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1 similar compounds to monomer 50185433

Compile data set for download or QSAR
Wt: 419.5
BDBM50185434

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50185434   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maternal embryonic leucine zipper kinase


(Homo sapiens (Human))
BDBM50185434
PNG
(CHEMBL3823302)
Show SMILES C(Oc1cnccc1-c1cnn(c1)-c1ccc(cc1)N1CCOCC1)C1CCNCC1
Show InChI InChI=1S/C24H29N5O2/c1-3-22(4-2-21(1)28-11-13-30-14-12-28)29-17-20(15-27-29)23-7-10-26-16-24(23)31-18-19-5-8-25-9-6-19/h1-4,7,10,15-17,19,25H,5-6,8-9,11-14,18H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...


J Med Chem 59: 4711-23 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00052
BindingDB Entry DOI: 10.7270/Q2MK6FTG
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase


(Homo sapiens (Human))
BDBM50185434
PNG
(CHEMBL3823302)
Show SMILES C(Oc1cnccc1-c1cnn(c1)-c1ccc(cc1)N1CCOCC1)C1CCNCC1
Show InChI InChI=1S/C24H29N5O2/c1-3-22(4-2-21(1)28-11-13-30-14-12-28)29-17-20(15-27-29)23-7-10-26-16-24(23)31-18-19-5-8-25-9-6-19/h1-4,7,10,15-17,19,25H,5-6,8-9,11-14,18H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...


J Med Chem 59: 4711-23 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00052
BindingDB Entry DOI: 10.7270/Q2MK6FTG
More data for this
Ligand-Target Pair