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4 similar compounds to monomer 50177592

Compile data set for download or QSAR
Wt: 415.8
BDBM50177594
Wt: 449.4
BDBM50177598
Wt: 415.8
BDBM50177599
Wt: 429.9
BDBM50177600

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50177594,50177598,50177599,50177600   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM50177594
PNG
(CHEMBL381763 | [2-chloro-4-(5-methyl-pyrazol-1-yl)...)
Show SMILES Cc1ccnn1-c1ccc(C(=O)N2Cc3cccnc3Nc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C23H18ClN5O/c1-15-10-12-26-29(15)17-8-9-18(19(24)13-17)23(30)28-14-16-5-4-11-25-22(16)27-20-6-2-3-7-21(20)28/h2-13H,14H2,1H3,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]AVP from human V2 receptor transfected in LV2 cells


Bioorg Med Chem Lett 16: 954-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.107
BindingDB Entry DOI: 10.7270/Q27945GR
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM50177600
PNG
(CHEMBL205013 | [2-chloro-4-(3-methyl-pyrazol-1-yl)...)
Show SMILES CN1c2ccccc2N(Cc2cccnc12)C(=O)c1ccc(cc1Cl)-n1ccc(C)n1
Show InChI InChI=1S/C24H20ClN5O/c1-16-11-13-30(27-16)18-9-10-19(20(25)14-18)24(31)29-15-17-6-5-12-26-23(17)28(2)21-7-3-4-8-22(21)29/h3-14H,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 475n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]AVP from human V2 receptor transfected in LV2 cells


Bioorg Med Chem Lett 16: 954-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.107
BindingDB Entry DOI: 10.7270/Q27945GR
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM50177599
PNG
(CHEMBL202447 | [2-chloro-4-(3-methyl-pyrazol-1-yl)...)
Show SMILES Cc1ccn(n1)-c1ccc(C(=O)N2Cc3cccnc3Nc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C23H18ClN5O/c1-15-10-12-29(27-15)17-8-9-18(19(24)13-17)23(30)28-14-16-5-4-11-25-22(16)26-20-6-2-3-7-21(20)28/h2-13H,14H2,1H3,(H,25,26)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 91.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]AVP from human V2 receptor transfected in LV2 cells


Bioorg Med Chem Lett 16: 954-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.107
BindingDB Entry DOI: 10.7270/Q27945GR
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM50177598
PNG
((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Show SMILES Cc1ccnn1-c1ccc(C(=O)N2Cc3cccnc3Nc3ccccc23)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-10-12-29-32(15)17-8-9-18(19(13-17)24(25,26)27)23(33)31-14-16-5-4-11-28-22(16)30-20-6-2-3-7-21(20)31/h2-13H,14H2,1H3,(H,28,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 413n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]AVP from human V2 receptor transfected in LV2 cells


Bioorg Med Chem Lett 16: 954-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.107
BindingDB Entry DOI: 10.7270/Q27945GR
More data for this
Ligand-Target Pair