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35 similar compounds to monomer 50183841

Compile data set for download or QSAR
Wt: 445.8
BDBM50183831
Wt: 386.8
BDBM50183832
Wt: 443.9
BDBM50183833
Wt: 403.8
BDBM50183834
Wt: 417.8
BDBM50183835
Wt: 415.8
BDBM50183836
Wt: 429.8
BDBM50183837
Wt: 461.9
BDBM50183838
Wt: 458.9
BDBM50183839
Wt: 486.9
BDBM50183840
Wt: 429.8
BDBM50183842
Wt: 447.8
BDBM50183843
Wt: 433.8
BDBM50183844
Wt: 443.9
BDBM50183845
Wt: 515.0
BDBM50183846
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 195 hits for monomerid = 50183831,50183832,50183833,50183834,50183835,50183836,50183837,50183838,50183839,50183840,50183842,50183843,50183844,50183845,50183846   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183840
PNG
(3-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CN(C1)C(C)C)C(N)=O
Show InChI InChI=1S/C24H28ClFN6O2/c1-14(2)32-11-24(12-32,23(27)33)31(3)10-15-8-16-19(9-20(15)34-4)28-13-29-22(16)30-18-7-5-6-17(25)21(18)26/h5-9,13-14H,10-12H2,1-4H3,(H2,27,33)(H,28,29,30)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183838
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COCCN(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@@H](C)C(N)=O
Show InChI InChI=1S/C22H25ClFN5O3/c1-13(21(25)30)29(7-8-31-2)11-14-9-15-18(10-19(14)32-3)26-12-27-22(15)28-17-6-4-5-16(23)20(17)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H2,25,30)(H,26,27,28)/t13-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183843
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COC[C@H](N(C)Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)C(N)=O
Show InChI InChI=1S/C21H23ClFN5O3/c1-28(17(10-30-2)20(24)29)9-12-7-13-16(8-18(12)31-3)25-11-26-21(13)27-15-6-4-5-14(22)19(15)23/h4-8,11,17H,9-10H2,1-3H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183831
PNG
(4-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCOCC1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O3/c1-30-18-8-16-13(7-12(18)9-28-5-6-31-10-17(28)20(24)29)21(26-11-25-16)27-15-4-2-3-14(22)19(15)23/h2-4,7-8,11,17H,5-6,9-10H2,1H3,(H2,24,29)(H,25,26,27)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183840
PNG
(3-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CN(C1)C(C)C)C(N)=O
Show InChI InChI=1S/C24H28ClFN6O2/c1-14(2)32-11-24(12-32,23(27)33)31(3)10-15-8-16-19(9-20(15)34-4)28-13-29-22(16)30-18-7-5-6-17(25)21(18)26/h5-9,13-14H,10-12H2,1-4H3,(H2,27,33)(H,28,29,30)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183838
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COCCN(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@@H](C)C(N)=O
Show InChI InChI=1S/C22H25ClFN5O3/c1-13(21(25)30)29(7-8-31-2)11-14-9-15-18(10-19(14)32-3)26-12-27-22(15)28-17-6-4-5-16(23)20(17)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H2,25,30)(H,26,27,28)/t13-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183834
PNG
((R)-2-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN[C@H](C)C(N)=O
Show InChI InChI=1S/C19H19ClFN5O2/c1-10(18(22)27)23-8-11-6-12-15(7-16(11)28-2)24-9-25-19(12)26-14-5-3-4-13(20)17(14)21/h3-7,9-10,23H,8H2,1-2H3,(H2,22,27)(H,24,25,26)/t10-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183834
PNG
((R)-2-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN[C@H](C)C(N)=O
Show InChI InChI=1S/C19H19ClFN5O2/c1-10(18(22)27)23-8-11-6-12-15(7-16(11)28-2)24-9-25-19(12)26-14-5-3-4-13(20)17(14)21/h3-7,9-10,23H,8H2,1-2H3,(H2,22,27)(H,24,25,26)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183834
PNG
((R)-2-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN[C@H](C)C(N)=O
Show InChI InChI=1S/C19H19ClFN5O2/c1-10(18(22)27)23-8-11-6-12-15(7-16(11)28-2)24-9-25-19(12)26-14-5-3-4-13(20)17(14)21/h3-7,9-10,23H,8H2,1-2H3,(H2,22,27)(H,24,25,26)/t10-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183845
PNG
((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES CNC(=O)[C@H]1CCCN1Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Show InChI InChI=1S/C22H23ClFN5O2/c1-25-22(30)18-7-4-8-29(18)11-13-9-14-17(10-19(13)31-2)26-12-27-21(14)28-16-6-3-5-15(23)20(16)24/h3,5-6,9-10,12,18H,4,7-8,11H2,1-2H3,(H,25,30)(H,26,27,28)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183845
PNG
((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES CNC(=O)[C@H]1CCCN1Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Show InChI InChI=1S/C22H23ClFN5O2/c1-25-22(30)18-7-4-8-29(18)11-13-9-14-17(10-19(13)31-2)26-12-27-21(14)28-16-6-3-5-15(23)20(16)24/h3,5-6,9-10,12,18H,4,7-8,11H2,1-2H3,(H,25,30)(H,26,27,28)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183844
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@@H](CO)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O3/c1-27(16(9-28)19(23)29)8-11-6-12-15(7-17(11)30-2)24-10-25-20(12)26-14-5-3-4-13(21)18(14)22/h3-7,10,16,28H,8-9H2,1-2H3,(H2,23,29)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183845
PNG
((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES CNC(=O)[C@H]1CCCN1Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Show InChI InChI=1S/C22H23ClFN5O2/c1-25-22(30)18-7-4-8-29(18)11-13-9-14-17(10-19(13)31-2)26-12-27-21(14)28-16-6-3-5-15(23)20(16)24/h3,5-6,9-10,12,18H,4,7-8,11H2,1-2H3,(H,25,30)(H,26,27,28)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183844
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@@H](CO)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O3/c1-27(16(9-28)19(23)29)8-11-6-12-15(7-17(11)30-2)24-10-25-20(12)26-14-5-3-4-13(21)18(14)22/h3-7,10,16,28H,8-9H2,1-2H3,(H2,23,29)(H,24,25,26)/t16-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183844
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@@H](CO)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O3/c1-27(16(9-28)19(23)29)8-11-6-12-15(7-17(11)30-2)24-10-25-20(12)26-14-5-3-4-13(21)18(14)22/h3-7,10,16,28H,8-9H2,1-2H3,(H2,23,29)(H,24,25,26)/t16-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (Human))
BDBM50183846
PNG
(4-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CCN(CC1)C(C)C)C(N)=O
Show InChI InChI=1S/C26H32ClFN6O2/c1-16(2)34-10-8-26(9-11-34,25(29)35)33(3)14-17-12-18-21(13-22(17)36-4)30-15-31-24(18)32-20-7-5-6-19(27)23(20)28/h5-7,12-13,15-16H,8-11,14H2,1-4H3,(H2,29,35)(H,30,31,32)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of PKA


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183840
PNG
(3-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CN(C1)C(C)C)C(N)=O
Show InChI InChI=1S/C24H28ClFN6O2/c1-14(2)32-11-24(12-32,23(27)33)31(3)10-15-8-16-19(9-20(15)34-4)28-13-29-22(16)30-18-7-5-6-17(25)21(18)26/h5-9,13-14H,10-12H2,1-4H3,(H2,27,33)(H,28,29,30)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183831
PNG
(4-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCOCC1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O3/c1-30-18-8-16-13(7-12(18)9-28-5-6-31-10-17(28)20(24)29)21(26-11-25-16)27-15-4-2-3-14(22)19(15)23/h2-4,7-8,11,17H,5-6,9-10H2,1H3,(H2,24,29)(H,25,26,27)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183843
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COC[C@H](N(C)Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)C(N)=O
Show InChI InChI=1S/C21H23ClFN5O3/c1-28(17(10-30-2)20(24)29)9-12-7-13-16(8-18(12)31-3)25-11-26-21(13)27-15-6-4-5-14(22)19(15)23/h4-8,11,17H,9-10H2,1-3H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183838
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COCCN(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@@H](C)C(N)=O
Show InChI InChI=1S/C22H25ClFN5O3/c1-13(21(25)30)29(7-8-31-2)11-14-9-15-18(10-19(14)32-3)26-12-27-22(15)28-17-6-4-5-16(23)20(17)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H2,25,30)(H,26,27,28)/t13-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (Human))
BDBM50183839
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCN(C)CC1C(N)=O
Show InChI InChI=1S/C22H24ClFN6O2/c1-29-6-7-30(18(11-29)21(25)31)10-13-8-14-17(9-19(13)32-2)26-12-27-22(14)28-16-5-3-4-15(23)20(16)24/h3-5,8-9,12,18H,6-7,10-11H2,1-2H3,(H2,25,31)(H,26,27,28)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of PKA


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (Human))
BDBM50183833
PNG
((S)-2-(1-((4-(3-chloro-2-fluorophenylamino)-7-meth...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1CC(N)=O
Show InChI InChI=1S/C22H23ClFN5O2/c1-31-19-10-18-15(8-13(19)11-29-7-3-4-14(29)9-20(25)30)22(27-12-26-18)28-17-6-2-5-16(23)21(17)24/h2,5-6,8,10,12,14H,3-4,7,9,11H2,1H3,(H2,25,30)(H,26,27,28)/t14-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of PKA


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183842
PNG
((S)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-18-9-16-13(8-12(18)10-28-7-3-6-17(28)20(24)29)21(26-11-25-16)27-15-5-2-4-14(22)19(15)23/h2,4-5,8-9,11,17H,3,6-7,10H2,1H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183839
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCN(C)CC1C(N)=O
Show InChI InChI=1S/C22H24ClFN6O2/c1-29-6-7-30(18(11-29)21(25)31)10-13-8-14-17(9-19(13)32-2)26-12-27-22(14)28-16-5-3-4-15(23)20(16)24/h3-5,8-9,12,18H,6-7,10-11H2,1-2H3,(H2,25,31)(H,26,27,28)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183836
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CC(C1)C(N)=O
Show InChI InChI=1S/C20H19ClFN5O2/c1-29-17-6-16-13(5-11(17)7-27-8-12(9-27)19(23)28)20(25-10-24-16)26-15-4-2-3-14(21)18(15)22/h2-6,10,12H,7-9H2,1H3,(H2,23,28)(H,24,25,26)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183833
PNG
((S)-2-(1-((4-(3-chloro-2-fluorophenylamino)-7-meth...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1CC(N)=O
Show InChI InChI=1S/C22H23ClFN5O2/c1-31-19-10-18-15(8-13(19)11-29-7-3-4-14(29)9-20(25)30)22(27-12-26-18)28-17-6-2-5-16(23)21(17)24/h2,5-6,8,10,12,14H,3-4,7,9,11H2,1H3,(H2,25,30)(H,26,27,28)/t14-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183837
PNG
((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1CN1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-19-9-17-14(7-12(19)10-28-6-2-3-18(28)20(24)29)21(26-11-25-17)27-13-4-5-16(23)15(22)8-13/h4-5,7-9,11,18H,2-3,6,10H2,1H3,(H2,24,29)(H,25,26,27)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (Human))
BDBM50183832
PNG
(CHEMBL437885 | N-(3-chloro-2-fluorophenyl)-7-metho...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCCC1
Show InChI InChI=1S/C20H20ClFN4O/c1-27-18-10-17-14(9-13(18)11-26-7-2-3-8-26)20(24-12-23-17)25-16-6-4-5-15(21)19(16)22/h4-6,9-10,12H,2-3,7-8,11H2,1H3,(H,23,24,25)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of PKA


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50183833
PNG
((S)-2-(1-((4-(3-chloro-2-fluorophenylamino)-7-meth...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1CC(N)=O
Show InChI InChI=1S/C22H23ClFN5O2/c1-31-19-10-18-15(8-13(19)11-29-7-3-4-14(29)9-20(25)30)22(27-12-26-18)28-17-6-2-5-16(23)21(17)24/h2,5-6,8,10,12,14H,3-4,7,9,11H2,1H3,(H2,25,30)(H,26,27,28)/t14-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of SAP kinase


