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3 similar compounds to monomer 50180146

Compile data set for download or QSAR
Wt: 199.2
BDBM50180145
Wt: 215.2
BDBM50240399
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Wt: 171.1
BDBM50327886
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50180145,50240399,50327886   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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376n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR7


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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376n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat cloned iGluR7


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50327886
PNG
((1R,2S,5S,6S)-3-azabicyclo[3.1.0]hexane-2,6-dicarb...)
Show SMILES OC(=O)[C@H]1[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1/C7H9NO4/c9-6(10)4-2-1-8-5(3(2)4)7(11)12/h2-5,8H,1H2,(H,9,10)(H,11,12)/t2-,3+,4-,5-/s2
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1.60E+3n/an/an/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)


Article DOI: 10.1021/jm100959g
BindingDB Entry DOI: 10.7270/Q27081NR
More data for this
Ligand-Target Pair
GRIK4


(Homo sapiens (Human))
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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3.84E+3n/an/an/an/an/an/an/an/a



Allelix Biopharmaceuticals, Inc.

Curated by PDSP Ki Database




J Neurochem 62: 1-9 (1994)


Article DOI: 10.1016/j.bioorg.2015.05.009
BindingDB Entry DOI: 10.7270/Q2RJ4H0P
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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6.00E+3n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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8.18E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR5


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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8.18E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat cloned iGluR5


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50327886
PNG
((1R,2S,5S,6S)-3-azabicyclo[3.1.0]hexane-2,6-dicarb...)
Show SMILES OC(=O)[C@H]1[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1/C7H9NO4/c9-6(10)4-2-1-8-5(3(2)4)7(11)12/h2-5,8H,1H2,(H,9,10)(H,11,12)/t2-,3+,4-,5-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




J Pharmacol Exp Ther 298: 453-60 (2001)


Article DOI: 10.1016/j.bioorg.2016.02.004
BindingDB Entry DOI: 10.7270/Q2V986M2
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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1.23E+4n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat cloned iGluR6


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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1.23E+4n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR6


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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4.60E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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5.20E+4n/an/an/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)


Article DOI: 10.1021/jm100959g
BindingDB Entry DOI: 10.7270/Q27081NR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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5.20E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT2 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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1.27E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT1 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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n/an/an/an/a 1.00E+6n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against mGluR2


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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n/an/a>3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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n/an/a>3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against mGluR1


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50240399
PNG
((2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidin...)
Show SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
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UniChem

Patents


Similars

Article
PubMed
n/an/a 8.90E+4n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair