20-7-5-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3
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n/an/a 63n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154985
PNG
(3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C19H11FN6/c20-16-9-15(14-5-3-4-13(8-14)12-21)10-17(11-16)26-24-19(23-25-26)18-6-1-2-7-22-18/h1-11H
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n/an/a 253n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154981
PNG
(2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154981
PNG
(2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H
PDB
MMDB

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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5


Bioorg Med Chem Lett 15: 5061-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.062
BindingDB Entry DOI: 10.7270/Q2GT5MQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration towards human glutamate receptor 5 in calcium flux assay


J Med Chem 47: 4645-8 (2004)


Article DOI: 10.1021/jm049828c
BindingDB Entry DOI: 10.7270/Q2DJ5F3G
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50151910
PNG
(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N
Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H
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n/an/a 3.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5473-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.012
BindingDB Entry DOI: 10.7270/Q2F47NMM
More data for this
Ligand-Target Pair