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183832
PNG
(CHEMBL437885 | N-(3-chloro-2-fluorophenyl)-7-metho...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCCC1
Show InChI InChI=1S/C20H20ClFN4O/c1-27-18-10-17-14(9-13(18)11-26-7-2-3-8-26)20(24-12-23-17)25-16-6-4-5-15(21)19(16)22/h4-6,9-10,12H,2-3,7-8,11H2,1H3,(H,23,24,25)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183837
PNG
((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1CN1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-19-9-17-14(7-12(19)10-28-6-2-3-18(28)20(24)29)21(26-11-25-17)27-13-4-5-16(23)15(22)8-13/h4-5,7-9,11,18H,2-3,6,10H2,1H3,(H2,24,29)(H,25,26,27)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50183839
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCN(C)CC1C(N)=O
Show InChI InChI=1S/C22H24ClFN6O2/c1-29-6-7-30(18(11-29)21(25)31)10-13-8-14-17(9-19(13)32-2)26-12-27-22(14)28-16-5-3-4-15(23)20(16)24/h3-5,8-9,12,18H,6-7,10-11H2,1-2H3,(H2,25,31)(H,26,27,28)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of SAP kinase


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183835
PNG
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O2/c1-11(19(23)28)27(2)9-12-7-13-16(8-17(12)29-3)24-10-25-20(13)26-15-6-4-5-14(21)18(15)22/h4-8,10-11H,9H2,1-3H3,(H2,23,28)(H,24,25,26)/t11-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183835
PNG
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O2/c1-11(19(23)28)27(2)9-12-7-13-16(8-17(12)29-3)24-10-25-20(13)26-15-6-4-5-14(21)18(15)22/h4-8,10-11H,9H2,1-3H3,(H2,23,28)(H,24,25,26)/t11-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183835
PNG
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O2/c1-11(19(23)28)27(2)9-12-7-13-16(8-17(12)29-3)24-10-25-20(13)26-15-6-4-5-14(21)18(15)22/h4-8,10-11H,9H2,1-3H3,(H2,23,28)(H,24,25,26)/t11-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50183846
PNG
(4-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CCN(CC1)C(C)C)C(N)=O
Show InChI InChI=1S/C26H32ClFN6O2/c1-16(2)34-10-8-26(9-11-34,25(29)35)33(3)14-17-12-18-21(13-22(17)36-4)30-15-31-24(18)32-20-7-5-6-19(27)23(20)28/h5-7,12-13,15-16H,8-11,14H2,1-4H3,(H2,29,35)(H,30,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of SAP kinase


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183837
PNG
((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1CN1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-19-9-17-14(7-12(19)10-28-6-2-3-18(28)20(24)29)21(26-11-25-17)27-13-4-5-16(23)15(22)8-13/h4-5,7-9,11,18H,2-3,6,10H2,1H3,(H2,24,29)(H,25,26,27)/t18-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183844
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@@H](CO)C(N)=O
Show InChI InChI=1S/C20H21ClFN5O3/c1-27(16(9-28)19(23)29)8-11-6-12-15(7-17(11)30-2)24-10-25-20(12)26-14-5-3-4-13(21)18(14)22/h3-7,10,16,28H,8-9H2,1-2H3,(H2,23,29)(H,24,25,26)/t16-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50183832
PNG
(CHEMBL437885 | N-(3-chloro-2-fluorophenyl)-7-metho...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCCC1
Show InChI InChI=1S/C20H20ClFN4O/c1-27-18-10-17-14(9-13(18)11-26-7-2-3-8-26)20(24-12-23-17)25-16-6-4-5-15(21)19(16)22/h4-6,9-10,12H,2-3,7-8,11H2,1H3,(H,23,24,25)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183845
PNG
((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES CNC(=O)[C@H]1CCCN1Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Show InChI InChI=1S/C22H23ClFN5O2/c1-25-22(30)18-7-4-8-29(18)11-13-9-14-17(10-19(13)31-2)26-12-27-21(14)28-16-6-3-5-15(23)20(16)24/h3,5-6,9-10,12,18H,4,7-8,11H2,1-2H3,(H,25,30)(H,26,27,28)/t18-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183831
PNG
(4-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCOCC1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O3/c1-30-18-8-16-13(7-12(18)9-28-5-6-31-10-17(28)20(24)29)21(26-11-25-16)27-15-4-2-3-14(22)19(15)23/h2-4,7-8,11,17H,5-6,9-10H2,1H3,(H2,24,29)(H,25,26,27)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183843
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COC[C@H](N(C)Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)C(N)=O
Show InChI InChI=1S/C21H23ClFN5O3/c1-28(17(10-30-2)20(24)29)9-12-7-13-16(8-18(12)31-3)25-11-26-21(13)27-15-6-4-5-14(22)19(15)23/h4-8,11,17H,9-10H2,1-3H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183834
PNG
((R)-2-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN[C@H](C)C(N)=O
Show InChI InChI=1S/C19H19ClFN5O2/c1-10(18(22)27)23-8-11-6-12-15(7-16(11)28-2)24-9-25-19(12)26-14-5-3-4-13(20)17(14)21/h3-7,9-10,23H,8H2,1-2H3,(H2,22,27)(H,24,25,26)/t10-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183836
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CC(C1)C(N)=O
Show InChI InChI=1S/C20H19ClFN5O2/c1-29-17-6-16-13(5-11(17)7-27-8-12(9-27)19(23)28)20(25-10-24-16)26-15-4-2-3-14(21)18(15)22/h2-6,10,12H,7-9H2,1H3,(H2,23,28)(H,24,25,26)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183838
PNG
((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Show SMILES COCCN(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@@H](C)C(N)=O
Show InChI InChI=1S/C22H25ClFN5O3/c1-13(21(25)30)29(7-8-31-2)11-14-9-15-18(10-19(14)32-3)26-12-27-22(15)28-17-6-4-5-16(23)20(17)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H2,25,30)(H,26,27,28)/t13-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183842
PNG
((S)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-18-9-16-13(8-12(18)10-28-7-3-6-17(28)20(24)29)21(26-11-25-16)27-15-5-2-4-14(22)19(15)23/h2,4-5,8-9,11,17H,3,6-7,10H2,1H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50183842
PNG
((S)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C21H21ClFN5O2/c1-30-18-9-16-13(8-12(18)10-28-7-3-6-17(28)20(24)29)21(26-11-25-16)27-15-5-2-4-14(22)19(15)23/h2,4-5,8-9,11,17H,3,6-7,10H2,1H3,(H2,24,29)(H,25,26,27)/t17-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of ROCK2


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50183836
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CC(C1)C(N)=O
Show InChI InChI=1S/C20H19ClFN5O2/c1-29-17-6-16-13(5-11(17)7-27-8-12(9-27)19(23)28)20(25-10-24-16)26-15-4-2-3-14(21)18(15)22/h2-6,10,12H,7-9H2,1H3,(H2,23,28)(H,24,25,26)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of JNK


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50183840
PNG
(3-(((4-(3-chloro-2-fluorophenylamino)-7-methoxyqui...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(CN(C1)C(C)C)C(N)=O
Show InChI InChI=1S/C24H28ClFN6O2/c1-14(2)32-11-24(12-32,23(27)33)31(3)10-15-8-16-19(9-20(15)34-4)28-13-29-22(16)30-18-7-5-6-17(25)21(18)26/h5-9,13-14H,10-12H2,1-4H3,(H2,27,33)(H,28,29,30)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of SAP kinase


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50183836
PNG
(1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CC(C1)C(N)=O
Show InChI InChI=1S/C20H19ClFN5O2/c1-29-17-6-16-13(5-11(17)7-27-8-12(9-27)19(23)28)20(25-10-24-16)26-15-4-2-3-14(21)18(15)22/h2-6,10,12H,7-9H2,1H3,(H2,23,28)(H,24,25,26)
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 2 uM ATP


Bioorg Med Chem Lett 16: 2672-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.025
BindingDB Entry DOI: 10.7270/Q25H7FVK
More data for this
Ligand-Target Pair
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