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7 similar compounds to monomer 50287274

Compile data set for download or QSAR
Wt: 239.1
BDBM50174524
Wt: 311.2
BDBM50265763
Wt: 239.1
BDBM50314793
Wt: 283.2
BDBM50314800
Wt: 297.1
BDBM50314801
Wt: 239.1
BDBM50314804
Purchase
Wt: 253.1
BDBM50314809

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50174524,50265763,50314793,50314800,50314801,50314804,50314809   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamine synthetase


(Escherichia coli (strain K12))
BDBM50174524
PNG
((S)-2-Amino-4-[(2-carboxy-ethyl)-hydroxy-phosphino...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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Article
PubMed
1.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity towards glutamine synthetase


J Med Chem 48: 6340-9 (2005)


Article DOI: 10.1021/jm050474e
BindingDB Entry DOI: 10.7270/Q29C6Z6R
More data for this
Ligand-Target Pair
Glutamine synthetase


(Escherichia coli (strain K12))
BDBM50174524
PNG
((S)-2-Amino-4-[(2-carboxy-ethyl)-hydroxy-phosphino...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
PDB
MMDB

KEGG

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B.MOAD
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PubMed
n/an/a 9.70E+5n/an/an/an/a7.4n/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamine synthetase incubated at 37 degree C for 20 minutes in pH 7.4


J Med Chem 48: 6340-9 (2005)


Article DOI: 10.1021/jm050474e
BindingDB Entry DOI: 10.7270/Q29C6Z6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 5.20E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence micro...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 6.60E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314800
PNG
((3S)-3-[((3-Amino-3-carboxylate)propyl)(hydroxy)ph...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CCO)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H18NO7P/c10-7(9(14)15)2-4-18(16,17)5-6(1-3-11)8(12)13/h6-7,11H,1-5,10H2,(H,12,13)(H,14,15)(H,16,17)/t6?,7-/m0/s1
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PubMed
n/an/an/an/a 7.60E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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PubMed
n/an/an/an/a 3.50E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314804
PNG
((R)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m1/s1
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PubMed
n/an/an/an/a 5.80E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 2.00E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 7.80E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314809
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES CC(CP(O)(=O)CC[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H16NO6P/c1-5(7(10)11)4-16(14,15)3-2-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t5?,6-/m0/s1
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PubMed
n/an/an/an/a 5.30E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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PubMed
n/an/an/an/a 3.80E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 6.15E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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PubMed
n/an/an/an/a 8.90E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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PubMed
n/an/an/an/a 2.40E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314804
PNG
((R)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m1/s1
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PubMed
n/an/an/an/a 1.70E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 7.10E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 6.40E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314809
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES CC(CP(O)(=O)CC[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H16NO6P/c1-5(7(10)11)4-16(14,15)3-2-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t5?,6-/m0/s1
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n/an/an/an/a 1.21E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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n/an/an/an/a 4.60E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 6.70E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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n/an/an/an/a 4.20E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314804
PNG
((R)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m1/s1
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n/an/an/an/a 9.90E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 3.20E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 3.10E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314801
PNG
((3S)-2-[(((3-Amino-3-carboxy)propyl)(hydroxy)phosp...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16NO8P/c10-6(9(15)16)1-2-19(17,18)4-5(8(13)14)3-7(11)12/h5-6H,1-4,10H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t5?,6-/m0/s1
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n/an/an/an/a 1.15E+5n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Homo sapiens (Human))
BDBM50265763
PNG
(2-((((S)-3-amino-3-carboxypropyl)(hydroxy)phosphor...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H18NO8P/c11-7(10(16)17)3-4-20(18,19)5-6(9(14)15)1-2-8(12)13/h6-7H,1-5,11H2,(H,12,13)(H,14,15)(H,16,17)(H,18,19)/t6?,7-/m0/s1
PDB
MMDB

KEGG

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n/an/an/a 10.5n/an/an/an/an/a



Justus-Liebig-Universitat Giessen

Curated by ChEMBL


Assay Description
Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline buffer


J Med Chem 52: 544-50 (2009)


Article DOI: 10.1021/jm801033c
BindingDB Entry DOI: 10.7270/Q2MW2H04
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50314800
PNG
((3S)-3-[((3-Amino-3-carboxylate)propyl)(hydroxy)ph...)
Show SMILES N[C@@H](CCP(O)(=O)CC(CCO)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H18NO7P/c10-7(9(14)15)2-4-18(16,17)5-6(1-3-11)8(12)13/h6-7,11H,1-5,10H2,(H,12,13)(H,14,15)(H,16,17)/t6?,7-/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair