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1 similar compounds to monomer 50160886

Wt: 459.4
BDBM50160887

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50160887   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Aurora


(Homo sapiens (human))
BDBM50160887
PNG
(CHEMBL3792988)
Show SMILES COC(=O)c1cccc(NC(=O)c2cc(ccc2O)-n2cc(CCNc3ncccn3)nn2)c1
Show InChI InChI=1S/C23H21N7O4/c1-34-22(33)15-4-2-5-16(12-15)27-21(32)19-13-18(6-7-20(19)31)30-14-17(28-29-30)8-11-26-23-24-9-3-10-25-23/h2-7,9-10,12-14,31H,8,11H2,1H3,(H,27,32)(H,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 7.67E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human Aurora A using H-LRRASLG as substrate after 2 hrs by HotSpot assay in presence of 33P-ATP and 10 uM ATP


Bioorg Med Chem 24: 2114-24 (2016)

More data for this
Ligand-Target Pair
Aurora kinase B/Inner centromere protein


(Homo sapiens (Human))
BDBM50160887
PNG
(CHEMBL3792988)
Show SMILES COC(=O)c1cccc(NC(=O)c2cc(ccc2O)-n2cc(CCNc3ncccn3)nn2)c1
Show InChI InChI=1S/C23H21N7O4/c1-34-22(33)15-4-2-5-16(12-15)27-21(32)19-13-18(6-7-20(19)31)30-14-17(28-29-30)8-11-26-23-24-9-3-10-25-23/h2-7,9-10,12-14,31H,8,11H2,1H3,(H,27,32)(H,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.52E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human Aurora B using H-LRRASLG as substrate after 2 hrs by HotSpot assay in presence of 33P-ATP and 10 uM ATP


Bioorg Med Chem 24: 2114-24 (2016)

More data for this
Ligand-Target Pair