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8 similar compounds to monomer 50166030

Compile data set for download or QSAR
Wt: 443.5
BDBM50162861
Wt: 443.5
BDBM50162862
Wt: 443.5
BDBM50162871
Wt: 443.5
BDBM50166023
Wt: 443.5
BDBM50166024
Wt: 443.5
BDBM50166025
Wt: 443.5
BDBM50166027
Wt: 443.5
BDBM50166028

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50162861,50162862,50162871,50166023,50166024,50166025,50166027,50166028   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50162862
PNG
(CHEMBL359654 | Naphthalene-2-carboxylic acid [4-(7...)
Show SMILES COc1cccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)CC3CCc12
Show InChI InChI=1S/C28H33N3O2/c1-33-27-10-6-9-26-25(27)14-13-24-20-30(17-18-31(24)26)16-5-4-15-29-28(32)23-12-11-21-7-2-3-8-22(21)19-23/h2-3,6-12,19,24H,4-5,13-18,20H2,1H3,(H,29,32)
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5.80n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity D3 [3H]-PD 128907 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats


Bioorg Med Chem Lett 15: 1701-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.037
BindingDB Entry DOI: 10.7270/Q2862FXD
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50166028
PNG
(CHEMBL434532 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1cccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc12
Show InChI InChI=1S/C28H33N3O2/c1-33-27-10-6-9-26-25(27)14-13-24-20-30(17-18-31(24)26)16-5-4-15-29-28(32)23-12-11-21-7-2-3-8-22(21)19-23/h2-3,6-12,19,24H,4-5,13-18,20H2,1H3,(H,29,32)/t24-/m1/s1
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8.30n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50166027
PNG
(CHEMBL363406 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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44n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50162861
PNG
(CHEMBL179781 | Naphthalene-2-carboxylic acid [4-(9...)
Show SMILES COc1ccc2CCC3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)
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45n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity D3 [3H]-PD 128907 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats


Bioorg Med Chem Lett 15: 1701-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.037
BindingDB Entry DOI: 10.7270/Q2862FXD
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50166024
PNG
(CHEMBL192138 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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67n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50166023
PNG
(CHEMBL192439 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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96n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50166025
PNG
(CHEMBL193040 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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126n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50162871
PNG
(CHEMBL361756 | Naphthalene-2-carboxylic acid [4-(8...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)CC3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)
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244n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity D3 [3H]-PD 128907 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats


Bioorg Med Chem Lett 15: 1701-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.037
BindingDB Entry DOI: 10.7270/Q2862FXD
More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50166028
PNG
(CHEMBL434532 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1cccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc12
Show InChI InChI=1S/C28H33N3O2/c1-33-27-10-6-9-26-25(27)14-13-24-20-30(17-18-31(24)26)16-5-4-15-29-28(32)23-12-11-21-7-2-3-8-22(21)19-23/h2-3,6-12,19,24H,4-5,13-18,20H2,1H3,(H,29,32)/t24-/m1/s1
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644n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50166023
PNG
(CHEMBL192439 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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990n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50166027
PNG
(CHEMBL363406 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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1.72E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine D1B


(RAT)
BDBM50166028
PNG
(CHEMBL434532 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1cccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc12
Show InChI InChI=1S/C28H33N3O2/c1-33-27-10-6-9-26-25(27)14-13-24-20-30(17-18-31(24)26)16-5-4-15-29-28(32)23-12-11-21-7-2-3-8-22(21)19-23/h2-3,6-12,19,24H,4-5,13-18,20H2,1H3,(H,29,32)/t24-/m1/s1
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2.71E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine D1B


(RAT)
BDBM50166023
PNG
(CHEMBL192439 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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4.33E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine D1B


(RAT)
BDBM50166027
PNG
(CHEMBL363406 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2CC[C@@H]3CN(CCCCNC(=O)c4ccc5ccccc5c4)CCN3c2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-13-11-22-10-12-25-20-30(16-17-31(25)27(22)19-26)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-23(21)18-24/h2-3,6-9,11,13,18-19,25H,4-5,10,12,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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1.08E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50166025
PNG
(CHEMBL193040 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine D1B


(RAT)
BDBM50166025
PNG
(CHEMBL193040 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine D1B


(RAT)
BDBM50166024
PNG
(CHEMBL192138 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50166024
PNG
(CHEMBL192138 | Naphthalene-2-carboxylic acid [4-((...)
Show SMILES COc1ccc2N3CCN(CCCCNC(=O)c4ccc5ccccc5c4)C[C@H]3CCc2c1
Show InChI InChI=1S/C28H33N3O2/c1-33-26-12-13-27-23(19-26)10-11-25-20-30(16-17-31(25)27)15-5-4-14-29-28(32)24-9-8-21-6-2-3-7-22(21)18-24/h2-3,6-9,12-13,18-19,25H,4-5,10-11,14-17,20H2,1H3,(H,29,32)/t25-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane


J Med Chem 48: 3171-81 (2005)


Article DOI: 10.1021/jm049031l
BindingDB Entry DOI: 10.7270/Q2NZ874W
More data for this
Ligand-Target Pair