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6 similar compounds to monomer 50162557

Compile data set for download or QSAR
Wt: 417.2
BDBM50162566
Wt: 443.3
BDBM50162568
Wt: 457.3
BDBM50162569
Wt: 474.3
BDBM50162571
Wt: 417.2
BDBM50162573
Wt: 499.4
BDBM50162576

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50162566,50162568,50162569,50162571,50162573,50162576   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162566
PNG
(6,7-Dichloro-2-propyl-5-[4-(2H-tetrazol-5-yl)-benz...)
Show SMILES CCCC1Cc2cc(OCc3ccc(cc3)-c3nnn[nH]3)c(Cl)c(Cl)c2C1=O
Show InChI InChI=1/C20H18Cl2N4O2/c1-2-3-13-8-14-9-15(17(21)18(22)16(14)19(13)27)28-10-11-4-6-12(7-5-11)20-23-25-26-24-20/h4-7,9,13H,2-3,8,10H2,1H3,(H,23,24,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 282n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162568
PNG
(6,7-Dichloro-2-cyclopentyl-5-[4-(2H-tetrazol-5-yl)...)
Show SMILES Clc1c2C(=O)C(Cc2cc(OCc2ccc(cc2)-c2nnn[nH]2)c1Cl)C1CCCC1
Show InChI InChI=1/C22H20Cl2N4O2/c23-19-17(30-11-12-5-7-14(8-6-12)22-25-27-28-26-22)10-15-9-16(13-3-1-2-4-13)21(29)18(15)20(19)24/h5-8,10,13,16H,1-4,9,11H2,(H,25,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 122n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162576
PNG
(2-Butyl-6,7-dichloro-2-cyclopentyl-5-[4-(2H-tetraz...)
Show SMILES CCCCC1(Cc2cc(OCc3ccc(cc3)-c3nnn[nH]3)c(Cl)c(Cl)c2C1=O)C1CCCC1
Show InChI InChI=1/C26H28Cl2N4O2/c1-2-3-12-26(19-6-4-5-7-19)14-18-13-20(22(27)23(28)21(18)24(26)33)34-15-16-8-10-17(11-9-16)25-29-31-32-30-25/h8-11,13,19H,2-7,12,14-15H2,1H3,(H,29,30,31,32)
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 1.09E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162573
PNG
(6,7-Dichloro-2-isopropyl-5-[4-(2H-tetrazol-5-yl)-b...)
Show SMILES CC(C)C1Cc2cc(OCc3ccc(cc3)-c3nnn[nH]3)c(Cl)c(Cl)c2C1=O
Show InChI InChI=1/C20H18Cl2N4O2/c1-10(2)14-7-13-8-15(17(21)18(22)16(13)19(14)27)28-9-11-3-5-12(6-4-11)20-23-25-26-24-20/h3-6,8,10,14H,7,9H2,1-2H3,(H,23,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 195n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162571
PNG
(CHEMBL180455 | N-Acetyl-4-(6,7-dichloro-2-cyclopen...)
Show SMILES CC(=O)NC(=O)c1ccc(COc2cc3CC(C)(C4CCCC4)C(=O)c3c(Cl)c2Cl)cc1
Show InChI InChI=1/C25H25Cl2NO4/c1-14(29)28-24(31)16-9-7-15(8-10-16)13-32-19-11-17-12-25(2,18-5-3-4-6-18)23(30)20(17)22(27)21(19)26/h7-11,18H,3-6,12-13H2,1-2H3,(H,28,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 442n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162569
PNG
(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[4-(2H-tetra...)
Show SMILES CC1(Cc2cc(OCc3ccc(cc3)-c3nnn[nH]3)c(Cl)c(Cl)c2C1=O)C1CCCC1
Show InChI InChI=1/C23H22Cl2N4O2/c1-23(16-4-2-3-5-16)11-15-10-17(19(24)20(25)18(15)21(23)30)31-12-13-6-8-14(9-7-13)22-26-28-29-27-22/h6-10,16H,2-5,11-12H2,1H3,(H,26,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 223n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair