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1 similar compounds to monomer 20464

Compile data set for download or QSAR
Wt: 428.4
BDBM50158658

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50158658   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50158658
PNG
((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2ccc3cccnc3c2)c(n1)N1CCOCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-4-16(21(28-19)29-10-12-31-13-11-29)5-8-20(30)27-17-6-3-15-2-1-9-26-18(15)14-17/h1-9,14H,10-13H2,(H,27,30)/b8-5+
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Article
PubMed
1.20n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assay


J Med Chem 55: 8392-408 (2012)


Article DOI: 10.1021/jm300780p
BindingDB Entry DOI: 10.7270/Q2TX3GH1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50158658
PNG
((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2ccc3cccnc3c2)c(n1)N1CCOCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-4-16(21(28-19)29-10-12-31-13-11-29)5-8-20(30)27-17-6-3-15-2-1-9-26-18(15)14-17/h1-9,14H,10-13H2,(H,27,30)/b8-5+
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Article
PubMed
n/an/a 116n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of pH-induced activity by FLIPR assay


J Med Chem 55: 8392-408 (2012)


Article DOI: 10.1021/jm300780p
BindingDB Entry DOI: 10.7270/Q2TX3GH1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50158658
PNG
((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2ccc3cccnc3c2)c(n1)N1CCOCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-4-16(21(28-19)29-10-12-31-13-11-29)5-8-20(30)27-17-6-3-15-2-1-9-26-18(15)14-17/h1-9,14H,10-13H2,(H,27,30)/b8-5+
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Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells


J Med Chem 48: 71-90 (2005)


Article DOI: 10.1021/jm049485i
BindingDB Entry DOI: 10.7270/Q2J67GDG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50158658
PNG
((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)Nc2ccc3cccnc3c2)c(n1)N1CCOCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-4-16(21(28-19)29-10-12-31-13-11-29)5-8-20(30)27-17-6-3-15-2-1-9-26-18(15)14-17/h1-9,14H,10-13H2,(H,27,30)/b8-5+
PDB
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Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells


J Med Chem 48: 71-90 (2005)


Article DOI: 10.1021/jm049485i
BindingDB Entry DOI: 10.7270/Q2J67GDG
More data for this
Ligand-Target Pair